Discovery of 4-[(Z)-(4-Bromophenyl)- (ethoxyimino)methyl]-1‘-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4‘-methyl-1,4‘- bipiperidine N-Oxide (SCH 351125): An Orally Bioavailable Human CCR5 Antagonist for the Treatment of HIV Infection
Palani, Anandan, Shapiro, Sherry, Clader, John W, Greenlee, William J, Cox, Kathleen, Strizki, Julie, Endres, Michael, Baroudy, Bahige M
Published in Journal of medicinal chemistry (11.10.2001)
Published in Journal of medicinal chemistry (11.10.2001)
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HIV-1 Escape from a Small Molecule, CCR5-Specific Entry Inhibitor Does Not Involve CXCR4 Use
Trkola, Alexandra, Kuhmann, Shawn E., Strizki, Julie M., Maxwell, Elizabeth, Ketas, Tom, Morgan, Tom, Pugach, Pavel, Xu, Serena, Wojcik, Lisa, Tagat, Jayaram, Palani, Anandan, Shapiro, Sherry, Clader, John W., McCombie, Stuart, Reyes, Gregory R., Baroudy, Bahige M., Moore, John P.
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (08.01.2002)
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Discovery of 1-(4-Fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)- hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235): A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption
Rosenblum, Stuart B, Huynh, Tram, Afonso, Adriano, Davis, Harry R, Yumibe, Nathan, Clader, John W, Burnett, Duane A
Published in Journal of medicinal chemistry (12.03.1998)
Published in Journal of medicinal chemistry (12.03.1998)
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Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry
Tsamis, Fotini, Gavrilov, Svetlana, Kajumo, Francis, Seibert, Christoph, Kuhmann, Shawn, Ketas, Tom, Trkola, Alexandra, Palani, Anadan, Clader, John W, Tagat, Jayaram R, McCombie, Stuart, Baroudy, Bahige, Moore, John P, Sakmar, Thomas P, Dragic, Tatjana
Published in Journal of Virology (01.05.2003)
Published in Journal of Virology (01.05.2003)
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SCH-C (SCH 351125), An Orally Bioavailable, Small Molecule Antagonist of the Chemokine Receptor CCR5, is a Potent Inhibitor of HIV-1 Infection in vitro and in vivo
Strizki, Julie M., Xu, Serena, Wagner, Nicole E., Wojcik, Lisa, Liu, Jia, Hou, Yan, Endres, Michael, Palani, Anandan, Shapiro, Sherry, Clader, John W., Greenlee, William J., Tagat, Jayaram R., McCombie, Stuart, Cox, Kathleen, Fawzi, Ahmad B., Chou, Chuan-Chu, Pugliese-Sivo, Catherine, Davies, Liza, Moreno, Mary E., Ho, David D., Trkola, Alexandra, Stoddart, Cheryl A., Moore, John P., Reyes, Gregory R., Baroudy, Bahige M.
Published in Proceedings of the National Academy of Sciences - PNAS (23.10.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (23.10.2001)
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2-Azetidinones as Inhibitors of Cholesterol Absorption
Burnett, Duane A, Caplen, Mary Ann, Davis, Harry R, Burrier, Robert E, Clader, John W
Published in Journal of medicinal chemistry (01.06.1994)
Published in Journal of medicinal chemistry (01.06.1994)
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Discovery of Orally Efficacious Melanin-Concentrating Hormone Receptor-1 Antagonists as Antiobesity Agents. Synthesis, SAR, and Biological Evaluation of Bicyclo[3.1.0]hexyl Ureas
McBriar, Mark D, Guzik, Henry, Shapiro, Sherry, Paruchova, Jaroslava, Xu, Ruo, Palani, Anandan, Clader, John W, Cox, Kathleen, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian D, Weig, Blair, Weston, Daniel J, Farley, Constance, Cook, John
Published in Journal of medicinal chemistry (06.04.2006)
Published in Journal of medicinal chemistry (06.04.2006)
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Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists: Orally Efficacious Antiobesity Therapeutics
McBriar, Mark D, Guzik, Henry, Xu, Ruo, Paruchova, Jaroslava, Li, Shengjian, Palani, Anandan, Clader, John W, Greenlee, William J, Hawes, Brian E, Kowalski, Timothy J, O'Neill, Kim, Spar, Brian, Weig, Blair
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
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Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity
Palani, Anandan, Shapiro, Sherry, Josien, Hubert, Bara, Thomas, Clader, John W, Greenlee, William J, Cox, Kathleen, Strizki, Julie M, Baroudy, Bahige M
Published in Journal of medicinal chemistry (04.07.2002)
Published in Journal of medicinal chemistry (04.07.2002)
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Synthesis of C3 Heteroatom-Substituted Azetidinones That Display Potent Cholesterol Absorption Inhibitory Activity
McKittrick, Brian A, Ma, Ke, Huie, Keith, Yumibe, Nathan, Davis, Harry, Clader, John W, Czarniecki, Michael, McPhail, Andrew T
Published in Journal of medicinal chemistry (26.02.1998)
Published in Journal of medicinal chemistry (26.02.1998)
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Muscarinic agonists and antagonists in the treatment of Alzheimer's disease
Greenlee, W, Clader, J, Asberom, T, McCombie, S, Ford, J, Guzik, H, Kozlowski, J, Li, S, Liu, C, Lowe, D, Vice, S, Zhao, H, Zhou, G, Billard, W, Binch, H, Crosby, R, Duffy, R, Lachowicz, J, Coffin, V, Watkins, R, Ruperto, V, Strader, C, Taylor, L, Cox, K
Published in Farmaco (Società chimica italiana : 1989) (01.04.2001)
Published in Farmaco (Società chimica italiana : 1989) (01.04.2001)
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Substituted (1,2-Diarylethyl)amide Acyl-CoA:Cholesterol Acyltransferase Inhibitors: Effect of Polar Groups on in Vitro and in Vivo Activity
Clader, John W, Berger, Joel G, Burrier, Robert E, Davis, Harry R, Domalski, Martin, Dugar, Sundeep, Kogan, Timothy P, Salisbury, Brian, Vaccaro, Wayne
Published in Journal of medicinal chemistry (01.05.1995)
Published in Journal of medicinal chemistry (01.05.1995)
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Synthesis and receptor affinities of some conformationally restricted analogs of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol
Berger, Joel G, Chang, Wei K, Clader, John W, Hou, Donald, Chipkin, Richard E, McPhail, Andrew T
Published in Journal of medicinal chemistry (01.08.1989)
Published in Journal of medicinal chemistry (01.08.1989)
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Supracondylar humeral osteotomy for traumatic childhood cubitus varus deformity
Oppenheim, W L, Clader, T J, Smith, C, Bayer, M
Published in Clinical orthopaedics and related research (01.09.1984)
Published in Clinical orthopaedics and related research (01.09.1984)
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Synthesis of an optically pure 3-unsubstituted β-lactam using an asymmetric Reformatsky reaction and its conversion to cholesterol absorption inhibitors
Shankar, B.B., Kirkup, M.P., McCombie, S.W., Clader, J.W., Ganguly, A.K.
Published in Tetrahedron letters (10.06.1996)
Published in Tetrahedron letters (10.06.1996)
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Interaction of small molecule inhibitors of HIV-1 entry with CCR5
Seibert, Christoph, Ying, Weiwen, Gavrilov, Svetlana, Tsamis, Fotini, Kuhmann, Shawn E., Palani, Anandan, Tagat, Jayaram R., Clader, John W., McCombie, Stuart W., Baroudy, Bahige M., Smith, Steven O., Dragic, Tatjana, Moore, John P., Sakmar, Thomas P.
Published in Virology (New York, N.Y.) (25.05.2006)
Published in Virology (New York, N.Y.) (25.05.2006)
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Identification and characterization of an acyl-CoA:triterpene acyltransferase activity in rabbit and human tissues
Tabas, I, Beatini, N, Chen, LL, Su, WC, Puar, MS, Dugar, S, Clader, JW
Published in Journal of lipid research (01.10.1991)
Published in Journal of lipid research (01.10.1991)
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