Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket
Tso, Shih-Chia, Qi, Xiangbing, Gui, Wen-Jun, Wu, Cheng-Yang, Chuang, Jacinta L., Wernstedt-Asterholm, Ingrid, Morlock, Lorraine K., Owens, Kyle R., Scherer, Philipp E., Williams, Noelle S., Tambar, Uttam K., Wynn, R. Max, Chuang, David T.
Published in The Journal of biological chemistry (14.02.2014)
Published in The Journal of biological chemistry (14.02.2014)
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Journal Article
Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase
Tso, Shih-Chia, Qi, Xiangbing, Gui, Wen-Jun, Chuang, Jacinta L., Morlock, Lorraine K., Wallace, Amy L., Ahmed, Kamran, Laxman, Sunil, Campeau, Philippe M., Lee, Brendan H., Hutson, Susan M., Tu, Benjamin P., Williams, Noelle S., Tambar, Uttam K., Wynn, R. Max, Chuang, David T.
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
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Journal Article
Lessons from Genetic Disorders of Branched-Chain Amino Acid Metabolism
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Journal Article
Conference Proceeding
Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice
Wu, Cheng-Yang, Tso, Shih-Chia, Chuang, Jacinta L., Gui, Wen-Jun, Lou, Mingliang, Sharma, Gaurav, Khemtong, Chalermchai, Qi, Xiangbing, Wynn, R. Max, Chuang, David T.
Published in Molecular metabolism (Germany) (01.06.2018)
Published in Molecular metabolism (Germany) (01.06.2018)
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Journal Article
Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity
Wynn, R. Max, Kato, Masato, Chuang, Jacinta L., Tso, Shih-Chia, Li, Jun, Chuang, David T.
Published in The Journal of biological chemistry (12.09.2008)
Published in The Journal of biological chemistry (12.09.2008)
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Journal Article
Structure of Rat BCKD Kinase: Nucleotide-Induced Domain Communication in a Mitochondrial Protein Kinase
Machius, Mischa, Chuang, Jacinta L., Wynn, R. Max, Tomchick, Diana R., Chuang, David T.
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (25.09.2001)
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Journal Article
Structural Determinants for Cross-talk between Pyruvate Dehydrogenase Kinase 3 and Lipoyl Domain 2 of the Human Pyruvate Dehydrogenase Complex
Tso, Shih-Chia, Kato, Masato, Chuang, Jacinta L., Chuang, David T.
Published in The Journal of biological chemistry (15.09.2006)
Published in The Journal of biological chemistry (15.09.2006)
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Journal Article
Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors
Tso, Shih-Chia, Lou, Mingliang, Wu, Cheng-Yang, Gui, Wen-Jun, Chuang, Jacinta L, Morlock, Lorraine K, Williams, Noelle S, Wynn, R. Max, Qi, Xiangbing, Chuang, David T
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Journal Article
Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase
Tso, Shih-Chia, Gui, Wen-Jun, Wu, Cheng-Yang, Chuang, Jacinta L., Qi, Xiangbing, Skvorak, Kristen J., Dorko, Kenneth, Wallace, Amy L., Morlock, Lorraine K., Lee, Brendan H., Hutson, Susan M., Strom, Stephen C., Williams, Noelle S., Tambar, Uttam K., Wynn, R.Max, Chuang, David T.
Published in The Journal of biological chemistry (25.07.2014)
Published in The Journal of biological chemistry (25.07.2014)
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Journal Article
Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops
Kato, Masato, Wynn, R. Max, Chuang, Jacinta L., Tso, Shih-Chia, Machius, Mischa, Li, Jun, Chuang, David T.
Published in Structure (London) (10.12.2008)
Published in Structure (London) (10.12.2008)
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Journal Article
Crystal Structure of Human Dihydrolipoamide Dehydrogenase: NAD +/NADH Binding and the Structural Basis of Disease-causing Mutations
Brautigam, Chad A., Chuang, Jacinta L., Tomchick, Diana R., Machius, Mischa, Chuang, David T.
Published in Journal of molecular biology (15.07.2005)
Published in Journal of molecular biology (15.07.2005)
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Journal Article
Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments
Padrick, Shae B., Deka, Ranjit K., Chuang, Jacinta L., Wynn, R. Max, Chuang, David T., Norgard, Michael V., Rosen, Michael K., Brautigam, Chad A.
Published in Analytical biochemistry (01.12.2010)
Published in Analytical biochemistry (01.12.2010)
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Journal Article
Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain α-Ketoacid Dehydrogenase Complex
Brautigam, Chad A., Wynn, R. Max, Chuang, Jacinta L., Naik, Mandar T., Young, Brittany B., Huang, Tai-huang, Chuang, David T.
Published in The Journal of biological chemistry (01.07.2011)
Published in The Journal of biological chemistry (01.07.2011)
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Journal Article
Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex
Brautigam, Chad A., Wynn, R. Max, Chuang, Jacinta L., Machius, Mischa, Tomchick, Diana R., Chuang, David T.
Published in Structure (London) (01.03.2006)
Published in Structure (London) (01.03.2006)
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Journal Article
A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain α-ketoacid dehydrogenase complex
Kato, Masato, Wynn, R Max, Chuang, Jacinta L, Brautigam, Chad A, Custorio, Myra, Chuang, David T
Published in The EMBO journal (13.12.2006)
Published in The EMBO journal (13.12.2006)
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