Discovery of (2R)‑N‑[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]‑1H‑indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor
Su, Qibin, Banks, Erica, Bebernitz, Geraldine, Bell, Kirsten, Borenstein, Cassandra F, Chen, Huawei, Chuaqui, Claudio E, Deng, Nanhua, Ferguson, Andrew D, Kawatkar, Sameer, Grimster, Neil P, Ruston, Linette, Lyne, Paul D, Read, Jon A, Peng, Xianyou, Pei, Xiaohui, Fawell, Stephen, Tang, Zhanlei, Throner, Scott, Vasbinder, Melissa M, Wang, Haoyu, Winter-Holt, Jon, Woessner, Richard, Wu, Allan, Yang, Wenzhan, Zinda, Michael, Kettle, Jason G
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
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Journal Article
Discovery of (2 R )- N -[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1 H -indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor
Su, Qibin, Banks, Erica, Bebernitz, Geraldine, Bell, Kirsten, Borenstein, Cassandra F, Chen, Huawei, Chuaqui, Claudio E, Deng, Nanhua, Ferguson, Andrew D, Kawatkar, Sameer, Grimster, Neil P, Ruston, Linette, Lyne, Paul D, Read, Jon A, Peng, Xianyou, Pei, Xiaohui, Fawell, Stephen, Tang, Zhanlei, Throner, Scott, Vasbinder, Melissa M, Wang, Haoyu, Winter-Holt, Jon, Woessner, Richard, Wu, Allan, Yang, Wenzhan, Zinda, Michael, Kettle, Jason G
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
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SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model
Fu, Kai, Corbley, Michael J, Sun, Lihong, Friedman, Jessica E, Shan, Feng, Papadatos, James L, Costa, Donald, Lutterodt, Frank, Sweigard, Harry, Bowes, Scott, Choi, Michael, Boriack-Sjodin, P Ann, Arduini, Robert M, Sun, Dongyu, Newman, Miki N, Zhang, Xiamei, Mead, Jonathan N, Chuaqui, Claudio E, Cheung, H-Kam, Zhang, Xin, Cornebise, Mark, Carter, Mary Beth, Josiah, Serene, Singh, Juswinder, Lee, Wen-Cherng, Gill, Alan, Ling, Leona E
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2008)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.04.2008)
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Successful shape-based virtual screening: The discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)
JUSWINDER SINGH, CHUAQUI, Claudio E, PAPADATOS, James L, BOWES, Scott, JOSIAH, Serene, LING, Leona E, BORIACK-SJODIN, P. Ann, LEE, Wen-Cherng, PONTZ, Timothy, CORBLEY, Michael J, CHEUNG, H.-Kam, ARDUINI, Robert M, MEAD, Jonathan N, NEWMAN, Miki N
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Abstract B94: Discovery of and first disclosure of the clinical candidate AZD9291, a potent and selective third-generation EGFR inhibitor of both activating and T790M resistant mutations that spares the wild type form of the receptor
Finlay, M. Raymond V., Anderton, Mark, Ashton, Susan, Ballard, Peter G., Bradbury, Rob H., Butterworth, Sam, Chuaqui, Claudio E., Colclough, Nicola, Cross, Darren A. E., McFarland, Heather L., Mellor, Martine J., Ward, Richard A., Waring, Mike J.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Corrigendum to “Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFβ receptor kinase (TβRI)”: [Bioorg. Med. Chem. Lett. 13 (2003) 4355]
Singh, Juswinder, Chuaqui, Claudio E., Ann Boriack-Sjodin, P., Lee, Wen-Cherng, Pontz, Timothy, Corbley, Michael J., Cheung, H.-Kam, Arduini, Robert M., Mead, Jonathan N., Newman, Miki N., Papadatos, James L., Bowes, Scott, Josiah, Serene, Ling, Leona E.
Published in Bioorganic & medicinal chemistry letters (01.06.2004)
Published in Bioorganic & medicinal chemistry letters (01.06.2004)
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Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI)
Singh, Juswinder, Chuaqui, Claudio E, Boriack-Sjodin, P Ann, Lee, Wen Cherng, Pontz, Timothy, Corbley, Michael J, Cheung, H-Kam, Arduini, Robert M, Mead, Jonathan N, Newman, Miki N, Papadatos, James L, Bowes, Scott, Josiah, Serene, Ling, Leona E
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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HETEROCICLOS NITROGENADOS Y SU USO COMO ANTICANCERIGENOS
CHUAQUI, CLAUDIO E, SU, MEI, IOANNIDIS, STEPHANOS, SHI, JIE, HUANG, SHAN, SU, QIBIN
Year of Publication 28.10.2010
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Year of Publication 28.10.2010
Patent
DERIVADOS DE IMIDAZOL
CHUAQUI, CLAUDIO E, ALMEIDA, LYNSIE, IOANNIDIS, STEPHANOS, PENG, BO, LAMB, MICHELLE, GUAN, HUIPING, SU, QIBIN
Year of Publication 06.10.2010
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Year of Publication 06.10.2010
Patent
COMPUESTOS QUIMICOS DERIVADOS DE PIRAZOL-TRIAZINA
CHUAQUI, CLAUDIO E, ALMEIDA, LYNSIE, SU, MEI, PENG, BO, GUAN, HUIPING, SHI, JIE, AQUILA, BRIAN, HUANG, SHAN, SU, QUIBIN
Year of Publication 03.03.2010
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Year of Publication 03.03.2010
Patent