RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis
Brünker, Peter, Wartha, Katharina, Friess, Thomas, Grau-Richards, Sandra, Waldhauer, Inja, Koller, Claudia Ferrara, Weiser, Barbara, Majety, Meher, Runza, Valeria, Niu, Huifeng, Packman, Kathryn, Feng, Ningping, Daouti, Sherif, Hosse, Ralf J, Mössner, Ekkehard, Weber, Thomas G, Herting, Frank, Scheuer, Werner, Sade, Hadassah, Shao, Cuiying, Liu, Bin, Wang, Peng, Xu, Gary, Vega-Harring, Suzana, Klein, Christian, Bosslet, Klaus, Umaña, Pablo
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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Journal Article
Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics
Tyshchuk, Oksana, Gstöttner, Christoph, Funk, Dennis, Nicolardi, Simone, Frost, Stefan, Klostermann, Stefan, Becker, Tim, Jolkver, Elena, Schumacher, Felix, Koller, Claudia Ferrara, Völger, Hans Rainer, Wuhrer, Manfred, Bulau, Patrick, Mølhøj, Michael
Published in mAbs (03.10.2019)
Published in mAbs (03.10.2019)
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Journal Article
Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer
Trüb, Marta, Uhlenbrock, Franziska, Claus, Christina, Herzig, Petra, Thelen, Martin, Karanikas, Vaios, Bacac, Marina, Amann, Maria, Albrecht, Rosemarie, Ferrara-Koller, Claudia, Thommen, Daniela, Rothschield, Sacha, Savic Prince, Spasenija, Mertz, Kirsten D, Cathomas, Gieri, Rosenberg, Robert, Heinzelmann-Schwarz, Viola, Wiese, Mark, Lardinois, Didier, Umana, Pablo, Klein, Christian, Laubli, Heinz, Kashyap, Abhishek S, Zippelius, Alfred
Published in Journal for immunotherapy of cancer (01.07.2020)
Published in Journal for immunotherapy of cancer (01.07.2020)
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Journal Article
HUMANIZED ANTI-HUMAN CD19 ANTIBODIES AND METHODS OF USE
CLAUDIA FERRARA KOLLER, LAURENT LARIVIERE, MICHAEL MOLHOJ, ALEXANDER HAAS, TILMAN SCHLOTHAUER, KETTENBERGER HUBERT, MOESSNER EKKEHARD, GUY GEORGES
Year of Publication 09.04.2020
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Year of Publication 09.04.2020
Patent
Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions
Schlothauer, Tilman, Herter, Sylvia, Koller, Claudia Ferrara, Grau-Richards, Sandra, Steinhart, Virginie, Spick, Christian, Kubbies, Manfred, Klein, Christian, Umaña, Pablo, Mössner, Ekkehard
Published in Protein engineering, design and selection (01.10.2016)
Published in Protein engineering, design and selection (01.10.2016)
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Journal Article
BISPECIFIC ANTIBODIES SPECIFIC FOR FAP AND DR5, ANTIBODIES SPECIFIC FOR DR5 AND METHODS OF USE
STEFAN SEEBER, SHERIF DAOUTI, JOERG MOELLEKEN, CLAUDIA FERRARA KOLLER, CHRISTIAN KLEIN, NIU HUIFENG, MAXIMILIANE KOENIG, FENG NINGPING, VALERIA RUNZA, INJA WALDHAUER, KATHRYN E PACKMAN, PETER BRUENKER, WANG HUISHENG, SANDRA GRAU-RICHARDS, RALF HOSSE, BARBARA WEISER, MOESSNER EKKEHARD, PABLO UMANA, GUY GEORGES
Year of Publication 29.03.2018
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Year of Publication 29.03.2018
Patent
RG6076 (CD19-4-1BBL): CD19-Targeted 4-1BB Ligand Combination with Glofitamab As an Off-the-Shelf, Enhanced T-Cell Redirection Therapy for B-Cell Malignancies
Herter, Sylvia, Sam, Johannes, Ferrara Koller, Claudia, Diggelmann, Sarah, Bommer, Esther, Schönle, Anne, Claus, Christina, Bacac, Marina, Klein, Christian, Umana, Pablo
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Abstract 957: Design of CD19-4-1BBL, a novel CD19-targeted 4-1BB ligand for combination therapy with CD20 T-cell bispecific antibodies and CD20 antibodies
Xu, Wei, Sam, Johannes, Perro, Mario, Challier, John, Claus, Christina, Chen, Stanford, Koller, Claudia Ferrara, Mølhøj, Michael, Tournaviti, Stella, Bacac, Marina, Moore, Tom, Klein, Christian, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 1129: Monitoring intratumoral CD8 T cell infiltrates in human stem cell engrafted mice during single agent and combination immunotherapy with T cell bispecific antibodies using the human PET-tracer 89Zr-Df-IAB22M2C
Griessinger, Christoph M., Mascioni, Alessandro, Jia, Fang, Torgov, Michael, Nayak, Tapan, Mohan, Preethi Latha Bhavani, Nicolini, Valeria G., Sam, Johannes, Claus, Christina, Ferrara-Koller, Claudia, Bacac, Marina, Umana, Pablo, Wilson, Ian, Klein, Christian, Tessier, Jean J.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 6709: P329G-Engager: A novel universal antibody-based adaptor platform for cancer immunotherapy
Surowka, Marlena, Hutter-Karakoc, Idil, Darowski, Diana, Claus, Christina, Koller, Claudia Ferrara, Freimoser-Grundschober, Anne, Hofer, Thomas, Sobieniecki, Andrzej, Assisi, Denis, Leclair, Stephane, Moessner, Ekkehard, Umaña, Pablo, Amann, Maria, Klein, Christian
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Glycoengineered CD20 Antibody Obinutuzumab Activates Neutrophils and Mediates Phagocytosis Through CD16B More Efficiently Than Rituximab
Golay, Josée, Da Roit, Fabio, Bologna, Luca, Koller, Claudia Ferrara, Leusen, Jeanette H.W., Rambaldi, Alessandro, Klein, Christian, Introna, Martino
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article
4-1BBL TRIMER-CONTAINING ANTIGEN BINDING MOLECULES
Umana, Pablo, FERRARA KOLLER, Claudia, Klein, Christian, CLAUS, Christina
Year of Publication 23.03.2023
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Year of Publication 23.03.2023
Patent
HER2-targeting antigen binding molecules comprising 4-1BBL
Umana, Pablo, Junttila, Teemu Tapani, Claus, Christina, Ferrara Koller, Claudia, Klein, Christian
Year of Publication 20.08.2024
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Year of Publication 20.08.2024
Patent
NEW 4-1BBL TRIMER-CONTAINING ANTIGEN BINDING MOLECULES
KLEIN, Christian, FERRARA KOLLER, Claudia, UMAÑA, Pablo, CLAUS, Christina
Year of Publication 16.11.2022
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Year of Publication 16.11.2022
Patent
Therapeutic combination of 4-1 BB agonists with anti-CD20 antibodies
SAM, Johannes, XU, Wei, UMANA, Pablo, KLEIN, Christian, FERRARA KOLLER, Claudia
Year of Publication 20.06.2024
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Year of Publication 20.06.2024
Patent