SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia
Mar, Brenton G., Chu, S. Haihua, Kahn, Josephine D., Krivtsov, Andrei V., Koche, Richard, Castellano, Cecilia A., Kotlier, Jacob L., Zon, Rebecca L., McConkey, Marie E., Chabon, Jonathan, Chappell, Ryan, Grauman, Peter V., Hsieh, James J., Armstrong, Scott A., Ebert, Benjamin L.
Published in Blood (14.12.2017)
Published in Blood (14.12.2017)
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miR-99 regulates normal and malignant hematopoietic stem cell self-renewal
Khalaj, Mona, Woolthuis, Carolien M, Hu, Wenhuo, Durham, Benjamin H, Chu, S Haihua, Qamar, Sarah, Armstrong, Scott A, Park, Christopher Y
Published in The Journal of experimental medicine (07.08.2017)
Published in The Journal of experimental medicine (07.08.2017)
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FLT3-ITD Knockin Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm
Chu, S. Haihua, Heiser, Diane, Li, Li, Kaplan, Ian, Collector, Michael, Huso, David, Sharkis, Saul J., Civin, Curt, Small, Don
Published in Cell stem cell (07.09.2012)
Published in Cell stem cell (07.09.2012)
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MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C
Zhu, Nan, Chen, Mo, Eng, Rowena, DeJong, Joshua, Sinha, Amit U, Rahnamay, Noushin F, Koche, Richard, Al-Shahrour, Fatima, Minehart, Janna C, Chen, Chun-Wei, Deshpande, Aniruddha J, Xu, Haiming, Chu, S Haihua, Ebert, Benjamin L, Roeder, Robert G, Armstrong, Scott A
Published in The Journal of clinical investigation (01.03.2016)
Published in The Journal of clinical investigation (01.03.2016)
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Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras
Chu, S. Haihua, Song, Evelyn J., Chabon, Jonathan R., Minehart, Janna, Matovina, Chloe N., Makofske, Jessica L., Frank, Elizabeth S., Ross, Kenneth, Koche, Richard P., Feng, Zhaohui, Xu, Haiming, Krivtsov, Andrei, Nussenzweig, Andre, Armstrong, Scott A.
Published in Blood advances (09.10.2018)
Published in Blood advances (09.10.2018)
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Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development
Chu, S. Haihua, Chabon, Jonathan R., Matovina, Chloe N., Minehart, Janna C., Chen, Bo-Ruei, Zhang, Jian, Kumar, Vipul, Xiong, Yijun, Callen, Elsa, Hung, Putzer J., Feng, Zhaohui, Koche, Richard P., Liu, X. Shirley, Chaudhuri, Jayanta, Nussenzweig, Andre, Sleckman, Barry P., Armstrong, Scott A.
Published in iScience (27.03.2020)
Published in iScience (27.03.2020)
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Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis
Hérault, Aurélie, Binnewies, Mikhail, Leong, Stephanie, Calero-Nieto, Fernando J., Zhang, Si Yi, Kang, Yoon-A, Wang, Xiaonan, Pietras, Eric M., Chu, S. Haihua, Barry-Holson, Keegan, Armstrong, Scott, Göttgens, Berthold, Passegué, Emmanuelle
Published in Nature (London) (06.04.2017)
Published in Nature (London) (06.04.2017)
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NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis
Xu, Haiming, Valerio, Daria G., Eisold, Meghan E., Sinha, Amit, Koche, Richard P., Hu, Wenhuo, Chen, Chun-Wei, Chu, S. Haihua, Brien, Gerard L., Park, Christopher Y., Hsieh, James J., Ernst, Patricia, Armstrong, Scott A.
Published in Cancer cell (12.12.2016)
Published in Cancer cell (12.12.2016)
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Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition
Zhu, Ruiqi, Shirley, Courtney M., Chu, S. Haihua, Li, Li, Nguyen, Bao H., Seo, Jaesung, Wu, Min, Seale, Tessa, Duffield, Amy S., Staudt, Louis M., Levis, Mark, Hu, Yu, Small, Donald
Published in Leukemia (01.07.2024)
Published in Leukemia (01.07.2024)
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Resistance Mechanisms to SYK Inhibition in Acute Myeloid Leukemia
Cremer, Anjali, Ellegast, Jana M, Alexe, Gabriela, Frank, Elizabeth S, Ross, Linda, Chu, S Haihua, Pikman, Yana, Robichaud, Amanda, Goodale, Amy, Häupl, Björn, Mohr, Sebastian, Rao, Arati V, Walker, Alison R, Blachly, James S, Piccioni, Federica, Armstrong, Scott A, Byrd, John C, Oellerich, Thomas, Stegmaier, Kimberly
Published in Cancer discovery (01.02.2020)
Published in Cancer discovery (01.02.2020)
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Rationally Designed Base Editors for Precise Editing of the Sickle Cell Disease Mutation
Chu, S Haihua, Packer, Michael, Rees, Holly, Lam, Dieter, Yu, Yi, Marshall, Jeffrey, Cheng, Lo-I, Lam, Daisy, Olins, Jenny, Ran, Fei Ann, Liquori, Alexander, Gantzer, Bob, Decker, Jeremy, Born, David, Barrera, Luis, Hartigan, Adam, Gaudelli, Nicole, Ciaramella, Giuseppe, Slaymaker, Ian M
Published in CRISPR journal (01.04.2021)
Published in CRISPR journal (01.04.2021)
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Journal Article
Leukemia Cell of Origin Influences Apoptotic Priming and Sensitivity to LSD1 Inhibition
Cai, Sheng F, Chu, S Haihua, Goldberg, Aaron D, Parvin, Salma, Koche, Richard P, Glass, Jacob L, Stein, Eytan M, Tallman, Martin S, Sen, Filiz, Famulare, Christopher A, Cusan, Monica, Huang, Chun-Hao, Chen, Chun-Wei, Zou, Lihua, Cordner, Keith B, DelGaudio, Nicole L, Durani, Vidushi, Kini, Mitali, Rex, Madison, Tian, Helen S, Zuber, Johannes, Baslan, Timour, Lowe, Scott W, Rienhoff, Jr, Hugh Y, Letai, Anthony, Levine, Ross L, Armstrong, Scott A
Published in Cancer discovery (01.10.2020)
Published in Cancer discovery (01.10.2020)
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Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplant through Engineered Stem Cell Antibody Paired Evasion (ESCAPE)
Mondal, Nandini, Harmon, Alexander, Budak, Elizabeth, Zhang, Kathy, Wong, Jeffrey, Menon, Archita Venugopal, Wolin, Adam, White, Moriah, Musenge, Faith, Camblin, Adam, Coisman, Brent, Lucini, Corrina, Bai, Tao, Qiao, Kangjian, Austin, Wayne, DeLelys, Michelle, Kromer, Hugh, Hardy, Lisa, Law, Megan, Manoukian, Raffi, Goldsmith, Rachel, Fallon, Kiera, Patel, Mudra, Cozier, Antoinette, Lazzara, Colin, Decker, Jeremy, Jenkins, Rebecca, Bohnuud, Tanggis, Feliciano, Patricia, Lee, Seung-Joo, Kopesky, Paul, Smith, Sarah, McDonagh, Charlotte, Gaudelli, Nicole, Chu, S. Haihua, Hartigan, Adam, Shankar, Gopi, Ciaramella, Giuseppe
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Engineered Stem Cell Antibody Paired Evasion 1 (ESCAPE-1): Paired HSC Epitope Engineering and Upregulation of Fetal Hemoglobin for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Hemoglobinopathies
Mondal, Nandini, Harmon, Alexander, Budak, Elizabeth, Zhang, Kathy, Wong, Jeffrey, Rinaldi, Conrad, Olins, Jenny, Hoar, Kara, Menon, Archita Venugopal, White, Moriah, Musenge, Faith, Camblin, Adam, Wolin, Adam, Coisman, Brent, Bai, Tao, Qiao, Kangjian, Patel, Mudra, Decker, Jeremy, Gantzer, Bob, Leete, Thomas, Yu, Yi, Bohnuud, Tanggis, Lee, Seung-Joo, Smith, Sarah, McDonagh, Charlotte F, Gaudelli, Nicole M., Chu, S. Haihua, Hartigan, Adam J., Ciaramella, Giuseppe
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Engineered Stem Cell Antibody Paired Evasion-2 (ESCAPE-2): Paired HSC Epitope Engineering and Direct Editing of Sickle Allele for Antibody-Mediated Autologous Hematopoietic Stem Cell Therapy Conditioning for the Treatment of Sickle Cell Disease
Chu, S. Haihua, Budak, Elizabeth, Mondal, Nandini, Zhang, Kathy, Harmon, Alexander, Wong, Jeffrey, Lam, Dieter, Lucini, Corrina, Coisman, Brent, Qiao, Kangjian, Bai, Tao, Decker, Jeremy, Gantzer, Bob, Lee, Kindo, Sen, Maya, Bohnuud, Tanggis, Barrera, Luis, Cafferty, Brian, Lee, Seung-Joo, Kopesky, Paul, Gaudelli, Nicole M., McDonagh, Charlotte F, Ciaramella, Giuseppe, Hartigan, Adam J.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Adenine Base Editing of the Sickle Allele in CD34+ Hematopoietic Stem and Progenitor Cells Eliminates Hemoglobin S
Chu, S. Haihua, Lam, Daisy, Packer, Michael S., Olins, Jennifer, Liquori, Alexander, Marshall, Jeffrey, Lee, Calvin, Yan, Bo, Decker, Jeremy, Gantzer, Bob, Haskett, Scott J., Bohnuud, Tanggis, Born, David, Barrera, Luis, Slaymaker, Ian, Gaudelli, Nicole M., Hartigan, Adam J., Ciaramella, Giuseppe
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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