Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)
Strotman, Neil A, Baxter, Carl A, Brands, Karel M. J, Cleator, Ed, Krska, Shane W, Reamer, Robert A, Wallace, Debra J, Wright, Timothy J
Published in Journal of the American Chemical Society (01.06.2011)
Published in Journal of the American Chemical Society (01.06.2011)
Get full text
Journal Article
Two Approaches to the Chemical Development and Large-Scale Preparation of a Pyrimidyl Tetrazole Intermediate
Mullens, Peter, Cleator, Ed, McLaughlin, Mark, Bishop, Brian, Edwards, John, Goodyear, Adrian, Andreani, Teresa, Jin, Yan, Kong, Jongrock, Li, Hongmei, Williams, Michael, Zacuto, Michael
Published in Organic process research & development (17.06.2016)
Published in Organic process research & development (17.06.2016)
Get full text
Journal Article
Intramolecular Cyclopropanation of Unsaturated Terminal Epoxides and Chlorohydrins
Hodgson, David M, Chung, Ying Kit, Nuzzo, Irene, Freixas, Glòria, Kulikiewicz, Krystyna K, Cleator, Ed, Paris, Jean-Marc
Published in Journal of the American Chemical Society (11.04.2007)
Published in Journal of the American Chemical Society (11.04.2007)
Get full text
Journal Article
Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub-Nanomolar SERCA Inhibition
Andrews, Stephen P., Ball, Matthew, Wierschem, Frank, Cleator, Ed, Oliver, Steven, Högenauer, Klemens, Simic, Oliver, Antonello, Alessandra, Hünger, Udo, Smith, Martin D., Ley, Steven V.
Published in Chemistry : a European journal (06.07.2007)
Published in Chemistry : a European journal (06.07.2007)
Get full text
Journal Article
A Novel Approach to 3-Methylindoles by a Heck/Cyclization/Isomerization Process
Baxter, Carl A, Cleator, Ed, Alam, Mahbub, Davies, Antony J, Goodyear, Adrian, O’Hagan, Michael
Published in Organic letters (19.02.2010)
Published in Organic letters (19.02.2010)
Get full text
Journal Article
Total Synthesis of Thapsigargin, a Potent SERCA Pump Inhibitor
Ball, Matthew, Andrews, Stephen P, Wierschem, Frank, Cleator, Ed, Smith, Martin D, Ley, Steven V
Published in Organic letters (15.02.2007)
Published in Organic letters (15.02.2007)
Get full text
Journal Article
Enantio- and diastereoselective Michael additions of C-succinimidyl esters to nitro olefins using cinchonine-derived bifunctional organocatalysts
Jakubec, Pavol, Cockfield, Dane M., Hynes, Peter S., Cleator, Ed, Dixon, Darren J.
Published in Tetrahedron: asymmetry (01.06.2011)
Published in Tetrahedron: asymmetry (01.06.2011)
Get full text
Journal Article
Synthesis of the thapsigargins
Ley, S.V, Antonello, A, Balskus, E.P, Booth, D.T, Christensen, S.B, Cleator, E, Gold, H, Hogenauer, K, Hunger, U, Myers, R.M
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (17.08.2004)
Get full text
Journal Article
The synthesis of functionalised chiral bicyclic lactam and lactone N-oxides using a tandem Cope elimination/reverse Cope elimination protocol
Ellis, Gemma L., O’Neil, Ian A., Elena Ramos, V., Cleator, Ed, Barret Kalindjian, S., Chorlton, Alan P., Tapolczay, David J.
Published in Tetrahedron letters (05.03.2007)
Published in Tetrahedron letters (05.03.2007)
Get full text
Journal Article
Pd/C Catalyzed Dehalogenation of (Hetero)aryls Using Triethyl-silane as Hydrogen Donor
La Torre, Matheo, Maton, William, Cleator, Ed, Jouffroy, Matthieu
Published in Synthesis (Stuttgart) (03.05.2023)
Published in Synthesis (Stuttgart) (03.05.2023)
Get more information
Journal Article
Process Development of a Tricyclic Diazepine-Based IDH1 Mutant Inhibitor
Maddess, Matthew L., Cleator, Ed, Morimoto, Mariko, Goodyear, Adrian, Dieguez-Vazquez, Alejandro, Gibb, Andrew, Kirtley, Andy, Christensen, Melodie, Song, Chaohui, Peng, Feng, Alam, Mahbub, Keen, Stephen P., Oliver, Steven F.
Published in Organic process research & development (21.06.2024)
Published in Organic process research & development (21.06.2024)
Get full text
Journal Article
High-Throughput Experimentation Enabling Rapid Process Optimization of an RSV Drug Candidate
Jusseau, Xavier, Cleator, Ed, Maton, William M., Chen, Qinghao, Geertman, Robert, Yuan, Yuanyuan, Wang, Xiaowei, Wei, Haojuan, Medina, Florian, Giannerini, Massimo
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
Get full text
Journal Article
Total synthesis of (-)-nakadomarin A
Kyle, Andrew F., Jakubec, Pavol, Cockfield, Dane M., Cleator, Ed, Skidmore, John, Dixon, Darren J.
Published in Chemical communications (Cambridge, England) (28.09.2011)
Published in Chemical communications (Cambridge, England) (28.09.2011)
Get full text
Journal Article
Development of a Stereoselective Synthesis of (1R,4R)- and (1S,4S)‑2-Oxa-5-azabicyclo[2.2.2]octane
Maddess, Matthew L, Cleator, Ed, Morimoto, Mariko, Goodyear, Adrian, Dieguez-Vazquez, Alejandro, Gibb, Andrew, Kirtley, Andy, Wang, Jie, Qi, Ji, Kong, Lingzhu, Alam, Mahbub, Keen, Stephen, Oliver, Steven F, Wen, Xin, Lam, Yu-Hong
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
Get full text
Journal Article
Asymmetric Synthesis of cis-2,5-Disubstituted Pyrrolidine, the Core Scaffold of beta(3)-AR Agonists
Xu, Feng, Chung, John Y. L., Moore, Jeffery C., Liu, Zhuqing, Yoshikawa, Naoki, Hoerrner, R. Scott, Lee, Jaemoon, Royzen, Maksim, Cleator, Ed, Gibson, Andrew G., Dunn, Robert, Maloney, Kevin M., Alam, Mahbub, Goodyear, Adrian, Lynch, Joseph, Yasuda, Nobuyashi, Devine, Paul N.
Published in Organic letters (15.03.2013)
Published in Organic letters (15.03.2013)
Get full text
Journal Article
Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor
Zhong, Yong-Li, Cleator, Ed, Liu, Zhijian, Yin, Jianguo, Morris, William J, Alam, Mahbub, Bishop, Brian, Dumas, Aaron M, Edwards, John, Goodyear, Adrian, Mullens, Peter, Song, Zhiguo Jake, Shevlin, Michael, Thaisrivongs, David A, Li, Hongming, Sherer, Edward C, Cohen, Ryan D, Yin, Jingjun, Tan, Lushi, Yasuda, Nobuyoshi, Limanto, John, Davies, Antony, Campos, Kevin R
Published in Journal of organic chemistry (19.04.2019)
Published in Journal of organic chemistry (19.04.2019)
Get full text
Journal Article
The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder
Baxter, Carl A, Cleator, Ed, Brands, Karel M. J, Edwards, John S, Reamer, Robert A, Sheen, Faye J, Stewart, Gavin W, Strotman, Neil A, Wallace, Debra J
Published in Organic process research & development (18.03.2011)
Published in Organic process research & development (18.03.2011)
Get full text
Journal Article