Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm
Chelliah, Vijayalakshmi, Lazarou, Georgia, Bhatnagar, Sumit, Gibbs, John P., Nijsen, Marjoleen, Ray, Avijit, Stoll, Brian, Thompson, R. Adam, Gulati, Abhishek, Soukharev, Serguei, Yamada, Akihiro, Weddell, Jared, Sayama, Hiroyuki, Oishi, Masayo, Wittemer‐Rump, Sabine, Patel, Chirag, Niederalt, Christoph, Burghaus, Rolf, Scheerans, Christian, Lippert, Jörg, Kabilan, Senthil, Kareva, Irina, Belousova, Natalya, Rolfe, Alex, Zutshi, Anup, Chenel, Marylore, Venezia, Filippo, Fouliard, Sylvain, Oberwittler, Heike, Scholer‐Dahirel, Alix, Lelievre, Helene, Bottino, Dean, Collins, Sabrina C., Nguyen, Hoa Q., Wang, Haiqing, Yoneyama, Tomoki, Zhu, Andy Z.X., Graaf, Piet H., Kierzek, Andrzej M.
Published in Clinical pharmacology and therapeutics (01.03.2021)
Published in Clinical pharmacology and therapeutics (01.03.2021)
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Journal Article
Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor
Coser, Kathryn R, Wittner, Ben S, Rosenthal, Noël F, Collins, Sabrina C, Melas, Antonia, Smith, Shannon L, Mahoney, Crystal J, Shioda, Keiko, Isselbacher, Kurt J, Ramaswamy, Sridhar, Shioda, Toshi
Published in Proceedings of the National Academy of Sciences - PNAS (25.08.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (25.08.2009)
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Journal Article
357 TAK-573, an anti-CD38–attenuated interferon alpha (IFNα) fusion protein (Attenukine™), has demonstrated IFNα receptor (IFNAR) pathway modulation in patients with relapsed/refractory multiple myeloma
Collins, Sabrina, Joshi, Adarsh, Shen, Lei, Das, Subhasree, Suryanarayan, Kaveri, Bottino, Dean, Li, Cheryl, Curley, Michael, Wang, Dannie, Abadier, Michael, Larson, Ryan, Parot, Xavier
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
1068 Evaluation of the innate and adaptive immune modulatory properties and anti-tumor activity of CD38-targeted interferon alpha
Sampson, James F, Zhang, Hong, Hara, Tomoya, Zhang, Dong Mei, Hinthorne, Adam J, Collins, Sabrina C, Curley, Michael D
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Modakafusp Alfa (TAK-573), a Novel CD38-Targeting Attenuated Interferon-Alpha Immunocytokine, Kills MM Cells Via NK Cell Activation
Bruins, Wassilis S.C., Rentenaar, Rosa, Collins, Sabrina, Sampson, James F., Van De Donk, Niels WCJ, Zweegman, Sonja, Mutis, Tuna
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Final Results from the First-in-Human Phase 1/2 Study of Modakafusp Alfa, an Immune-Targeting Attenuated Cytokine, in Patients (Pts) with Relapsed/Refractory Multiple Myeloma (RRMM)
Vogl, Dan T., Atrash, Shebli, Holstein, Sarah A., Nadeem, Omar, Benson, Don M., Suryanarayan, Kaveri, Liu, Yuyin, Collins, Sabrina, Parot, Xavier, Kaufman, Jonathan L.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Dose escalation of a phase 1b/2 study of modakafusp alfa, an immune-targeting attenuated cytokine, in patients (pts) with metastatic solid tumors
Johnson, Melissa Lynne, Abdul-Karim, Raghad, Sommerhalder, David, Hafez, Navid, Wang, Shining, Li, Cheryl, Liu, Yuyin, Yang, Lili, Collins, Sabrina, Parot, Xavier, Strauss, James F.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
Modakafusp Alfa Demonstrates Type I Interferon-Mediated Innate and Adaptive Immune Enhancement in a Phase 1/2 Study in Patients with Relapsed and/or Refractory Multiple Myeloma (RRMM)
Saggu, Gurpanna, Lee, Min Young, Dunbar, Faith, Singh, Reshma, Sachsenmeier, Kris, Vogl, Dan T., Atrash, Shebli, Holstein, Sarah A., Nadeem, Omar, Kaufman, Jonathan L., Joshi, Adarsh, Suryanarayan, Kaveri, Collins, Sabrina
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Abstract 5546: A murine reactive version of TAK-573 (anti-CD38 attenuated IFNα fusion protein) shows immunomodulatory and antitumor activity, alone and in combination with standard-of-care agents, in IFNa-insensitive, immunocompetent murine multiple myeloma tumor models
Hara, Tomoya, Wong, Christina, Yu, Jie, Collins, Sabrina, Wang, Haiqing, Sugimoto, Hiroshi, Zhang, Hong, Bjorck, Pia, Curley, Michael D.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Modakafusp Alfa (TAK-573), an Immunocytokine, Shows Clinical Activity in Patients with Relapsed/Refractory Multiple Myeloma; Updated Results from a First-in-Human Phase 1 Study
Vogl, Dan T., Kaufman, Jonathan L., Holstein, Sarah A., Atrash, Shebli, Nadeem, Omar, Janakiram, Murali, Suryanarayan, Kaveri, Liu, Yuyin, Collins, Sabrina, Parot, Xavier, Chaudhry, Maria
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
TAK-573, an Anti-CD38/Attenuated Ifnα Fusion Protein, Has Clinical Activity and Modulates the Ifnα Receptor (IFNAR) Pathway in Patients with Relapsed/Refractory Multiple Myeloma
Vogl, Dan T., Kaufman, Jonathan L., Holstein, Sara A., Nadeem, Omar, O'Donnell, Elizabeth, Suryanarayan, Kaveri, Collins, Sabrina, Parot, Xavier, Chaudhry, Maria
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Abstract CT065: Modakafusp alfa shows intratumoral immune pharmacodynamics (PD) in a subset of patients (pts) in a phase 1b study in advanced/metastatic solid tumors
Saggu, Gurpanna, Markman, Janet L., Lee, Min Young, Dunbar, Faith, Joshi, Adarsh, Wang, Shining, Collins, Sabrina
Published in Cancer research (Chicago, Ill.) (05.04.2024)
Published in Cancer research (Chicago, Ill.) (05.04.2024)
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Journal Article
P-198 Immunomodulatory Effects of Daratumumab on the Bone Marrow Microenvironment in Multiple Myeloma: Insights from Single-Cell Analyses
Bekri, Selma, Damle, Gargi, Demircioglu, Deniz, Kats, Simone, Kelly, Geoffrey, Dawson, Travis, Darwin, D'souza, Collins, Sabrina, Kim-Schulze, Seunghee, Gnjatic, Sacha, Parekh, Samir, Jagannath, Sundar, Lagana, Alessandro, Cho, Hearn Jay
Published in Clinical lymphoma, myeloma and leukemia (01.09.2024)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2024)
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Journal Article
a Phase 1b/2 Study of TAK-659, an Investigational Dual SYK and FLT-3 Inhibitor, in Patients (Pts) with Relapsed or Refractory Acute Myelogenous Leukemia (R/R AML)
Kaplan, Jason B, Bixby, Dale L., Morris, John C, Frankfurt, Olga, Altman, Jessica, Wise-Draper, Trisha, Burke, Patrick W., Collins, Sabrina, Kannan, Karuppiah, Wang, Ling, Faucette, Stephanie, Lee, Benjamin, Shou, Yaping, Levis, Mark J., Pratz, Keith W.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
PUB140 A Pilot Study to Assess Circulating Tumor Cells, Circulating Tumor Cell DNA and Cell Free DNA in Patients with Small Cell Lung Cancer
Aggarwal, Charu, Badola, Sunita, Shin, Hyunjin, Bedford, Lisa, Collins, Sabrina, Derk, Blair, Fostel, Jen, Ecsedy, Jeffrey, Evans, Tracey, Bauml, Joshua, Cohen, Roger, Vachani, Anil, Langer, Corey, Niu, Huifeng
Published in Journal of thoracic oncology (01.01.2017)
Published in Journal of thoracic oncology (01.01.2017)
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Journal Article
Abstract B213: Toward better preclinical combination studies: Using constrained optimization techniques in combination dosage and study design
Chen, Andrew, Collins, Sabrina, Mettetal, Jerome, Manfredi, Mark, Galvin, Katherine, Shyu, Wen Chyi, Ecsedy, Jeffrey, Palani, Santhosh, Chakravarty, Arijit
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
Abstract 3738: A rationale for combining the targeted investigational agents TAK-733, a MEK1/2 inhibitor, with alisertib (MLN8237), an Aurora A kinase inhibitor, for cancer therapy
Collins, Sabrina, Blair, Derek, Zarycki, Jodi, Szynal, Carmin, Gangolli, Esha, Vincent, Patrick, Chakravarty, Arijit, Ecsedy, Jeffrey
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract B136: Application of a mathematical model to understand the cell cycle progression effects of MEK1/2 kinase inhibition using the investigational small-molecule allosteric inhibitor TAK-733
Blair, Derek, Mettetal, Jay, Collins, Sabrina, Zarycki, Jodi, Vincent, Patrick, Ecsedy, Jeffrey, Chakravarty, Arijit
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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