A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers
Kenney, Richard T, Cini, John K, Dexter, Susan, DaFonseca, Manuel, Bingham, Justus, Kuan, Isabelle, Chawla, Sant P, Polasek, Thomas M, Lickliter, Jason, Ryan, Philip J
Published in Frontiers in immunology (29.02.2024)
Published in Frontiers in immunology (29.02.2024)
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Journal Article
Maternal Cognitive Impairment Associated with Gestational Diabetes Mellitus-A Review of Potential Contributing Mechanisms
John, Cini Mathew, Mohamed Yusof, Nur Intan Saidaah, Abdul Aziz, Siti Hajar, Mohd Fauzi, Fazlin
Published in International journal of molecular sciences (05.12.2018)
Published in International journal of molecular sciences (05.12.2018)
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Journal Article
SON-1210 - a novel bifunctional IL-12 / IL-15 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy
Cini, John K, Dexter, Susan, Rezac, Darrel J, McAndrew, Stephen J, Hedou, Gael, Brody, Rich, Eraslan, Rukiye-Nazan, Kenney, Richard T, Mohan, Pankaj
Published in Frontiers in immunology (2023)
Published in Frontiers in immunology (2023)
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Journal Article
Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes
Maqbool, Maryam, Algraittee, Satar Jabbar Rahi, Boroojerdi, Mohadese Hashem, Sarmadi, Vahid Hosseinpour, John, Cini Mathew, Vidyadaran, Sharmili, Ramasamy, Rajesh
Published in Innate immunity (London, England) (01.07.2020)
Published in Innate immunity (London, England) (01.07.2020)
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Journal Article
Pharmacological Targeting of KCa Channels to Improve Endothelial Function in the Spontaneously Hypertensive Rat
Khaddaj Mallat, Rayan, Mathew John, Cini, Mishra, Ramesh C, Kendrick, Dylan J, Braun, Andrew P
Published in International journal of molecular sciences (16.07.2019)
Published in International journal of molecular sciences (16.07.2019)
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Journal Article
Human Mesenchymal Stem Cells-mediated Transcriptomic Regulation of Leukemic Cells in Delivering Anti-tumorigenic Effects
Sarmadi, Vahid Hosseinpour, Ahmadloo, Salma, Boroojerdi, Mohadese Hashem, John, Cini Mathew, al-Graitte, Satar Jabbar Rahi, Lawal, Hamza, Maqbool, Maryam, Hwa, Ling King, Ramasamy, Rajesh
Published in Cell transplantation (01.01.2020)
Published in Cell transplantation (01.01.2020)
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Journal Article
Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen
Taha, Zaid, Arulanandam, Rozanne, Maznyi, Glib, Godbout, Elena, Carter-Timofte, Madalina E., Kurmasheva, Naziia, Reinert, Line S., Chen, Andrew, Crupi, Mathieu J.F., Boulton, Stephen, Laroche, Geneviève, Phan, Alexandra, Rezaei, Reza, Alluqmani, Nouf, Jirovec, Anna, Acal, Alexandra, Fekete, Emily E.F., Singaravelu, Ragunath, Petryk, Julia, Idorn, Manja, Potts, Kyle G., Todesco, Hayley, John, Cini, Mahoney, Douglas J., Ilkow, Carolina S., Giguère, Patrick, Alain, Tommy, Côté, Marceline, Paludan, Søren R., Olagnier, David, Bell, John C., Azad, Taha, Diallo, Jean-Simon
Published in Molecular Therapy (07.09.2022)
Published in Molecular Therapy (07.09.2022)
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Web Resource
High-titer manufacturing of SARS-CoV-2 Spike-pseudotyped VSV in stirred-tank bioreactors
Todesco, Hayley M., Gafuik, Chris, John, Cini M., Roberts, Erin L., Borys, Breanna S., Pawluk, Alexis, Kallos, Michael S., Potts, Kyle G., Mahoney, Douglas J.
Published in Molecular therapy. Methods & clinical development (14.03.2024)
Published in Molecular therapy. Methods & clinical development (14.03.2024)
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Journal Article
SKA-31, an activator of Ca2+-activated K+ channels, improves cardiovascular function in aging
John, Cini Mathew, Khaddaj Mallat, Rayan, Mishra, Ramesh C., George, Grace, Singh, Vikrant, Turnbull, Jeannine D., Umeshappa, Channakeshava S., Kendrick, Dylan J., Kim, Taeyeob, Fauzi, Fazlin M., Visser, Frank, Fedak, Paul W.M., Wulff, Heike, Braun, Andrew P.
Published in Pharmacological research (01.01.2020)
Published in Pharmacological research (01.01.2020)
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Journal Article
Effects of Pharmacological Inhibitors of NADPH Oxidase on Myogenic Contractility and Evoked Vasoactive Responses in Rat Resistance Arteries
Kendrick, Dylan J, Mishra, Ramesh C, John, Cini Mathew, Zhu, Hai-Lei, Braun, Andrew P
Published in Frontiers in physiology (24.01.2022)
Published in Frontiers in physiology (24.01.2022)
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Journal Article
Preliminary study on overproduction of reactive oxygen species by neutrophils in diabetes mellitus
Ridzuan, Noridzzaida, John, Cini Mathew, Sandrasaigaran, Pratheep, Maqbool, Maryam, Liew, Lee Chuen, Lim, Jonathan, Ramasamy, Rajesh
Published in World journal of diabetes (10.07.2016)
Published in World journal of diabetes (10.07.2016)
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Journal Article
Animal Model of Gestational Diabetes Mellitus with Pathophysiological Resemblance to the Human Condition Induced by Multiple Factors (Nutritional, Pharmacological, and Stress) in Rats
Mohd Fauzi, Fazlin, Ramasamy, Rajesh, Nordin, Massita, Mohamed Yusof, Nur Intan Saidaah, John, Cini Mathew, Abdul Aziz, Siti Hajar, Adam, Aishah
Published in BioMed research international (01.01.2016)
Published in BioMed research international (01.01.2016)
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Journal Article
Abstract 1589: Toxicity profile of interleukin 12 attached to a fully human albumin binding domain (FHABTM) in Cynomolgus macaques
Cini, John K., Rezac, Darrel J., McAndrew, Stephen, Dexter, Susan, Huebner, Robert, Borghaei, Hossein
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
SB221: A proof-of-concept study to assess the combination of SON-1010 (IL12-F H AB) and atezolizumab in patients with platinum-resistant ovarian cancer
Chawla, Sant P., Gao, Bo, Bampton, Carolyn L., Hamilton, Brett, Cini, John K., Dexter, Susan, Kenney, Richard T., Wenham, Robert Michael
Published in Journal of clinical oncology (01.06.2024)
Published in Journal of clinical oncology (01.06.2024)
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