Potent Activity of Indolequinones against Human Pancreatic Cancer: Identification of Thioredoxin Reductase as a Potential Target
Yan, Chao, Shieh, Biehuoy, Reigan, Philip, Zhang, Zhiyong, Colucci, Marie A, Chilloux, Aurélie, Newsome, Jeffery J, Siegel, David, Chan, Dan, Moody, Christopher J, Ross, David
Published in Molecular pharmacology (01.07.2009)
Published in Molecular pharmacology (01.07.2009)
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Journal Article
Synthesis and Evaluation of 3-Aryloxymethyl-1,2-dimethylindole-4,7-diones as Mechanism-Based Inhibitors of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Activity
Colucci, Marie A, Reigan, Philip, Siegel, David, Chilloux, Aurélie, Ross, David, Moody, Christopher J
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
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Journal Article
Mechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition
Dufour, Marine, Yan, Chao, Siegel, David, Colucci, Marie A., Jenner, Matthew, Oldham, Neil J., Gomez, Joe, Reigan, Philip, Li, Yazhuo, De Matteis, Cristina I., Ross, David, Moody, Christopher J.
Published in Chembiochem : a European journal of chemical biology (16.05.2011)
Published in Chembiochem : a European journal of chemical biology (16.05.2011)
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Journal Article
Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential
Colucci, Marie A, Moody, Christopher J, Couch, Gavin D
Published in Organic & biomolecular chemistry (01.01.2008)
Published in Organic & biomolecular chemistry (01.01.2008)
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Journal Article
Development of Indolequinone Mechanism-Based Inhibitors of NAD(P)H:Quinone Oxidoreductase 1 (NQO1): NQO1 Inhibition and Growth Inhibitory Activity in Human Pancreatic MIA PaCa-2 Cancer Cells
Reigan, Philip, Colucci, Marie A, Siegel, David, Chilloux, Aurélie, Moody, Christopher J, Ross, David
Published in Biochemistry (Easton) (22.05.2007)
Published in Biochemistry (Easton) (22.05.2007)
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Synthesis of potential prodrug systems for reductive activation. Prodrugs for anti-angiogenic isoflavones and VEGF receptor tyrosine kinase inhibitory oxindoles
Blanche, Emilie A., Maskell, Lesley, Colucci, Marie A., Whatmore, Jacqueline L., Moody, Christopher J.
Published in Tetrahedron (20.06.2009)
Published in Tetrahedron (20.06.2009)
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New functionalised silicas for highly selective cation exchange SPE purification in medicinal chemistry
Brown, Jane, Chighine, Alessandra, Colucci, Marie A., Galaffu, Nicola, Hirst, Simon C., Seymour, Helen M., Shiers, Jason J., Wilkes, Robin D., Williams, Jonathan G., Wilson, John R.H.
Published in Tetrahedron letters (11.08.2008)
Published in Tetrahedron letters (11.08.2008)
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The use of hexamethyldisilathiane for the synthesis of transition metal sulfides
Carmalt, Claire J., Dinnage, Christopher W., Parkin, Ivan P., Peters, Emily S., Molloy, Kieran, Colucci, Marie A.
Published in Polyhedron (01.05.2003)
Published in Polyhedron (01.05.2003)
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Journal Article
Indole derivatives and methods of using the same
Dehn, Donna, Siegel, David, Ross, David, Colucci, Marie A, Reigan, Philip, Moody, Christopher J
Year of Publication 26.02.2019
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Year of Publication 26.02.2019
Patent
INDOLE DERIVATIVES AND METHODS OF USING THE SAME
DEHN DONNA, SIEGEL DAVID, REIGAN PHILIP, MOODY CHRISTOPHER J, COLUCCI MARIE A, ROSS DAVID
Year of Publication 10.09.2009
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Year of Publication 10.09.2009
Patent
INDOLE DERIVATIVES AND METHODS OF USING THE SAME
MOODY, CHRISTOPHER, J, DEHN, DONNA, COLUCCI, MARIE, A, ROSS, DAVID, REIGAN, PHILIP, SIEGEL, DAVID
Year of Publication 15.07.2009
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Year of Publication 15.07.2009
Patent
INDOLE DERIVATIVES AND METHODS OF USING THE SAME
MOODY, CHRISTOPHER, J, DEHN, DONNA, COLUCCI, MARIE, A, ROSS, DAVID, REIGAN, PHILIP, SIEGEL, DAVID
Year of Publication 12.12.2007
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Year of Publication 12.12.2007
Patent
INDOLE DERIVATIVES AND METHODS OF USING THE SAME
MOODY, CHRISTOPHER, J, DEHN, DONNA, COLUCCI, MARIE, A, ROSS, DAVID, REIGAN, PHILIP, SIEGEL, DAVID
Year of Publication 21.09.2006
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Year of Publication 21.09.2006
Patent