Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility
Gordhan, Heeren M., Miller, Steven T., Clancy, Daphne C., Ina, Maria, McDougal, Alan V., Cutno, D’Quan K., Brown, Robert V., Lichorowic, Cynthia L., Sturdivant, Jill M., Vick, Kyle A., Williams, Stuart S., deLong, Mitchell A., White, Jeffrey C., Kopczynski, Casey C., Ellis, David A.
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
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Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy
Thomson, Stephen A., Banker, Pierette, Bickett, D. Mark, Boucheron, Joyce A., Carter, H. Luke, Clancy, Daphne C., Cooper, Joel P., Dickerson, Scott H., Garrido, Dulce M., Nolte, Robert T., Peat, Andrew J., Sheckler, Lauren R., Sparks, Steven M., Tavares, Francis X., Wang, Liping, Wang, Tony Y., Weiel, James E.
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
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Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues
Sparks, Steven M., Banker, Pierette, Bickett, David M., Clancy, Daphne C., Dickerson, Scott H., Garrido, Dulce M., Golden, Pamela L., Peat, Andrew J., Sheckler, Lauren R., Tavares, Francis X., Thomson, Stephen A., Weiel, James E.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article
Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors
Evans, Karen A., Li, Yue H., Coppo, Frank T., Graybill, Todd L., Cichy-Knight, Maria, Patel, Mehul, Gale, Jennifer, Li, Hu, Thrall, Sara H., Tew, David, Tavares, Francis, Thomson, Stephen A., Weiel, James E., Boucheron, Joyce A., Clancy, Daphne C., Epperly, Andrea H., Golden, Pamela L.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Journal Article
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups
Sparks, Steven M., Banker, Pierette, Bickett, David M., Carter, H. Luke, Clancy, Daphne C., Dickerson, Scott H., Dwornik, Kate A., Garrido, Dulce M., Golden, Pamela L., Nolte, Robert T., Peat, Andrew J., Sheckler, Lauren R., Tavares, Francis X., Thomson, Stephen A., Wang, Liping, Weiel, James E.
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
Published in Bioorganic & medicinal chemistry letters (01.02.2009)
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Journal Article