NLRP3 and pyroptosis blockers for treating inflammatory diseases
Coll, Rebecca C., Schroder, Kate, Pelegrín, Pablo
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2022)
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2022)
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Journal Article
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
Coll, Rebecca C., Hill, James R., Day, Christopher J., Zamoshnikova, Alina, Boucher, Dave, Massey, Nicholas L., Chitty, Jessica L., Fraser, James A., Jennings, Michael P., Robertson, Avril A. B., Schroder, Kate
Published in Nature chemical biology (01.06.2019)
Published in Nature chemical biology (01.06.2019)
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Journal Article
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
Boucher, Dave, Monteleone, Mercedes, Coll, Rebecca C, Chen, Kaiwen W, Ross, Connie M, Teo, Jessica L, Gomez, Guillermo A, Holley, Caroline L, Bierschenk, Damien, Stacey, Katryn J, Yap, Alpha S, Bezbradica, Jelena S, Schroder, Kate
Published in The Journal of experimental medicine (05.03.2018)
Published in The Journal of experimental medicine (05.03.2018)
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Journal Article
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Coll, Rebecca C, Robertson, Avril A B, Chae, Jae Jin, Higgins, Sarah C, Muñoz-Planillo, Raúl, Inserra, Marco C, Vetter, Irina, Dungan, Lara S, Monks, Brian G, Stutz, Andrea, Croker, Daniel E, Butler, Mark S, Haneklaus, Moritz, Sutton, Caroline E, Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L, Mills, Kingston H G, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, O'Neill, Luke A J
Published in Nature medicine (01.03.2015)
Published in Nature medicine (01.03.2015)
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Journal Article
Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments
Haneklaus, Moritz, O’Neill, Luke AJ, Coll, Rebecca C
Published in Current opinion in immunology (01.02.2013)
Published in Current opinion in immunology (01.02.2013)
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Journal Article
The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype
Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A.B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng, List, Alan F.
Published in Blood (22.12.2016)
Published in Blood (22.12.2016)
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Journal Article
The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes
Coll, Rebecca C, Robertson, Avril, Butler, Mark, Cooper, Matthew, O'Neill, Luke A J
Published in PloS one (22.12.2011)
Published in PloS one (22.12.2011)
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Journal Article
The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes
Turton, Keren, Parks, Hannah J., Zarodkiewicz, Paulina, Hamad, Mohamad A., Dwane, Rachel, Parau, Georgiana, Ingram, Rebecca J., Coll, Rebecca C., Bryant, Clare E., Valvano, Miguel A.
Published in Cell reports (Cambridge) (29.08.2023)
Published in Cell reports (Cambridge) (29.08.2023)
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Journal Article
Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation
Wang, Wei, Dernst, Alesja, Martin, Bianca, Lorenzi, Lucia, Cadefau-Fabregat, Maria, Phulphagar, Kshiti, Wagener, Antonia, Budden, Christina, Stair, Neil, Wagner, Theresa, Färber, Harald, Jaensch, Andreas, Stahl, Rainer, Duthie, Fraser, Schmidt, Susanne V., Coll, Rebecca C., Meissner, Felix, Cuartero, Sergi, Latz, Eicke, Mangan, Matthew S.J.
Published in Cell reports (Cambridge) (24.09.2024)
Published in Cell reports (Cambridge) (24.09.2024)
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Journal Article
Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction
Greenhill, Claire J, Jones, Gareth W, Nowell, Mari A, Newton, Zarabeth, Harvey, Ann K, Moideen, Abdul N, Collins, Fraser L, Bloom, Anja C, Coll, Rebecca C, Robertson, Avril A B, Cooper, Matthew A, Rosas, Marcela, Taylor, Philip R, O'Neill, Luke A, Humphreys, Ian R, Williams, Anwen S, Jones, Simon A
Published in Arthritis research & therapy (30.08.2014)
Published in Arthritis research & therapy (30.08.2014)
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Journal Article
The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome
Domingo-Fernández, Raquel, Coll, Rebecca C., Kearney, Jay, Breit, Samuel, O'Neill, Luke A.J.
Published in The Journal of biological chemistry (21.07.2017)
Published in The Journal of biological chemistry (21.07.2017)
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Journal Article
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells
Arbore, Giuseppina, West, Erin E., Spolski, Rosanne, Robertson, Avril A. B., Klos, Andreas, Rheinheimer, Claudia, Dutow, Pavel, Woodruff, Trent M., Yu, Zu Xi, O'Neill, Luke A., Coll, Rebecca C., Sher, Alan, Leonard, Warren J., Köhl, Jörg, Monk, Pete, Cooper, Matthew A., Arno, Matthew, Afzali, Behdad, Lachmann, Helen J., Cope, Andrew P., Mayer-Barber, Katrin D., Kemper, Claudia
Published in Science (American Association for the Advancement of Science) (17.06.2016)
Published in Science (American Association for the Advancement of Science) (17.06.2016)
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