Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH
Allen, Eric L., Ulanet, Danielle B., Pirman, David, Mahoney, Christopher E., Coco, John, Si, Yaguang, Chen, Ying, Huang, Lingling, Ren, Jinmin, Choe, Sung, Clasquin, Michelle F., Artin, Erin, Fan, Zi Peng, Cianchetta, Giovanni, Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Smolen, Gromoslaw A.
Published in Cell reports (Cambridge) (11.10.2016)
Published in Cell reports (Cambridge) (11.10.2016)
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Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase
McDonald, Gabrielle, Chubukov, Victor, Coco, John, Truskowski, Kevin, Narayanaswamy, Rohini, Choe, Sung, Steadman, Mya, Artin, Erin, Padyana, Anil K, Jin, Lei, Ronseaux, Sebastien, Locuson, Charles, Fan, Zi-Peng, Erdmann, Tabea, Mann, Alan, Hayes, Sebastian, Fletcher, Mark, Nellore, Kavitha, Rao, Siva Sanjeeva, Subramanya, Hosahalli, Reddy, K Satish, Panigrahi, Sunil K, Antony, Thomas, Gopinath, Sreevalsam, Sui, Zhihua, Nagaraja, Nelamangala, Dang, Lenny, Lenz, Georg, Hurov, Jonathan, Biller, Scott A, Murtie, Josh, Marks, Kevin M, Ulanet, Danielle B
Published in Molecular cancer therapeutics (01.12.2020)
Published in Molecular cancer therapeutics (01.12.2020)
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Hematologic Malignancies Exhibit Selective Vulnerability to Inhibition of De Novo Pyrimidine Biosynthesis By AG-636, a Novel Inhibitor of Dihydroorotate Dehydrogenase in Phase 1 Clinical Trials
Ulanet, Danielle, Chubukov, Victor, Coco, John, McDonald, Gabrielle, Steadman, Mya, Narayanaswamy, Rohini, Ronseaux, Sebastien, Choe, Sung, Erdmann, Tabea, Truskowski, Kevin, Nellore, Kavitha, Rao, Siva Sanjeeva, Subramanya, Hosahalli, Lenz, Georg, Cooper, Michael, Murtie, Josh, Marks, Kevin
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Hsp90 (Heat Shock Protein 90) Inhibitor Occupancy Is a Direct Determinant of Client Protein Degradation and Tumor Growth Arrest in Vivo
Tillotson, Bonnie, Slocum, Kelly, Coco, John, Whitebread, Nigel, Thomas, Brian, West, Kip A., MacDougall, John, Ge, Jie, Ali, Janid A., Palombella, Vito J., Normant, Emmanuel, Adams, Julian, Fritz, Christian C.
Published in The Journal of biological chemistry (17.12.2010)
Published in The Journal of biological chemistry (17.12.2010)
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Abstract B145: The novel Hedgehog pathway inhibitor IPI-926 delays metastatic spread and provides a survival benefit in an experimental model of pancreatic liver metastasis
Coco, John, West, Kip, McGovern, Karen, Read, Margaret, MacDougall, John, Fritz, Christian
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Abstract 1891: Pharmacological target validation studies of fatty acid synthase in carcinoma using the potent, selective and orally bioavailable inhibitor IPI-9119
Brophy, Erin, Conley, James, O'Hearn, Patrick, Douglas, Mark, Cheung, Culver, Coco, John, D'Anello, Laura, Wylie, Andrew, Tibbitts, Thomas, Keaney, Gregg, Chan, Lawrence, Bahadoor, Adilah, Snyder, Dan, Nevalainen, Marta, Castro, Alfredo, Palombella, Vito, Loda, Massimo, Peluso, Stephane
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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