Search Results - "Chu, Seung" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats

A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats

by Moore, Gregory L., Bernett, Matthew J., Rashid, Rumana, Pong, Erik W., Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Nisthal, Alex, Diaz, Juan E., Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R.
Published in Methods (San Diego, Calif.) (01.02.2019)

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Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB

by Taoufik, Era, Tseveleki, Vivian, Chu, Seung Y., Tselios, Theodore, Karin, Michael, Lassmann, Hans, Szymkowski, David E., Probert, Lesley
Published in Brain (London, England : 1878) (01.09.2011)

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Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia

Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia

by HORTON, Holly M, BERNETT, Matthew J, DESJARLAIS, John R, ZHUKOVSKY, Eugene A, PONG, Erik, PEIPP, Matthias, KARKI, Sher, CHU, Seung Y, RICHARDS, John O, VOSTIAR, Igor, JOYCE, Patrick F, REPP, Roland
Published in Cancer research (Chicago, Ill.) (01.10.2008)

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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

by Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD
Published in Journal of allergy and clinical immunology (01.04.2012)

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Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis

Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis

by Turman, James M, Cheplowitz, Alana M, Tiwari, Charu, Thomas, Thushara, Joshi, Dhruvi, Bhat, Menakshi, Wu, Qian, Pong, Erik, Chu, Seung Y, Szymkowski, David E, Sharma, Amit, Seveau, Stephanie, Robinson, John M, Kwiek, Jesse J, Burton, Dennis, Rajaram, Murugesan V S, Kim, Jonghan, Hangartner, Lars, Ganesan, Latha P
Published in The Journal of immunology (1950) (15.03.2021)

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Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus

Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus

by Horton, Holly M, Chu, Seung Y, Ortiz, Elizabeth C, Pong, Erik, Cemerski, Saso, Leung, Irene W L, Jacob, Noam, Zalevsky, Jonathan, Desjarlais, John R, Stohl, William, Szymkowski, David E
Published in The Journal of immunology (1950) (01.04.2011)

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Retrospective analysis of efficacy and safety of oral paclitaxel for treatment of various cancers in dogs (2017–2021)

Retrospective analysis of efficacy and safety of oral paclitaxel for treatment of various cancers in dogs (2017–2021)

by Chae, Hyung‐Kyu, Oh, Ye‐In, Park, Sumin, An, Ju‐Hyun, Seo, Kyoungwon, Kang, Kyuyong, Chu, Seung‐nam, Youn, Hwa‐Young
Published in Veterinary medicine and science (01.07.2022)

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Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti‐CD19 Antibody That Coengages B Cell Antigen Receptor Complex and Fcγ Receptor IIb Inhibitory Receptor

Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti‐CD19 Antibody That Coengages B Cell Antigen Receptor Complex and Fcγ Receptor IIb Inhibitory Receptor

by Chu, Seung Y., Yeter, Karen, Kotha, Roshan, Pong, Erik, Miranda, Yvonne, Phung, Sheryl, Chen, Hsing, Lee, Sung‐Hyung, Leung, Irene, Bonzon, Christine, Desjarlais, John R., Stohl, William, Szymkowski, David E.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2014)

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Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies

Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies

by Horton, Holly M., Bernett, Matthew J., Peipp, Matthias, Pong, Erik, Karki, Sher, Chu, Seung Y., Richards, John O., Chen, Hsing, Repp, Roland, Desjarlais, John R., Zhukovsky, Eugene A.
Published in Blood (21.10.2010)

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A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens

A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens

by Moore, Gregory L., Bautista, Cristina, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Muchhal, Umesh S., Karki, Sher, Chu, Seung Y., Lazar, Greg A.
Published in mAbs (01.11.2011)

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Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective

Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective

by Desjarlais, John R., Lazar, Greg A., Zhukovsky, Eugene A., Chu, Seung Y.
Published in Drug discovery today (01.11.2007)

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Inhibition of B cell activation following in vivo co-engagement of B cell antigen receptor and Fcγ receptor IIb in non-autoimmune-prone and SLE-prone mice

Inhibition of B cell activation following in vivo co-engagement of B cell antigen receptor and Fcγ receptor IIb in non-autoimmune-prone and SLE-prone mice

by Chu, Seung Y., Pong, Erik, Bonzon, Christine, Yu, Ning, Jacob, Chaim O., Chalmers, Samantha A., Putterman, Chaim, Szymkowski, David E., Stohl, William
Published in Journal of translational autoimmunity (Online) (01.01.2021)

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The impact of Fc engineering on an anti-CD19 antibody: increased Fcγ receptor affinity enhances B-cell clearing in nonhuman primates

The impact of Fc engineering on an anti-CD19 antibody: increased Fcγ receptor affinity enhances B-cell clearing in nonhuman primates

by Zalevsky, Jonathan, Leung, Irene W.L., Karki, Sher, Chu, Seung Y., Zhukovsky, Eugene A., Desjarlais, John R., Carmichael, David F., Lawrence, Chris E.
Published in Blood (16.04.2009)

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Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function

Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function

by Tai, Yu-Tzu, Horton, Holly M., Kong, Sun-Young, Pong, Erik, Chen, Hsing, Cemerski, Saso, Bernett, Matthew J., Nguyen, Duc-Hanh T., Karki, Sher, Chu, Seung Y., Lazar, Greg A., Munshi, Nikhil C., Desjarlais, John R., Anderson, Kenneth C., Muchhal, Umesh S.
Published in Blood (01.03.2012)

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Osteogenesis of Adipose-Derived and Bone Marrow Stem Cells with Polycaprolactone/Tricalcium Phosphate and Three-Dimensional Printing Technology in a Dog Model of Maxillary Bone Defects

Osteogenesis of Adipose-Derived and Bone Marrow Stem Cells with Polycaprolactone/Tricalcium Phosphate and Three-Dimensional Printing Technology in a Dog Model of Maxillary Bone Defects

by Lee, Jeong Woo, Chu, Seung Gyun, Kim, Hak Tae, Choi, Kang Young, Oh, Eun Jung, Shim, Jin-Hyung, Yun, Won-Soo, Huh, Jung Bo, Moon, Sung Hwan, Kang, Seong Soo, Chung, Ho Yun
Published in Polymers (15.09.2017)

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Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies

by Chu, Seung Y., Vostiar, Igor, Karki, Sher, Moore, Gregory L., Lazar, Greg A., Pong, Erik, Joyce, Patrick F., Szymkowski, David E., Desjarlais, John R.
Published in Molecular immunology (01.09.2008)

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Abstract 5000: Immunotherapy with anti-PSMA x anti-CD3 bispecific antibody stimulates potent killing of a human prostate cancer cell line and target-mediated T cell activation in monkeys: A potential therapy for prostate cancer

Abstract 5000: Immunotherapy with anti-PSMA x anti-CD3 bispecific antibody stimulates potent killing of a human prostate cancer cell line and target-mediated T cell activation in monkeys: A potential therapy for prostate cancer

by Chu, Seung Y., Pong, Erik W. K., Rashid, Rumana, Chen, Hsing, Chan, Emily W., Phung, Sheryl, Endo, Nancy A., Ardila, Maria C., Bonzon, Christine, Leung, Irene W. L., Muchhal, Umesh S., Moore, Gregory L., Bernett, Matthew J., Desjarlais, John R., Szymkowski, David E.
Published in Cancer research (Chicago, Ill.) (15.07.2016)

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Suppression of mast cell degranulation through a dual-targeting tandem IgE–IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb

Suppression of mast cell degranulation through a dual-targeting tandem IgE–IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb

by Cemerski, Saso, Chu, Seung Y, Moore, Gregory L, Muchhal, Umesh S, Desjarlais, John R, Szymkowski, David E
Published in Immunology letters (30.03.2012)

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714 PD1 x TGFβR2 bispecifics selectively block TGFβR2 on PD1-positive T cells, promote T cell activation, and elicit an anti-tumor response in solid tumors

714 PD1 x TGFβR2 bispecifics selectively block TGFβR2 on PD1-positive T cells, promote T cell activation, and elicit an anti-tumor response in solid tumors

by Moore, Gregory, Schubbert, Suzanne, Bonzon, Christine, Avery, Kendra, Rashid, Rumana, Pong, Erik, Ochyl, Lukasz, Nisthal, Alex, Chu, Seung, Ernst, James, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2020)

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564 Potency-reduced and extended half-life IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity with potentially improved therapeutic index compared to native IL12 agents

564 Potency-reduced and extended half-life IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity with potentially improved therapeutic index compared to native IL12 agents

by Bernett, Matthew, Varma, Rajat, Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Chu, Seung, Muchhal, Umesh, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2020)

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