Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator
Hao, Junliang, Dehlinger, Veronique, Fivush, Adam M., Rudyk, Helene C.E., Britton, Thomas C., Hollinshead, Sean P., Vokits, Benjamin P., Clark, Barry P., Henry, Steven S., Massey, Steven M., Peng, Langu, Dressman, Bruce A., Heinz, Beverly A., Roberts, Edda F., Bracey-Walker, Mallorie R., Swanson, Steven, Catlow, John T., Love, Patrick L., Tepool, Anita D., Peters, Steven C., Simmons, Rosa Maria A., Iyengar, Smriti, McKinzie, David L., Monn, James A.
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
Published in Bioorganic & medicinal chemistry letters (01.03.2013)
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The extraordinary reactions of phenyldimethylsilyllithium with N,N-disubstituted amides
Buswell, M, Fleming, Ghosh, U, Mack, S, Russell, M, Clark, BP
Published in Organic & biomolecular chemistry (21.10.2004)
Published in Organic & biomolecular chemistry (21.10.2004)
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Discovery and structure–activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors
Boot, John, Cases, Manuel, Clark, Barry P., Findlay, Jeremy, Gallagher, Peter T., Hayhurst, Lorna, Man, Teresa, Montalbetti, Christian, Rathmell, Richard E., Rudyk, Hélène, Walter, Magnus W., Whatton, Maria, Wood, Virginia
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists
Kingston, Ann E, Griffey, Kelly, Johnson, Michael P, Chamberlain, Mary-Jo, Kelly, Gerald, Tomlinson, Rosemarie, Wright, Rebecca A, Johnson, Bryan G, Schoepp, Darryle D, Harris, John R, Clark, Barry P, Baker, Richard S, Tizzano, Joseph P
Published in Neuroscience letters (20.09.2002)
Published in Neuroscience letters (20.09.2002)
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Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals
Miller, Jacqueline C, Howson, Patrick A, Conway, Stuart J, Williams, Richard V, Clark, Barry P, Jane, David E
Published in British journal of pharmacology (01.08.2003)
Published in British journal of pharmacology (01.08.2003)
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Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors
Conway, Stuart J, Miller, Jacqueline C, Howson, Patrick A, Clark, Barry P, Jane, David E
Published in Bioorganic & medicinal chemistry letters (26.03.2001)
Published in Bioorganic & medicinal chemistry letters (26.03.2001)
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α-Amino esters as nucleophiles in diastereoselective palladium catalysed allylic substitution reactions
Humphries, Mark E, Clark, Barry P, Williams, Jonathan M.J
Published in Tetrahedron: asymmetry (13.03.1998)
Published in Tetrahedron: asymmetry (13.03.1998)
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The role of type 1 metabotropic glutamate receptors in the generation of dorsal root reflexes induced by acute arthritis or the spinal infusion of 4-aminopyridine in the anesthetized rat
Zhang, Li Ping, Chen, Ying, Clark, Barry P., Sher, Emanuele, Westlund High, Karin N.
Published in The journal of pain (2000)
Published in The journal of pain (2000)
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Synthesis of the anti-trypanosomal agent (±)-hydroxyanthecotulide by Cr(ii)-catalysed allylation and Meyer-Schuster rearrangementElectronic Supplementary Information (ESI) available: Experimental procedures and spectroscopic data along with 1H and 13C NMR spectra for all compounds synthesised. See DOI: 10.1039/c2cc32283hDedicated to Professor Philip J. Parsons on the occasion of his 60th birthday
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New multi-bridged cryptands: Polyazamacrocyclic schiff bases formed in a tetrapode capping reaction
Clark, Barry P, Harris, John R, Timms, Graham H, Olkowski, Jennifer L
Published in Tetrahedron letters (29.05.1995)
Published in Tetrahedron letters (29.05.1995)
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Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4
Conway, SJ, Miller, JC, Bond, AD, Clark, BP, Jane, DE
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (21.07.2002)
Published in Perkin 1 : an international journal of organic and bio-organic chemistry (21.07.2002)
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