Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion
Dayeh, Tasnim, Volkov, Petr, Salö, Sofia, Hall, Elin, Nilsson, Emma, Olsson, Anders H, Kirkpatrick, Clare L, Wollheim, Claes B, Eliasson, Lena, Rönn, Tina, Bacos, Karl, Ling, Charlotte
Published in PLoS genetics (01.03.2014)
Published in PLoS genetics (01.03.2014)
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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
Fadista, João, Vikman, Petter, Laakso, Emilia Ottosson, Mollet, Inês Guerra, Esguerra, Jonathan Lou, Taneera, Jalal, Storm, Petter, Osmark, Peter, Ladenvall, Claes, Prasad, Rashmi B., Hansson, Karin B., Finotello, Francesca, Uvebrant, Kristina, Ofori, Jones K., Di Camillo, Barbara, Krus, Ulrika, Cilio, Corrado M., Hansson, Ola, Eliasson, Lena, Rosengren, Anders H., Renström, Erik, Wollheim, Claes B., Groop, Leif
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2014)
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Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity
Nguyen, Ha Thu, Wiederkehr, Andreas, Wollheim, Claes B., Park, Kyu-Sang
Published in Experimental & molecular medicine (01.02.2024)
Published in Experimental & molecular medicine (01.02.2024)
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A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets
Taneera, Jalal, Lang, Stefan, Sharma, Amitabh, Fadista, Joao, Zhou, Yuedan, Ahlqvist, Emma, Jonsson, Anna, Lyssenko, Valeriya, Vikman, Petter, Hansson, Ola, Parikh, Hemang, Korsgren, Olle, Soni, Arvind, Krus, Ulrika, Zhang, Enming, Jing, Xing-Jun, Esguerra, Jonathan L.S., Wollheim, Claes B., Salehi, Albert, Rosengren, Anders, Renström, Erik, Groop, Leif
Published in Cell metabolism (03.07.2012)
Published in Cell metabolism (03.07.2012)
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Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell
Ofori, Jones K., Salunkhe, Vishal A., Bagge, Annika, Vishnu, Neelanjan, Nagao, Mototsugu, Mulder, Hindrik, Wollheim, Claes B., Eliasson, Lena, Esguerra, Jonathan L. S.
Published in Scientific reports (23.03.2017)
Published in Scientific reports (23.03.2017)
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Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
Chareyron, Isabelle, Christen, Stefan, Moco, Sofia, Valsesia, Armand, Lassueur, Steve, Dayon, Loïc, Wollheim, Claes B., Santo Domingo, Jaime, Wiederkehr, Andreas
Published in Diabetologia (01.12.2020)
Published in Diabetologia (01.12.2020)
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Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion
Wiederkehr, Andreas, Szanda, Gergő, Akhmedov, Dmitry, Mataki, Chikage, Heizmann, Claus W., Schoonjans, Kristina, Pozzan, Tullio, Spät, András, Wollheim, Claes B.
Published in Cell metabolism (04.05.2011)
Published in Cell metabolism (04.05.2011)
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Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors
Aslanoglou, Despoina, Bertera, Suzanne, Sánchez-Soto, Marta, Benjamin Free, R., Lee, Jeongkyung, Zong, Wei, Xue, Xiangning, Shrestha, Shristi, Brissova, Marcela, Logan, Ryan W., Wollheim, Claes B., Trucco, Massimo, Yechoor, Vijay K., Sibley, David R., Bottino, Rita, Freyberg, Zachary
Published in Translational psychiatry (16.02.2021)
Published in Translational psychiatry (16.02.2021)
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Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes
Mahdi, Taman, Hänzelmann, Sonja, Salehi, Albert, Muhammed, Sarheed J., Reinbothe, Thomas M., Tang, Yunzhao, Axelsson, Annika S., Zhou, Yuedan, Jing, Xingjun, Almgren, Peter, Krus, Ulrika, Taneera, Jalal, Blom, Anna M., Lyssenko, Valeriya, Esguerra, Jonathan Lou S., Hansson, Ola, Eliasson, Lena, Derry, Jonathan, Zhang, Enming, Wollheim, Claes B., Groop, Leif, Renström, Erik, Rosengren, Anders H.
Published in Cell metabolism (07.11.2012)
Published in Cell metabolism (07.11.2012)
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Essential Role of Mitochondrial Ca2+ Uniporter in the Generation of Mitochondrial pH Gradient and Metabolism-Secretion Coupling in Insulin-releasing Cells
Quan, Xianglan, Nguyen, Tuyet Thi, Choi, Seong-Kyung, Xu, Shanhua, Das, Ranjan, Cha, Seung-Kuy, Kim, Nari, Han, Jin, Wiederkehr, Andreas, Wollheim, Claes B., Park, Kyu-Sang
Published in The Journal of biological chemistry (13.02.2015)
Published in The Journal of biological chemistry (13.02.2015)
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Synaptotagmins bind calcium to release insulin
Gauthier, Benoit R, Wollheim, Claes B
Published in American journal of physiology: endocrinology and metabolism (01.12.2008)
Published in American journal of physiology: endocrinology and metabolism (01.12.2008)
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Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells
Nguyen, Tuyet Thi, Quan, Xianglan, Hwang, Kyu-Hee, Xu, Shanhua, Das, Ranjan, Choi, Seong-Kyung, Wiederkehr, Andreas, Wollheim, Claes B, Cha, Seung-Kuy, Park, Kyu-Sang
Published in American journal of physiology: endocrinology and metabolism (01.06.2015)
Published in American journal of physiology: endocrinology and metabolism (01.06.2015)
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Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase
Andersson, Lotta E, Shcherbina, Liliya, Al-Majdoub, Mahmoud, Vishnu, Neelanjan, Arroyo, Claudia Balderas, Aste Carrara, Jonathan, Wollheim, Claes B, Fex, Malin, Mulder, Hindrik, Wierup, Nils, Spégel, Peter
Published in Diabetes (New York, N.Y.) (01.03.2018)
Published in Diabetes (New York, N.Y.) (01.03.2018)
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Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells
Merglen, Arnaud, Theander, Sten, Rubi, Blanca, Chaffard, Gaelle, Wollheim, Claes B, Maechler, Pierre
Published in Endocrinology (Philadelphia) (01.02.2004)
Published in Endocrinology (Philadelphia) (01.02.2004)
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Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane
Mohammad Al-Amily, Israa, Sjögren, Marie, Duner, Pontus, Tariq, Mohammad, Wollheim, Claes B, Salehi, Albert
Published in Biomolecules (Basel, Switzerland) (01.03.2023)
Published in Biomolecules (Basel, Switzerland) (01.03.2023)
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Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release
Spégel, Peter, Sharoyko, Vladimir V, Goehring, Isabel, Danielsson, Anders P H, Malmgren, Siri, Nagorny, Cecilia L F, Andersson, Lotta E, Koeck, Thomas, Sharp, Geoffrey W G, Straub, Susanne G, Wollheim, Claes B, Mulder, Hindrik
Published in Biochemical journal (15.03.2013)
Published in Biochemical journal (15.03.2013)
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Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release
RAVIER, Magalie A, GÜLDENAGEL, Martin, CHAROLLAIS, Anne, GJINOVCI, Asllan, CAILLE, Dorothée, SÖHL, Goran, WOLLHEIM, Claes B, WILLECKE, Klaus, HENQUIN, Jean-Claude, MEDA, Paolo
Published in Diabetes (New York, N.Y.) (01.06.2005)
Published in Diabetes (New York, N.Y.) (01.06.2005)
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