A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats
Moore, Gregory L., Bernett, Matthew J., Rashid, Rumana, Pong, Erik W., Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Nisthal, Alex, Diaz, Juan E., Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R.
Published in Methods (San Diego, Calif.) (01.02.2019)
Published in Methods (San Diego, Calif.) (01.02.2019)
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Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-κB
Taoufik, Era, Tseveleki, Vivian, Chu, Seung Y., Tselios, Theodore, Karin, Michael, Lassmann, Hans, Szymkowski, David E., Probert, Lesley
Published in Brain (London, England : 1878) (01.09.2011)
Published in Brain (London, England : 1878) (01.09.2011)
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Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia
HORTON, Holly M, BERNETT, Matthew J, DESJARLAIS, John R, ZHUKOVSKY, Eugene A, PONG, Erik, PEIPP, Matthias, KARKI, Sher, CHU, Seung Y, RICHARDS, John O, VOSTIAR, Igor, JOYCE, Patrick F, REPP, Roland
Published in Cancer research (Chicago, Ill.) (01.10.2008)
Published in Cancer research (Chicago, Ill.) (01.10.2008)
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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody
Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD
Published in Journal of allergy and clinical immunology (01.04.2012)
Published in Journal of allergy and clinical immunology (01.04.2012)
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Accelerated Clearance and Degradation of Cell-Free HIV by Neutralizing Antibodies Occurs via FcγRIIb on Liver Sinusoidal Endothelial Cells by Endocytosis
Turman, James M, Cheplowitz, Alana M, Tiwari, Charu, Thomas, Thushara, Joshi, Dhruvi, Bhat, Menakshi, Wu, Qian, Pong, Erik, Chu, Seung Y, Szymkowski, David E, Sharma, Amit, Seveau, Stephanie, Robinson, John M, Kwiek, Jesse J, Burton, Dennis, Rajaram, Murugesan V S, Kim, Jonghan, Hangartner, Lars, Ganesan, Latha P
Published in The Journal of immunology (1950) (15.03.2021)
Published in The Journal of immunology (1950) (15.03.2021)
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Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus
Horton, Holly M, Chu, Seung Y, Ortiz, Elizabeth C, Pong, Erik, Cemerski, Saso, Leung, Irene W L, Jacob, Noam, Zalevsky, Jonathan, Desjarlais, John R, Stohl, William, Szymkowski, David E
Published in The Journal of immunology (1950) (01.04.2011)
Published in The Journal of immunology (1950) (01.04.2011)
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Retrospective analysis of efficacy and safety of oral paclitaxel for treatment of various cancers in dogs (2017–2021)
Chae, Hyung‐Kyu, Oh, Ye‐In, Park, Sumin, An, Ju‐Hyun, Seo, Kyoungwon, Kang, Kyuyong, Chu, Seung‐nam, Youn, Hwa‐Young
Published in Veterinary medicine and science (01.07.2022)
Published in Veterinary medicine and science (01.07.2022)
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Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti‐CD19 Antibody That Coengages B Cell Antigen Receptor Complex and Fcγ Receptor IIb Inhibitory Receptor
Chu, Seung Y., Yeter, Karen, Kotha, Roshan, Pong, Erik, Miranda, Yvonne, Phung, Sheryl, Chen, Hsing, Lee, Sung‐Hyung, Leung, Irene, Bonzon, Christine, Desjarlais, John R., Stohl, William, Szymkowski, David E.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2014)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.05.2014)
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Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
Horton, Holly M., Bernett, Matthew J., Peipp, Matthias, Pong, Erik, Karki, Sher, Chu, Seung Y., Richards, John O., Chen, Hsing, Repp, Roland, Desjarlais, John R., Zhukovsky, Eugene A.
Published in Blood (21.10.2010)
Published in Blood (21.10.2010)
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A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens
Moore, Gregory L., Bautista, Cristina, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Muchhal, Umesh S., Karki, Sher, Chu, Seung Y., Lazar, Greg A.
Published in mAbs (01.11.2011)
Published in mAbs (01.11.2011)
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Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective
Desjarlais, John R., Lazar, Greg A., Zhukovsky, Eugene A., Chu, Seung Y.
Published in Drug discovery today (01.11.2007)
Published in Drug discovery today (01.11.2007)
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Inhibition of B cell activation following in vivo co-engagement of B cell antigen receptor and Fcγ receptor IIb in non-autoimmune-prone and SLE-prone mice
Chu, Seung Y., Pong, Erik, Bonzon, Christine, Yu, Ning, Jacob, Chaim O., Chalmers, Samantha A., Putterman, Chaim, Szymkowski, David E., Stohl, William
Published in Journal of translational autoimmunity (Online) (01.01.2021)
Published in Journal of translational autoimmunity (Online) (01.01.2021)
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The impact of Fc engineering on an anti-CD19 antibody: increased Fcγ receptor affinity enhances B-cell clearing in nonhuman primates
Zalevsky, Jonathan, Leung, Irene W.L., Karki, Sher, Chu, Seung Y., Zhukovsky, Eugene A., Desjarlais, John R., Carmichael, David F., Lawrence, Chris E.
Published in Blood (16.04.2009)
Published in Blood (16.04.2009)
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Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function
Tai, Yu-Tzu, Horton, Holly M., Kong, Sun-Young, Pong, Erik, Chen, Hsing, Cemerski, Saso, Bernett, Matthew J., Nguyen, Duc-Hanh T., Karki, Sher, Chu, Seung Y., Lazar, Greg A., Munshi, Nikhil C., Desjarlais, John R., Anderson, Kenneth C., Muchhal, Umesh S.
Published in Blood (01.03.2012)
Published in Blood (01.03.2012)
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Osteogenesis of Adipose-Derived and Bone Marrow Stem Cells with Polycaprolactone/Tricalcium Phosphate and Three-Dimensional Printing Technology in a Dog Model of Maxillary Bone Defects
Lee, Jeong Woo, Chu, Seung Gyun, Kim, Hak Tae, Choi, Kang Young, Oh, Eun Jung, Shim, Jin-Hyung, Yun, Won-Soo, Huh, Jung Bo, Moon, Sung Hwan, Kang, Seong Soo, Chung, Ho Yun
Published in Polymers (15.09.2017)
Published in Polymers (15.09.2017)
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Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcγRIIb with Fc-engineered antibodies
Chu, Seung Y., Vostiar, Igor, Karki, Sher, Moore, Gregory L., Lazar, Greg A., Pong, Erik, Joyce, Patrick F., Szymkowski, David E., Desjarlais, John R.
Published in Molecular immunology (01.09.2008)
Published in Molecular immunology (01.09.2008)
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Abstract 5000: Immunotherapy with anti-PSMA x anti-CD3 bispecific antibody stimulates potent killing of a human prostate cancer cell line and target-mediated T cell activation in monkeys: A potential therapy for prostate cancer
Chu, Seung Y., Pong, Erik W. K., Rashid, Rumana, Chen, Hsing, Chan, Emily W., Phung, Sheryl, Endo, Nancy A., Ardila, Maria C., Bonzon, Christine, Leung, Irene W. L., Muchhal, Umesh S., Moore, Gregory L., Bernett, Matthew J., Desjarlais, John R., Szymkowski, David E.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Suppression of mast cell degranulation through a dual-targeting tandem IgE–IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb
Cemerski, Saso, Chu, Seung Y, Moore, Gregory L, Muchhal, Umesh S, Desjarlais, John R, Szymkowski, David E
Published in Immunology letters (30.03.2012)
Published in Immunology letters (30.03.2012)
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714 PD1 x TGFβR2 bispecifics selectively block TGFβR2 on PD1-positive T cells, promote T cell activation, and elicit an anti-tumor response in solid tumors
Moore, Gregory, Schubbert, Suzanne, Bonzon, Christine, Avery, Kendra, Rashid, Rumana, Pong, Erik, Ochyl, Lukasz, Nisthal, Alex, Chu, Seung, Ernst, James, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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564 Potency-reduced and extended half-life IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity with potentially improved therapeutic index compared to native IL12 agents
Bernett, Matthew, Varma, Rajat, Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Chu, Seung, Muchhal, Umesh, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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