Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design
Peat, Thomas S, Rhodes, David I, Vandegraaff, Nick, Le, Giang, Smith, Jessica A, Clark, Lisa J, Jones, Eric D, Coates, Jonathan A V, Thienthong, Neeranat, Newman, Janet, Dolezal, Olan, Mulder, Roger, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J
Published in PloS one (10.07.2012)
Published in PloS one (10.07.2012)
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Antiviral agents 3. Discovery of a novel small molecule non-nucleoside inhibitor of Hepatitis B Virus (HBV)
Crosby, Ian T., Bourke, David G., Jones, Eric D., Jeynes, Tyrone P., Cox, Susan, Coates, Jonathan A.V., Robertson, Alan D.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold
Jones, Eric D., Vandegraaff, Nick, Le, Giang, Choi, Neil, Issa, William, Macfarlane, Katherine, Thienthong, Neeranat, Winfield, Lisa J., Coates, Jonathan A.V., Lu, Long, Li, Xinming, Feng, Xiao, Yu, Changjiang, Rhodes, David I., Deadman, John J.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators
Le, Giang, Vandegraaff, Nick, Rhodes, David I., Jones, Eric D., Coates, Jonathan A.V., Thienthong, Neeranat, Winfield, Lisa J., Lu, Long, Li, Xinming, Yu, Changjiang, Feng, Xiao, Deadman, John J.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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Antiviral agents 2. Synthesis of trimeric naphthoquinone analogues of conocurvone and their antiviral evaluation against HIV
Crosby, Ian T., Bourke, David G., Jones, Eric D., de Bruyn, Paula J., Rhodes, David, Vandegraaff, Nick, Cox, Susan, Coates, Jonathan A.V., Robertson, Alan D.
Published in Bioorganic & medicinal chemistry (01.09.2010)
Published in Bioorganic & medicinal chemistry (01.09.2010)
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Discovery of potent HIV integrase inhibitors active against raltegravir resistant viruses
Le, Giang, Vandegraaff, Nick, Rhodes, David I., Jones, Eric D., Coates, Jonathan A.V., Lu, Long, Li, Xinming, Yu, Changjiang, Feng, Xiao, Deadman, John J.
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
Peat, Thomas S., Rhodes, David I., Vandegraaff, Nick, Le, Giang, Smith, Jessica A., Clark, Lisa J., Jones, Eric D., Coates, Jonathan A. V., Thienthong, Neeranat, Newman, Janet, Dolezal, Olan, Mulder, Roger, Ryan, John H., Savage, G. Paul, Francis, Craig L., Deadman, John J.
Published in PloS one (24.07.2013)
Published in PloS one (24.07.2013)
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Crystal Structures of Novel Allosteric Peptide Inhibitors of HIV Integrase Identify New Interactions at the LEDGF Binding Site
Rhodes, David I., Peat, Thomas S., Vandegraaff, Nick, Jeevarajah, Dharshini, Newman, Janet, Martyn, John, Coates, Jonathan A. V., Ede, Nicholas J., Rea, Philip, Deadman, John J.
Published in Chembiochem : a European journal of chemical biology (17.10.2011)
Published in Chembiochem : a European journal of chemical biology (17.10.2011)
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Structural Basis for a New Mechanism of Inhibition of H I V-1 Integrase Identified by Fragment Screening and Structure-Based Design
Rhodes, David I, Peat, Thomas S, Vandegraaff, Nick, Jeevarajah, Dharshini, Le, Giang, Jones, Eric D, Smith, Jessica A, Coates, Jonathan AV, Winfeld, Lisa J, Thienthong, Neeranat, Newman, Janet, Lucent, Del, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J
Published in Antiviral chemistry & chemotherapy (01.04.2011)
Published in Antiviral chemistry & chemotherapy (01.04.2011)
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Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil
Borthwick, Alan D, Evans, Derek N, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Youds, Peter, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V
Published in Journal of medicinal chemistry (01.01.1990)
Published in Journal of medicinal chemistry (01.01.1990)
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Penicillin derived C2-symmetric dimers as novel inhibitors of HIV-1 proteinase
Humber, David C, Cammack, Nicholas, Coates, Jonathan A. V, Cobley, Kevin N, Orr, David C, Storer, Richard, Weingarten, Gordon G, Weir, Malcolm P
Published in Journal of medicinal chemistry (01.08.1992)
Published in Journal of medicinal chemistry (01.08.1992)
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Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design
Rhodes, David I, Peat, Thomas S, Vandegraaff, Nick, Jeevarajah, Dharshini, Le, Giang, Jones, Eric D, Smith, Jessica A, Coates, Jonathan A V, Winfield, Lisa J, Thienthong, Neeranat, Newman, Janet, Lucent, Del, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J
Published in Antiviral chemistry & chemotherapy (07.03.2011)
Published in Antiviral chemistry & chemotherapy (07.03.2011)
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Fluorocarbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxyguanosines
Borthwick, Alan D, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Butt, Suzanne, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V, Ryan, D. Michael
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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ChemInform Abstract: Antiviral Agents. Part 3. Discovery of a Novel Small Molecule Non-Nucleoside Inhibitor of Hepatitis B Virus (HBV)
Crosby, Ian T., Bourke, David G., Jones, Eric D., Jeynes, Tyrone P., Cox, Susan, Coates, Jonathan A. V., Robertson, Alan D.
Published in ChemInform (12.07.2011)
Published in ChemInform (12.07.2011)
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COMPOSITION COMPRISING THE (-) ENANTIOMER OF CIS-4-AMINO-1-(2-HYDROMETHYL-1,3-OXATHIOLAN-5-YL)-(1H)-PYRIMIDINE-2-ONE OR AN ENRICHED COMPOSITION THEREOF, AND ITS USES AS A PHARMACEUTICAL AGENT
PENN, CHARLES R, COATES, JONATHAN A. V, MUTTON, IAN M, WILLIAMSON, CHRISTOPHER, STORER, RICHARD
Year of Publication 10.04.2001
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Year of Publication 10.04.2001
Patent
METHOD OF OBTAINING NUCLEOSIDE ANALOGS OF 1,3-OXATHIOLANE
PENN CHARLES R, MUTTON IAN M, STORER RICHARD, COATES JONATHAN A. V, WILLIAMSON CHRISTOPHER
Year of Publication 31.10.1995
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Year of Publication 31.10.1995
Patent
COMPOSITION COMPRISING THE (-) ENANTIOMER OF CIS-4-AMINO-1-(2-HYDROMETHYL-1,3-OXATHIOLAN-5-YL)-(1H)-PYRIMIDINE-2-ONE OR AN ENRICHED COMPOSITION THEREOF, AND ITS USES AS A PHARMACEUTICAL AGENT
PENN, CHARLES R, COATES, JONATHAN A. V, MUTTON, IAN M, WILLIAMSON, CHRISTOPHER, STORER, RICHARD
Year of Publication 03.11.1991
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Year of Publication 03.11.1991
Patent