HIV-1 Escape from a Small Molecule, CCR5-Specific Entry Inhibitor Does Not Involve CXCR4 Use
Trkola, Alexandra, Kuhmann, Shawn E., Strizki, Julie M., Maxwell, Elizabeth, Ketas, Tom, Morgan, Tom, Pugach, Pavel, Xu, Serena, Wojcik, Lisa, Tagat, Jayaram, Palani, Anandan, Shapiro, Sherry, Clader, John W., McCombie, Stuart, Reyes, Gregory R., Baroudy, Bahige M., Moore, John P.
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2002)
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Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry
Tsamis, Fotini, Gavrilov, Svetlana, Kajumo, Francis, Seibert, Christoph, Kuhmann, Shawn, Ketas, Tom, Trkola, Alexandra, Palani, Anadan, Clader, John W, Tagat, Jayaram R, McCombie, Stuart, Baroudy, Bahige, Moore, John P, Sakmar, Thomas P, Dragic, Tatjana
Published in Journal of Virology (01.05.2003)
Published in Journal of Virology (01.05.2003)
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SCH-C (SCH 351125), An Orally Bioavailable, Small Molecule Antagonist of the Chemokine Receptor CCR5, is a Potent Inhibitor of HIV-1 Infection in vitro and in vivo
Strizki, Julie M., Xu, Serena, Wagner, Nicole E., Wojcik, Lisa, Liu, Jia, Hou, Yan, Endres, Michael, Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Tagat, Jayaram R., McCombie, Stuart, Cox, Kathleen, Fawzi, Ahmad B., Chou, Chuan-Chu, Pugliese-Sivo, Catherine, Davies, Liza, Moreno, Mary E., Ho, David D., Trkola, Alexandra, Stoddart, Cheryl A., Moore, John P., Reyes, Gregory R., Baroudy, Bahige M.
Published in Proceedings of the National Academy of Sciences - PNAS (23.10.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (23.10.2001)
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Discovery of 4-[(Z)-(4-bromophenyl)-(ethoxyimino)methyll-1 '-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4 '-methyl-1,4 '-bipiperidine N-oxide (SCH 351125): An orally bioavailable human CCR5 antagonist for the treatment of HIV infection
Palani, A, Shapiro, S, Clader, JW, Greenlee, WJ, Cox, K, Strizki, J, Endres, M, Baroudy, BM
Published in Journal of medicinal chemistry (11.10.2001)
Published in Journal of medicinal chemistry (11.10.2001)
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Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas
McBriar, Mark D, Guzik, Henry, Shapiro, Sherry, Paruchova, Jaroslava, Xu, Ruo, Palani, Anandan, Clader, John W, Cox, Kathleen, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian D, Weig, Blair, Weston, Daniel J, Farley, Constance, Cook, John
Published in Journal of medicinal chemistry (06.04.2006)
Published in Journal of medicinal chemistry (06.04.2006)
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Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists: Orally Efficacious Antiobesity Therapeutics
McBriar, Mark D, Guzik, Henry, Xu, Ruo, Paruchova, Jaroslava, Li, Shengjian, Palani, Anandan, Clader, John W, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian, Weig, Blair
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
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Biaryl Ureas as Potent and Orally Efficacious Melanin Concentrating Hormone Receptor 1 Antagonists for the Treatment of Obesity
Palani, Anandan, Shapiro, Sherry, McBriar, Mark D, Clader, John W, Greenlee, William J, Spar, Brian, Kowalski, Timothy J, Farley, Constance, Cook, John, van Heek, Margaret, Weig, Blair, O'Neill, Kim, Graziano, Michael, Hawes, Brian
Published in Journal of medicinal chemistry (28.07.2005)
Published in Journal of medicinal chemistry (28.07.2005)
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Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity
Palani, Anandan, Shapiro, Sherry, Josien, Hubert, Bara, Thomas, Clader, John W, Greenlee, William J, Cox, Kathleen, Strizki, Julie M, Baroudy, Bahige M
Published in Journal of medicinal chemistry (04.07.2002)
Published in Journal of medicinal chemistry (04.07.2002)
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Design and synthesis of piperidinyl piperidine analogues as potent and selective M 2 muscarinic receptor antagonists
Wang, Yuguang, Chackalamannil, Samuel, Hu, Zhiyong, Clader, John W, Greenlee, William, Billard, William, Binch, Herbert, Crosby, Gordon, Ruperto, Vilma, Duffy, Ruth A, McQuade, Robert, Lachowicz, Jean E
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists
Xu, Ruo, Li, Shengjian, Paruchova, Jaroslava, McBriar, Mark D., Guzik, Henry, Palani, Anandan, Clader, John W., Cox, Kathleen, Greenlee, William J., Hawes, Brian E., Kowalski, Timothy J., O’Neill, Kim, Spar, Brian D., Weig, Blair, Weston, Daniel J.
Published in Bioorganic & medicinal chemistry (15.05.2006)
Published in Bioorganic & medicinal chemistry (15.05.2006)
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Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption
Rosenblum, Stuart B, Huynh, Tram, Afonso, Adriano, Davis, Harry R, Yumibe, Nathan, Clader, John W, Burnett, Duane A
Published in Journal of medicinal chemistry (12.03.1998)
Published in Journal of medicinal chemistry (12.03.1998)
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Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides
Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Vice, Susan, McCombie, Stuart, Cox, Kathleen, Strizki, Julie, Baroudy, Bahige M.
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
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2-Azetidinones as Inhibitors of Cholesterol Absorption
Burnett, Duane A, Caplen, Mary Ann, Davis, Harry R, Burrier, Robert E, Clader, John W
Published in Journal of medicinal chemistry (01.06.1994)
Published in Journal of medicinal chemistry (01.06.1994)
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Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED
Boyle, Craig D., Xu, Ruo, Asberom, Theodros, Chackalamannil, Samuel, Clader, John W., Greenlee, William J., Guzik, Henry, Hu, Yuequing, Hu, Zhiyong, Lankin, Claire M., Pissarnitski, Dmitri A., Stamford, Andrew W., Wang, Yuguang, Skell, Jeffrey, Kurowski, Stanley, Vemulapalli, Subbarao, Palamanda, Jairam, Chintala, Madhu, Wu, Ping, Myers, Joyce, Wang, Peng
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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Journal Article
Biological evaluation and interconversion studies of rotamers of SCH 351125, an orally bioavailable CCR5 antagonist
Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Blythin, David, Cox, Kathleen, Wagner, Nicole E., Strizki, Julie, Baroudy, Bahige M., Dan, Niya
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
Published in Bioorganic & medicinal chemistry letters (24.02.2003)
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Journal Article
SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction
PISSARNITSKI, Dmitri A, ASBEROM, Theodros, PALAMANDA, Jairam, STAMFORD, Andrew W, VEMULAPALLI, Subbarao, YUGUANG WANG, PENG WANG, PING WU, RUO XU, BOYLE, Craig D, CHACKALAMANNIL, Samuel, CHINTALA, Madhu, CLADER, John W, GREENLEE, William J, YUEQING HU, KUROWSKI, Stanley, MYERS, Joyce
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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