Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver
Andersen, Melvin E., Black, Michael B., Campbell, Jerry L., Pendse, Salil N., Clewell III, Harvey J., Pottenger, Lynn H., Bus, James S., Dodd, Darol E., Kemp, Daniel C., McMullen, Patrick D.
Published in Toxicology and applied pharmacology (01.10.2017)
Published in Toxicology and applied pharmacology (01.10.2017)
Get full text
Journal Article
Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods
Nicolas, Chantel I., Linakis, Matthew W., Minto, Melyssa S., Mansouri, Kamel, Clewell, Rebecca A., Yoon, Miyoung, Wambaugh, John F., Patlewicz, Grace, McMullen, Patrick D., Andersen, Melvin E., Clewell III, Harvey J.
Published in Frontiers in pharmacology (07.10.2022)
Published in Frontiers in pharmacology (07.10.2022)
Get full text
Journal Article
Analysis of genomic dose-response information on arsenic to inform key events in a mode of action for carcinogenicity
Gentry, P. Robinan, McDonald, Tracy B, Sullivan, Dexter E, Shipp, Annette M, Yager, Janice W, Clewell, Harvey J. III
Published in Environmental and molecular mutagenesis (01.01.2010)
Published in Environmental and molecular mutagenesis (01.01.2010)
Get full text
Journal Article
Bayesian Estimation of Pharmacokinetic and Pharmacodynamic Parameters in a Mode-of-Action-Based Cancer Risk Assessment for Chloroform
Liao, Kai H, Tan, Yu-Mei, Conolly, Rory B, Borghoff, Susan J, Gargas, Michael L, Andersen, Melvin E, Clewell, Harvey J. III
Published in Risk analysis (01.12.2007)
Published in Risk analysis (01.12.2007)
Get full text
Journal Article
Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics?
Verner, Marc-André, McDougall, Robin, Glynn, Anders, Andersen, Melvin E, Clewell, 3rd, Harvey J, Longnecker, Matthew P
Published in Environmental health perspectives (01.10.2013)
Published in Environmental health perspectives (01.10.2013)
Get full text
Journal Article
Using quantitative modeling tools to assess pharmacokinetic bias in epidemiological studies showing associations between biomarkers and health outcomes at low exposures
Andersen, Melvin E., Mallick, Pankajini, Clewell, Harvey J., Yoon, Miyoung, Olsen, Geary W., Longnecker, Matthew P.
Published in Environmental research (01.06.2021)
Published in Environmental research (01.06.2021)
Get full text
Journal Article
Comparison of Tissue Dosimetry in the Mouse Following Chronic Exposure to Arsenic Compounds
Gentry, P. Robinan, Covington, Tammie R., Lawrence, Greg, McDonald, Tracy, Snow, Elizabeth T., Germolec, Dori, Moser, Glenda, Yager, Janice W., Clewell III, Harvey J.
Published in Journal of Toxicology and Environmental Health, Part A (12.03.2005)
Published in Journal of Toxicology and Environmental Health, Part A (12.03.2005)
Get full text
Journal Article
A Kinetic Analysis of DNA-Deoxy Guanine Adducts in the Nasal Epithelium Produced by Inhaled Formaldehyde in Rats—Assessing Contributions to Adduct Production From Both Endogenous and Exogenous Sources of Formaldehyde
Campbell Jr, Jerry L, Gentry, P Robinan, Clewell III, Harvey J, Andersen, Melvin E
Published in Toxicological sciences (01.10.2020)
Published in Toxicological sciences (01.10.2020)
Get full text
Journal Article
Incorporation of rapid association/dissociation processes in tissues into the monkey and human physiologically based pharmacokinetic models for manganese
Campbell, Jerry L, Clewell, Harvey J, Van Landingham, Cynthia, Gentry, P Robinan, Keene, Athena M, Taylor, Michael D, Andersen, Melvin E
Published in Toxicological sciences (17.02.2023)
Published in Toxicological sciences (17.02.2023)
Get full text
Journal Article
Paraquat pharmacokinetics in primates and extrapolation to humans
Stevens, Alexander J., Campbell, Jerry L., Travis, Kim Z., Clewell, Harvey J., Hinderliter, Paul M., Botham, Philip A., Cook, Andrew R., Minnema, Daniel J., Wolf, Douglas C.
Published in Toxicology and applied pharmacology (15.04.2021)
Published in Toxicology and applied pharmacology (15.04.2021)
Get full text
Journal Article
Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates
Clewell, Rebecca A., Leonard, Jeremy A., Nicolas, Chantel I., Campbell, Jerry L., Yoon, Miyoung, Efremenko, Alina Y., McMullen, Patrick D., Andersen, Melvin E., Clewell, Harvey J., Phillips, Katherine A., Tan, Yu-Mei
Published in Toxicology in vitro (01.08.2020)
Published in Toxicology in vitro (01.08.2020)
Get full text
Journal Article
Integration of paraquat pharmacokinetic data across species using PBPK modelling
Campbell, Jerry L., Travis, Kim Z., Clewell, Harvey J., Stevens, Alexander J., Hinderliter, Paul M., Andersen, Melvin E., Botham, Philip A., Cook, Andrew R., Minnema, Daniel J., Wolf, Douglas C.
Published in Toxicology and applied pharmacology (15.04.2021)
Published in Toxicology and applied pharmacology (15.04.2021)
Get full text
Journal Article
Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse
Chiu, Weihsueh A, Campbell, Jr, Jerry L, Clewell, 3rd, Harvey J, Zhou, Yi-Hui, Wright, Fred A, Guyton, Kathryn Z, Rusyn, Ivan
Published in Environmental health perspectives (01.05.2014)
Published in Environmental health perspectives (01.05.2014)
Get full text
Journal Article
Pharmacokinetic modeling of saturable, renal resorption of perfluoroalkylacids in monkeys—Probing the determinants of long plasma half-lives
Andersen, Melvin E., Clewell, Harvey J., Tan, Yu-Mei, Butenhoff, John L., Olsen, Geary W.
Published in Toxicology (Amsterdam) (03.10.2006)
Published in Toxicology (Amsterdam) (03.10.2006)
Get full text
Journal Article