Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment
Farm, Hui Jia, Clerx, Michael, Cooper, Fergus, Polonchuk, Liudmila, Wang, Ken, Gavaghan, David J, Lei, Chon Lok
Published in Frontiers in pharmacology (20.03.2023)
Published in Frontiers in pharmacology (20.03.2023)
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Journal Article
Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology
Lei, Chon Lok, Wang, Ken, Clerx, Michael, Johnstone, Ross H, Hortigon-Vinagre, Maria P, Zamora, Victor, Allan, Andrew, Smith, Godfrey L, Gavaghan, David J, Mirams, Gary R, Polonchuk, Liudmila
Published in Frontiers in physiology (12.12.2017)
Published in Frontiers in physiology (12.12.2017)
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Journal Article
Predicting changes to INa from missense mutations in human SCN5A
Clerx, Michael, Heijman, Jordi, Collins, Pieter, Volders, Paul G. A.
Published in Scientific reports (24.08.2018)
Published in Scientific reports (24.08.2018)
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Journal Article
A Parameter Representing Missing Charge Should Be Considered when Calibrating Action Potential Models
Barral, Yann-Stanislas H M, Shuttleworth, Joseph G, Clerx, Michael, Whittaker, Dominic G, Wang, Ken, Polonchuk, Liudmila, Gavaghan, David J, Mirams, Gary R
Published in Frontiers in physiology (26.04.2022)
Published in Frontiers in physiology (26.04.2022)
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Journal Article
Probabilistic Inference on Noisy Time Series (PINTS)
Clerx, Michael, Robinson, Martin, Lambert, Ben, Lei, Chon Lok, Ghosh, Sanmitra, Mirams, Gary R., Gavaghan, David J.
Published in Journal of open research software (19.07.2019)
Published in Journal of open research software (19.07.2019)
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Journal Article
CellML 2.0.1
Clerx, Michael, Cooling, Michael T., Cooper, Jonathan, Garny, Alan, Moyle, Keri, Nickerson, David P., Nielsen, Poul M. F., Sorby, Hugh
Published in Journal of integrative bioinformatics (31.03.2023)
Published in Journal of integrative bioinformatics (31.03.2023)
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Journal Article
CellML 2.0
Clerx, Michael, Cooling, Michael T., Cooper, Jonathan, Garny, Alan, Moyle, Keri, Nickerson, David P., Nielsen, Poul M. F., Sorby, Hugh
Published in Journal of integrative bioinformatics (24.07.2020)
Published in Journal of integrative bioinformatics (24.07.2020)
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Journal Article
cellmlmanip and chaste_codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians
Hendrix, Maurice, Clerx, Michael, Tamuri, Asif U, Keating, Sarah M, Johnstone, Ross H, Cooper, Jonathan, Mirams, Gary R
Published in Wellcome open research (2021)
Published in Wellcome open research (2021)
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Journal Article
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer
Lei, Chon Lok, Fabbri, Alan, Whittaker, Dominic G., Clerx, Michael, Windley, Monique J., Hill, Adam P., Mirams, Gary R., de Boer, Teun P.
Published in Wellcome open research (01.01.2020)
Published in Wellcome open research (01.01.2020)
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Journal Article
chaste codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians
Hendrix, Maurice, Clerx, Michael, Tamuri, Asif U, Keating, Sarah M, Johnstone, Ross H, Cooper, Jonathan, Mirams, Gary R
Published in Wellcome open research (2021)
Published in Wellcome open research (2021)
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Journal Article
Four Ways to Fit an Ion Channel Model
Clerx, Michael, Beattie, Kylie A., Gavaghan, David J., Mirams, Gary R.
Published in Biophysical journal (17.12.2019)
Published in Biophysical journal (17.12.2019)
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Journal Article
Predicted drug effects on the action potential vary significantly with different models
Farm, Hui Jia, Clerx, Michael, Cooper, Fergus, Polonchuk, Liudmila, Wang, Ken, Gavaghan, David, Lei, Chon Lok
Published in Biophysical journal (08.02.2024)
Published in Biophysical journal (08.02.2024)
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Journal Article
Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System
Lei, Chon Lok, Clerx, Michael, Gavaghan, David J., Polonchuk, Liudmila, Mirams, Gary R., Wang, Ken
Published in Biophysical journal (17.12.2019)
Published in Biophysical journal (17.12.2019)
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Journal Article
Myokit: A simple interface to cardiac cellular electrophysiology
Clerx, Michael, Collins, Pieter, de Lange, Enno, Volders, Paul G.A.
Published in Progress in biophysics and molecular biology (01.01.2016)
Published in Progress in biophysics and molecular biology (01.01.2016)
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Journal Article
Autocorrelated measurement processes and inference for ordinary differential equation models of biological systems
Lambert, Ben, Lei, Chon Lok, Robinson, Martin, Clerx, Michael, Creswell, Richard, Ghosh, Sanmitra, Tavener, Simon, Gavaghan, David J.
Published in Journal of the Royal Society interface (22.02.2023)
Published in Journal of the Royal Society interface (22.02.2023)
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Journal Article
Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence
Lei, Chon Lok, Clerx, Michael, Beattie, Kylie A., Melgari, Dario, Hancox, Jules C., Gavaghan, David J., Polonchuk, Liudmila, Wang, Ken, Mirams, Gary R.
Published in Biophysical journal (17.12.2019)
Published in Biophysical journal (17.12.2019)
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Journal Article
Predicting changes to I Na from missense mutations in human SCN5A
Clerx, Michael, Heijman, Jordi, Collins, Pieter, Volders, Paul G A
Published in Scientific reports (24.08.2018)
Published in Scientific reports (24.08.2018)
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Journal Article