First‐in‐human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection
Chughlay, M. Farouk, Rossignol, Emilie, Donini, Cristina, El Gaaloul, Myriam, Lorch, Ulrike, Coates, Simon, Langdon, Grant, Hammond, Tim, Möhrle, Jörg, Chalon, Stephan
Published in British journal of clinical pharmacology (01.06.2020)
Published in British journal of clinical pharmacology (01.06.2020)
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Unanticipated CNS Safety Signal in a Placebo‐Controlled, Randomized Trial of Co‐Administered Atovaquone‐Proguanil and Amodiaquine
Chalon, Stephan, Chughlay, M. Farouk, Abla, Nada, Marie Tchouatieu, Andre, Haouala, Amina, Hutter, Ben, Lorch, Ulrike, Macintyre, Fiona
Published in Clinical pharmacology and therapeutics (01.04.2022)
Published in Clinical pharmacology and therapeutics (01.04.2022)
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Safety, Tolerability, and Parasite Clearance Kinetics in Controlled Human Malaria Infection after Direct Venous Inoculation of Plasmodium falciparum Sporozoites: A Model for Evaluating New Blood-Stage Antimalarial Drugs
Chughlay, M. Farouk, Chalon, Stephan, El Gaaloul, Myriam, Gobeau, Nathalie, Möhrle, Jörg J., Berghmans, Pieter-Jan, Van Leuven, Katrin, Marx, Michael W., Rosanas-Urgell, Anna, Flynn, Julia, Escoffier, Emilie, Izquierdo-Juncàs, Daniel, Jansen, Bastiaan, Mitov, Venelin, Kümmel, Anne, Van Geertruyden, Jean-Pierre, Barnes, Karen I.
Published in The American journal of tropical medicine and hygiene (01.10.2022)
Published in The American journal of tropical medicine and hygiene (01.10.2022)
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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults
Chughlay, M Farouk, Barnes, Karen I, El Gaaloul, Myriam, Abla, Nada, Möhrle, Jörg J, Griffin, Paul, van Giersbergen, Paul, Reuter, Stephanie E, Schultz, Hayley B, Kress, Anita, Tapley, Peter, Webster, Rebecca A, Wells, Timothy, McCarthy, James S, Barber, Bridget E, Marquart, Louise, Boyle, Michelle J, Engwerda, Christian R, Chalon, Stephan
Published in Antimicrobial agents and chemotherapy (18.01.2022)
Published in Antimicrobial agents and chemotherapy (18.01.2022)
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OS-030 Efficacy and safety of xalnesiran with and without an immunomodulator in virologically suppressed participants with chronic hepatitis B: end of study results from the phase 2, randomized, controlled, adaptive, open-label platform study (PIRANGA)
Hou, Jinlin, Xie, Qing, Zhang, Wenhong, Hua, Rui, Tang, Hong, Gane, Edward J., Amado, Luis Enrique Morano, Yang, Sheng-Shun, Peng, Cheng-Yuan, Yuen, Man-Fung, Liang, Xieer, Wat, Cynthia, Cheng, Cong, Glavini, Katerina, Das, Sudip, Huang, Yan, Chughlay, Farouk, Guerreiro, Nelson, Chen, Ethan, Kakrana, Priyanka, Patil, Avinash, Upmanyu, Ruchi, Catanese, Maria Teresa, Kazma, Rémi, Asselah, Tarik
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
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Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical trialResearch in context
Nomathemba Chandiwana, Chelsea Kruger, Hilary Johnstone, Mohamed Farouk Chughlay, Chung Ju, Byungsu Kim, Yengiwe Dineka, Sarah Arbe-Barnes, Robert Miller, Andrew Owen, Andrew Hill, Daniel Windgassen, Nada Abla, Anne Claire Marrast, Stephan Duparc, Willem Daniel Francois Venter
Published in EBioMedicine (01.12.2022)
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Published in EBioMedicine (01.12.2022)
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Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study
Chughlay, Mohamed Farouk, El Gaaloul, Myriam, Donini, Cristina, Campo, Brice, Berghmans, Pieter-Jan, Lucardie, Alexander, Marx, Michael W, Cherkaoui-Rbati, Mohammed H, Langdon, Grant, Angulo-Barturen, Iñigo, Viera, Sara, Rosanas-Urgell, Anna, Van Geertruyden, Jean-Pierre, Chalon, Stephan
Published in The American journal of tropical medicine and hygiene (08.02.2021)
Published in The American journal of tropical medicine and hygiene (08.02.2021)
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Journal Article
Concentration‐QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers
Täubel, Jӧrg, Lorch, Ulrike, Ferber, Georg, Spencer, Christopher S., Freier, Anne, Coates, Simon, El Gaaloul, Myriam, Donini, Cristina, Chughlay, Mohamed Farouk, Chalon, Stephan
Published in British journal of clinical pharmacology (01.01.2022)
Published in British journal of clinical pharmacology (01.01.2022)
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Journal Article
Safety and efficacy of four drug regimens versus standard-of-care for the treatment of symptomatic outpatients with COVID-19: A randomised, open-label, multi-arm, phase 2 clinical trial
Chandiwana, Nomathemba, Kruger, Chelsea, Johnstone, Hilary, Chughlay, Mohamed Farouk, Ju, Chung, Kim, Byungsu, Dineka, Yengiwe, Arbe-Barnes, Sarah, Miller, Robert, Owen, Andrew, Hill, Andrew, Windgassen, Daniel, Abla, Nada, Marrast, Anne Claire, Duparc, Stephan, Francois Venter, Willem Daniel
Published in EBioMedicine (01.12.2022)
Published in EBioMedicine (01.12.2022)
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