Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways
Bertinaria, Massimo, Pagliaro, Pasquale, Aragno, Manuela, Collino, Massimo, Cocco, Mattia, Alloatti, Giuseppe, Collotta, Debora, Serpe, Loredana, Chiazza, Fausto, Nigro, Debora, Penna, Claudia, Tullio, Francesca, Femminò, Saveria, Mastrocola, Raffaella
Published in Oxidative medicine and cellular longevity (01.01.2016)
Published in Oxidative medicine and cellular longevity (01.01.2016)
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Design, Synthesis, and Evaluation of Acrylamide Derivatives as Direct NLRP3 Inflammasome Inhibitors
Cocco, Mattia, Miglio, Gianluca, Giorgis, Marta, Garella, Davide, Marini, Elisabetta, Costale, Annalisa, Regazzoni, Luca, Vistoli, Giulio, Orioli, Marica, Massulaha-Ahmed, Raïhane, Détraz-Durieux, Isabelle, Groslambert, Marine, Py, Bénédicte F., Bertinaria, Massimo
Published in ChemMedChem (19.08.2016)
Published in ChemMedChem (19.08.2016)
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Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients
Spallotta Francesco, Cencioni Chiara, Atlante Sandra, Garella Davide, Cocco Mattia, Mori Mattia, Mastrocola Raffaella, Kuenne Carsten, Guenther, Stefan, Nanni Simona, Azzimato Valerio, Zukunft Sven, Kornberger, Angela, Duran, Sürün, Schnütgen Frank, von Melchner Harald, Di Stilo Antonella, Aragno Manuela, Braspenning Maarten, van Criekinge Wim, De Blasio Miles J, Ritchie, Rebecca H, Zaccagnini Germana, Martelli Fabio, Farsetti Antonella, Fleming, Ingrid, Braun, Thomas, Beiras-Fernandez Andres, Botta, Bruno, Collino Massimo, Bertinaria Massimo, Zeiher, Andreas M, Gaetano, Carlo
Published in Circulation research (05.01.2018)
Published in Circulation research (05.01.2018)
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Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease
Cocco, Mattia, Pellegrini, Carolina, Martínez-Banaclocha, Helios, Giorgis, Marta, Marini, Elisabetta, Costale, Annalisa, Miglio, Gianluca, Fornai, Matteo, Antonioli, Luca, López-Castejón, Gloria, Tapia-Abellán, Ana, Angosto, Diego, Hafner-Bratkovič, Iva, Regazzoni, Luca, Blandizzi, Corrado, Pelegrín, Pablo, Bertinaria, Massimo
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Electrophilic Warhead-Based Design of Compounds Preventing NLRP3 Inflammasome-Dependent Pyroptosis
Cocco, Mattia, Garella, Davide, Di Stilo, Antonella, Borretto, Emily, Stevanato, Livio, Giorgis, Marta, Marini, Elisabetta, Fantozzi, Roberto, Miglio, Gianluca, Bertinaria, Massimo
Published in Journal of medicinal chemistry (26.12.2014)
Published in Journal of medicinal chemistry (26.12.2014)
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Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target
Wilson, Caroline, Ray, Peter, Zuccotto, Fabio, Hernandez, Jorge, Aggarwal, Anup, Mackenzie, Claire, Caldwell, Nicola, Taylor, Malcolm, Huggett, Margaret, Mathieson, Michael, Murugesan, Dinakaran, Smith, Alasdair, Davis, Susan, Cocco, Mattia, Parai, Maloy K, Acharya, Arjun, Tamaki, Fabio, Scullion, Paul, Epemolu, Ola, Riley, Jennifer, Stojanovski, Laste, Lopez-Román, Eva Maria, Torres-Gómez, Pedro Alfonso, Toledo, Ana Maria, Guijarro-Lopez, Laura, Camino, Isabel, Engelhart, Curtis A, Schnappinger, Dirk, Massoudi, Lisa M, Lenaerts, Anne, Robertson, Gregory T, Walpole, Chris, Matthews, David, Floyd, David, Sacchettini, James C, Read, Kevin D, Encinas, Lourdes, Bates, Robert H, Green, Simon R, Wyatt, Paul G
Published in Journal of medicinal chemistry (13.01.2022)
Published in Journal of medicinal chemistry (13.01.2022)
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Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy
Caldwell, Nicola, Peet, Caroline, Miller, Peter, Colon, Beatrice L, Taylor, Malcolm G, Cocco, Mattia, Dawson, Alice, Lukac, Iva, Teixeira, Jose E, Robinson, Lee, Frame, Laura, Seizova, Simona, Damerow, Sebastian, Tamaki, Fabio, Post, John, Riley, Jennifer, Mutter, Nicole, Hanna, Jack C, Ferguson, Liam, Hu, Xiao, Tinti, Michele, Forte, Barbara, Norcross, Neil R, Campbell, Peter S, Svensen, Nina, Caldwell, Flora C, Jansen, Chimed, Postis, Vincent, Read, Kevin D, Huston, Christopher D, Gilbert, Ian H, Baragaña, Beatriz, Pawlowic, Mattie C
Published in Science translational medicine (23.10.2024)
Published in Science translational medicine (23.10.2024)
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Journal Article
Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation
Spallotta, Francesco, Cencioni, Chiara, Atlante, Sandra, Garella, Davide, Cocco, Mattia, Mori, Mattia, Mastrocola, Raffaella, Kuenne, Carsten, Guenther, Stefan, Nanni, Simona, Azzimato, Valerio, Zukunft, Sven, Kornberger, Angela, Sürün, Duran, Schnütgen, Frank, von Melchner, Harald, Di Stilo, Antonella, Aragno, Manuela, Braspenning, Maarten, van Criekinge, Wim, De Blasio, Miles J, Ritchie, Rebecca H, Zaccagnini, Germana, Martelli, Fabio, Farsetti, Antonella, Fleming, Ingrid, Braun, Thomas, Beiras-Fernandez, Andres, Botta, Bruno, Collino, Massimo, Bertinaria, Massimo, Zeiher, Andreas M, Gaetano, Carlo
Published in Circulation research (05.01.2018)
Published in Circulation research (05.01.2018)
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Journal Article
Tu1889 Targeting of NLRP3 Inflammasome With a Novel Selective Inhibitor as a Suitable Strategy for the Pharmacological Treatment of Bowel Inflammation
Pellegrini, Carolina, Fornai, Matteo, Colucci, Rocchina, Lopez-Castejon, Gloria, Cocco, Mattia, Garella, Davide, Bertinaria, Massimo, Blandizzi, Corrado, Antonioli, Luca
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2016)
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Journal Article
Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors
Garella, Davide, Atlante, Sandra, Borretto, Emily, Cocco, Mattia, Giorgis, Marta, Costale, Annalisa, Stevanato, Livio, Miglio, Gianluca, Cencioni, Chiara, Fernández-de Gortari, Eli, Medina-Franco, José L., Spallotta, Francesco, Gaetano, Carlo, Bertinaria, Massimo
Published in Chemical biology & drug design (01.11.2016)
Published in Chemical biology & drug design (01.11.2016)
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Journal Article
ANTI-INFECTIVE AGENTS
TAYLOR, Malcolm, JANSEN, Chimed, COCCO, Mattia, GILBERT, Ian Hugh, CALDWELL, Nicola, BARAGAÑA RUIBAL, Beatriz, FORTE, Barbara
Year of Publication 02.11.2023
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Year of Publication 02.11.2023
Patent
Abstract 19033: Cardiac Epi-Metabolic Signature Revealed by Integrated Omics Approach in Diabetic Patients: Rescue by Active DNA Demethylation via TET-TDG Complex Reactivation
Spallotta, Francesco, Cencioni, Chiara, Atlante, Sandra, Garella, Davide, Cocco, Mattia, Mori, Mattia, Mastrocola, Raffaella, Kuenne, Carsten, Guenther, Stefan, Nanni, Simona, Azzimato, Valerio, Zukunft, Sven, Kornberger, Angela, Di Stilo, Antonella, Aragno, Manuela, Martelli, Fabio, Farsetti, Antonella, Fleming, Ingrid, Braun, Thomas, Beiras-Fernandez, Andres, Botta, Bruno, Collino, Massimo, Bertinaria, Massimo, Zeiher, Andreas M, Gaetano, Carlo
Published in Circulation (New York, N.Y.) (11.11.2016)
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Published in Circulation (New York, N.Y.) (11.11.2016)
Journal Article
CONJUGATES COMPRISING CLEAVABLE LINKERS
MASTERSON, Luke, COCCO, Mattia, DENG, Boliang, KHAN, Akbar Husain, GALAN COCA, Albano, PRYYMA, Alla, BARTOLO, Nicole Danielle, MADERNA, Andreas Lothar Severino, BEADLE, Jonathan David, GOUNDRY, William Robert Fraser, LEE, Maximillian Taro William
Year of Publication 07.11.2024
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Year of Publication 07.11.2024
Patent
CONJUGATES COMPRISING CLEAVABLE LINKERS
MASTERSON, Luke, COCCO, Mattia, DENG, Boliang, KHAN, Akbar Husain, GALAN COCA, Albano, PRYYMA, Alla, BARTOLO, Nicole Danielle, MADERNA, Andreas Lothar Severino, BEADLE, Jonathan David, GOUNDRY, William Robert Fraser, LEE, Maximillian Taro William
Year of Publication 24.10.2024
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Year of Publication 24.10.2024
Patent