The molecular basis of regulation of bacterial capsule assembly by Wzc
Yang, Yun, Liu, Jiwei, Clarke, Bradley R., Seidel, Laura, Bolla, Jani R., Ward, Philip N., Zhang, Peijun, Robinson, Carol V., Whitfield, Chris, Naismith, James H.
Published in Nature communications (16.07.2021)
Published in Nature communications (16.07.2021)
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Journal Article
Hypermucoviscosity Regulator RmpD Interacts with Wzc and Controls Capsular Polysaccharide Chain Length
Ovchinnikova, Olga G, Treat, Logan P, Teelucksingh, Tanisha, Clarke, Bradley R, Miner, Taryn A, Whitfield, Chris, Walker, Kimberly A, Miller, Virginia L
Published in mBio (27.06.2023)
Published in mBio (27.06.2023)
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Journal Article
A bifunctional O-antigen polymerase structure reveals a new glycosyltransferase family
Clarke, Bradley R., Ovchinnikova, Olga G., Sweeney, Ryan P., Kamski-Hennekam, Evelyn R., Gitalis, Russel, Mallette, Evan, Kelly, Steven D., Lowary, Todd L., Kimber, Matthew S., Whitfield, Chris
Published in Nature chemical biology (01.04.2020)
Published in Nature chemical biology (01.04.2020)
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Journal Article
Molecular basis for the structural diversity in serogroup O2-antigen polysaccharides in Klebsiella pneumoniae
Clarke, Bradley R., Ovchinnikova, Olga G., Kelly, Steven D., Williamson, Monica L., Butler, Jennifer E., Liu, Bin, Wang, Lu, Gou, Xi, Follador, Rainer, Lowary, Todd L., Whitfield, Chris
Published in The Journal of biological chemistry (30.03.2018)
Published in The Journal of biological chemistry (30.03.2018)
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Journal Article
A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide
Hagelueken, Gregor, Clarke, Bradley R, Huang, Hexian, Tuukkanen, Anne, Danciu, Iulia, Svergun, Dmitri I, Hussain, Rohanah, Liu, Huanting, Whitfield, Chris, Naismith, James H
Published in Nature structural & molecular biology (01.01.2015)
Published in Nature structural & molecular biology (01.01.2015)
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Journal Article
Lipopolysaccharide O antigen size distribution is determined by a chain extension complex of variable stoichiometry in Escherichia coli O9a
King, Jerry D, Berry, Scott, Clarke, Bradley R, Morris, Richard J, Whitfield, Chris
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2014)
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Journal Article
Inhibiting fatty acid synthesis overcomes colistin resistance
Carfrae, Lindsey A., Rachwalski, Kenneth, French, Shawn, Gordzevich, Rodion, Seidel, Laura, Tsai, Caressa N., Tu, Megan M., MacNair, Craig R., Ovchinnikova, Olga G., Clarke, Bradley R., Whitfield, Chris, Brown, Eric D.
Published in Nature microbiology (01.06.2023)
Published in Nature microbiology (01.06.2023)
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Journal Article
The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase, Wzz, from enterobacterial common antigen biosynthesis form a complex
Weckener, Miriam, Woodward, Laura S, Clarke, Bradley R, Liu, Huanting, Ward, Philip N, Le Bas, Audrey, Bhella, David, Whitfield, Chris, Naismith, James H
Published in Open biology (22.03.2023)
Published in Open biology (22.03.2023)
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Journal Article
3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli
Collins, Richard F, Beis, Konstantinos, Dong, Changjiang, Botting, Catherine H, McDonnell, Catherine, Ford, Robert C, Clarke, Bradley R, Whitfield, Chris, Naismith, James H
Published in Proceedings of the National Academy of Sciences - PNAS (13.02.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (13.02.2007)
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Journal Article
Coordination of Polymerization, Chain Termination, and Export in Assembly of the Escherichia coli Lipopolysaccharide O9a Antigen in an ATP-binding Cassette Transporter-dependent Pathway
Clarke, Bradley R., Greenfield, Laura K., Bouwman, Catrien, Whitfield, Chris
Published in The Journal of biological chemistry (30.10.2009)
Published in The Journal of biological chemistry (30.10.2009)
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Journal Article
Substrate Specificity of Bacterial Oligosaccharyltransferase Suggests a Common Transfer Mechanism for the Bacterial and Eukaryotic Systems
Wacker, Michael, Feldman, Mario F., Callewaert, Nico, Kowarik, Michael, Clarke, Bradley R., Pohl, Nicola L., Hernandez, Marcela, Vines, Enrique D., Valvano, Miguel A., Whitfield, Chris, Aebi, Markus
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (02.05.2006)
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Journal Article
Nonreducing Terminal Modifications Determine the Chain Length of Polymannose O Antigens of Escherichia coli and Couple Chain Termination to Polymer Export via an ATP-binding Cassette Transporter
Clarke, Bradley R, Cuthbertson, Leslie, Whitfield, Chris
Published in The Journal of biological chemistry (20.08.2004)
Published in The Journal of biological chemistry (20.08.2004)
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Journal Article
Periplasmic Protein-Protein Contacts in the Inner Membrane Protein Wzc Form a Tetrameric Complex Required for the Assembly of Escherichia coli Group 1 Capsules
Collins, Richard F., Beis, Konstantinos, Clarke, Bradley R., Ford, Robert C., Hulley, Martyn, Naismith, James H., Whitfield, Chris
Published in The Journal of biological chemistry (27.01.2006)
Published in The Journal of biological chemistry (27.01.2006)
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Journal Article
The Klebsiella pneumoniae O12 ATP-binding Cassette (ABC) Transporter Recognizes the Terminal Residue of Its O-antigen Polysaccharide Substrate
Mann, Evan, Mallette, Evan, Clarke, Bradley R., Kimber, Matthew S., Whitfield, Chris
Published in The Journal of biological chemistry (29.04.2016)
Published in The Journal of biological chemistry (29.04.2016)
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Journal Article
Klebsiella pneumoniae O1 and O2ac antigens provide prototypes for an unusual strategy for polysaccharide antigen diversification
Kelly, Steven D., Clarke, Bradley R., Ovchinnikova, Olga G., Sweeney, Ryan P., Williamson, Monica L., Lowary, Todd L., Whitfield, Chris
Published in The Journal of biological chemistry (12.07.2019)
Published in The Journal of biological chemistry (12.07.2019)
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Journal Article
Substrate recognition by a carbohydrate-binding module in the prototypical ABC transporter for lipopolysaccharide O-antigen from Escherichia coli O9a
Mann, Evan, Kelly, Steven D., Al-Abdul-Wahid, M. Sameer, Clarke, Bradley R., Ovchinnikova, Olga G., Liu, Bin, Whitfield, Chris
Published in The Journal of biological chemistry (11.10.2019)
Published in The Journal of biological chemistry (11.10.2019)
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Journal Article
Structure of WbdD: a bifunctional kinase and methyltransferase that regulates the chain length of the O antigen in Escherichia coli O9a
Hagelueken, Gregor, Huang, Hexian, Clarke, Bradley R., Lebl, Tomas, Whitfield, Chris, Naismith, James H.
Published in Molecular microbiology (01.11.2012)
Published in Molecular microbiology (01.11.2012)
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