Allosteric targeting of receptor tyrosine kinases
De Smet, Frederik, Christopoulos, Arthur, Carmeliet, Peter
Published in Nature biotechnology (01.11.2014)
Published in Nature biotechnology (01.11.2014)
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THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets
Alexander, Stephen PH, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Buneman, O Peter, Cidlowski, John A, Christopoulos, Arthur, Davenport, Anthony P, Fabbro, Doriano, Spedding, Michael, Striessnig, Jörg, Davies, Jamie A, Arumugam, Thiruma V, Bennett, Andrew, Sjögren, Benita, Sobey, Christopher, Wong, Szu Shen
Published in British journal of pharmacology (01.12.2019)
Published in British journal of pharmacology (01.12.2019)
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors
Alexander, Stephen PH, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Marrion, Neil V, Peters, John A, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A
Published in British journal of pharmacology (01.12.2017)
Published in British journal of pharmacology (01.12.2017)
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Phase-plate cryo-EM structure of a class B GPCR-G-protein complex
Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M, Furness, Sebastian G B, Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J, Christopoulos, Arthur, Kobilka, Brian K, Wootten, Denise, Skiniotis, Georgios, Sexton, Patrick M
Published in Nature (London) (01.06.2017)
Published in Nature (London) (01.06.2017)
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Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity
Glukhova, Alisa, Thal, David M., Nguyen, Anh T., Vecchio, Elizabeth A., Jörg, Manuela, Scammells, Peter J., May, Lauren T., Sexton, Patrick M., Christopoulos, Arthur
Published in Cell (23.02.2017)
Published in Cell (23.02.2017)
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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
Jeffrey Conn, P, Christopoulos, Arthur, Lindsley, Craig W
Published in Nature reviews. Drug discovery (01.01.2009)
Published in Nature reviews. Drug discovery (01.01.2009)
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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex
Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G B, Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T, Thal, David M, Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J, Christopoulos, Arthur, Sexton, Patrick M, Wootten, Denise
Published in Nature (London) (01.03.2018)
Published in Nature (London) (01.03.2018)
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Activation and allosteric modulation of a muscarinic acetylcholine receptor
Kruse, Andrew C, Ring, Aaron M, Manglik, Aashish, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Hübner, Harald, Pardon, Els, Valant, Celine, Sexton, Patrick M, Christopoulos, Arthur, Felder, Christian C, Gmeiner, Peter, Steyaert, Jan, Weis, William I, Garcia, K Christopher, Wess, Jürgen, Kobilka, Brian K
Published in Nature (London) (05.12.2013)
Published in Nature (London) (05.12.2013)
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Bridging the gap: bitopic ligands of G-protein-coupled receptors
Lane, J. Robert, Sexton, Patrick M, Christopoulos, Arthur
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2013)
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2013)
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Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
Liang, Yi-Lynn, Khoshouei, Maryam, Deganutti, Giuseppe, Glukhova, Alisa, Koole, Cassandra, Peat, Thomas S., Radjainia, Mazdak, Plitzko, Jürgen M., Baumeister, Wolfgang, Miller, Laurence J., Hay, Deborah L., Christopoulos, Arthur, Reynolds, Christopher A., Wootten, Denise, Sexton, Patrick M.
Published in Nature (London) (01.09.2018)
Published in Nature (London) (01.09.2018)
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Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
Wootten, Denise, Simms, John, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2013)
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Allostery and Biased Agonism at Class B G Protein-Coupled Receptors
Wootten, Denise, Miller, Laurence J, Koole, Cassandra, Christopoulos, Arthur, Sexton, Patrick M
Published in Chemical reviews (11.01.2017)
Published in Chemical reviews (11.01.2017)
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Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor
Leach, Katie, Gregory, Karen J, Kufareva, Irina, Khajehali, Elham, Cook, Anna E, Abagyan, Ruben, Conigrave, Arthur D, Sexton, Patrick M, Christopoulos, Arthur
Published in Cell research (01.05.2016)
Published in Cell research (01.05.2016)
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Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
Thal, David M, Sun, Bingfa, Feng, Dan, Nawaratne, Vindhya, Leach, Katie, Felder, Christian C, Bures, Mark G, Evans, David A, Weis, William I, Bachhawat, Priti, Kobilka, Tong Sun, Sexton, Patrick M, Kobilka, Brian K, Christopoulos, Arthur
Published in Nature (London) (17.03.2016)
Published in Nature (London) (17.03.2016)
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The role of kinetic context in apparent biased agonism at GPCRs
Klein Herenbrink, Carmen, Sykes, David A, Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J, Capuano, Ben, Sexton, Patrick M, Charlton, Steven J, Javitch, Jonathan A, Christopoulos, Arthur, Lane, J Robert
Published in Nature communications (24.02.2016)
Published in Nature communications (24.02.2016)
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A kinetic view of GPCR allostery and biased agonism
Lane, J Robert, May, Lauren T, Parton, Robert G, Sexton, Patrick M, Christopoulos, Arthur
Published in Nature chemical biology (18.08.2017)
Published in Nature chemical biology (18.08.2017)
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Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology
Leach, Katie, Sexton, Patrick M, Christopoulos, Arthur
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2007)
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2007)
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