The first potent inhibitor of squalene synthase: a profound contribution of an ether oxygen to inhibitor-enzyme interaction
Biller, Scott A, Sofia, Michael J, DeLange, Barbara, Forster, Cornelia, Gordon, Eric M, Harrity, Thomas, Rich, Lois C, Ciosek, Carl P
Published in Journal of the American Chemical Society (01.10.1991)
Published in Journal of the American Chemical Society (01.10.1991)
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Journal Article
Orally Active Squalene Synthase Inhibitors: Bis((acyloxy)alkyl) Prodrugs of the α-Phosphonosulfonic Acid Moiety
Dickson, John K, Biller, Scott A, Magnin, David R, Petrillo, Edward W, Hillyer, John W, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Gregg, Richard E, Harrity, Thomas W, Jolibois, Kern G, Kalinowski, Stephen S, Kunselman, Lori K, Mookhtiar, Kasim A, Ciosek, Carl P
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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Journal Article
Enantioselective Synthesis of α-Phosphono Sulfonate Squalene Synthase Inhibitors: Chiral Recognition in the Interactions of an α-Phosphono Sulfonate Inhibitor with Squalene Synthase
Lawrence, R. Michael, Biller, Scott A, Dickson, John K, Logan, Janette V. H, Magnin, David R, Sulsky, Richard B, DiMarco, John D, Gougoutas, Jack Z, Beyer, Barbara D, Taylor, Susan C, Lan, Shih-Jung, Ciosek, Carl P, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Slusarchyk, Dorothy A
Published in Journal of the American Chemical Society (20.11.1996)
Published in Journal of the American Chemical Society (20.11.1996)
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Journal Article
1,1-Bisphosphonate Squalene Synthase Inhibitors: Interplay Between the Isoprenoid Subunit and the Diphosphate Surrogate
Magnin, David R, Dickson, John K, Logan, Janette V, Lawrence, R. Michael, Chen, Ying, Sulsky, Richard B, Ciosek, Carl P, Biller, Scott A, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A
Published in Journal of medicinal chemistry (01.07.1995)
Published in Journal of medicinal chemistry (01.07.1995)
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Journal Article
Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase
Biller, Scott A, Forster, Cornelia, Gordon, Eric M, Harrity, Thomas, Scott, William A, Ciosek, Carl P
Published in Journal of medicinal chemistry (01.10.1988)
Published in Journal of medicinal chemistry (01.10.1988)
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Journal Article
Isoprenyl phosphinylformates: new inhibitors of squalene synthetase
Biller, Scott A, Forster, Cornelia, Gordon, Eric M, Harrity, Thomas, Rich, Lois C, Marretta, Joseph, Ciosek, Carl P
Published in Journal of medicinal chemistry (01.06.1991)
Published in Journal of medicinal chemistry (01.06.1991)
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Journal Article
Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety
Robl, Jeffrey A, Duncan, Laurelee A, Pluscec, Jelka, Karanewsky, Donald S, Gordon, Eric M, Ciosek, Carl P, Rich, Lois C, Dehmel, Viviane C, Slusarchyk, Dorothy A
Published in Journal of medicinal chemistry (01.09.1991)
Published in Journal of medicinal chemistry (01.09.1991)
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Journal Article
Phosphorus-containing inhibitors of HMG-CoA reductase. I. 4-[(2-Arylethyl)hydroxyphosphinyl]-3-hydroxybutanoic acids: a new class of cell selective inhibitors of cholesterol biosynthesis
Karanewsky, Donald S, Badia, Michael C, Ciosek, Carl P, Robl, Jeffrey A, Sofia, Michael J, Simpkins, Ligaya M, DeLange, Barbara, Harrity, Thomas W, Biller, Scott A, Gordon, Eric M
Published in Journal of medicinal chemistry (01.11.1990)
Published in Journal of medicinal chemistry (01.11.1990)
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Journal Article
An Inhibitor of the Microsomal Triglyceride Transfer Protein Inhibits apoB Secretion from HepG2 Cells
Jamil, Haris, Gordon, David A., Eustice, David C., Brooks, Cindy M., Dickson, John K., Chen, Ying, Ricci, Beverly, Chu, Ching-Hsuen, Harrity, Thomas W., Ciosek, Carl P., Biller, Scott A., Gregg, Richard E., Wetterau, John R.
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.1996)
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Journal Article
Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo
Ciosek, C P, Magnin, D R, Harrity, T W, Logan, J V, Dickson, J K, Gordon, E M, Hamilton, K A, Jolibois, K G, Kunselman, L K, Lawrence, R M
Published in The Journal of biological chemistry (25.11.1993)
Published in The Journal of biological chemistry (25.11.1993)
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Journal Article
α-Phosphonosulfonic Acids: Potent and Selective Inhibitors of Squalene Synthase
Magnin, David R, Biller, Scott A, Chen, Ying, Dickson, John K, Fryszman, Olga M, Lawrence, R. Michael, Logan, Janette V. H, Sieber-McMaster, Ellen S, Sulsky, Richard B, Traeger, Sarah C, Hsieh, Dolly C, Lan, Shih-Jung, Rinehart, J. Kent, Harrity, Thomas W, Jolibois, Kern G, Kunselman, Lori K, Rich, Lois C, Slusarchyk, Dorothy A, Ciosek, Carl P
Published in Journal of medicinal chemistry (02.02.1996)
Published in Journal of medicinal chemistry (02.02.1996)
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Journal Article
Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis
Karanewsky, D S, Badia, M C, Ciosek, Jr, C P, Robl, J A, Sofia, M J, Simpkins, L M, DeLange, B, Harrity, T W, Biller, S A, Gordon, E M
Published in Journal of medicinal chemistry (01.11.1990)
Published in Journal of medicinal chemistry (01.11.1990)
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Journal Article
Aromatic isosteres as conformational probes for an isoprenyl subunit: application to inhibitors of squalene synthase
Biller, Scott A., Abt, Jeffrey W., Pudzianowski, Andrew T., Rich, Lois C., Slusarchyk, Dorothy A., Ciosek, Carl.P.
Published in Bioorganic & medicinal chemistry letters (01.04.1993)
Published in Bioorganic & medicinal chemistry letters (01.04.1993)
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