Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis
Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Joncour, Agnès, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Rondet, Emilie, Peixoto, Christophe, Grassot, Jean-Marie, Picolet, Olivier, Annoot, Denis, Triballeau, Nicolas, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Blanque, Roland, Cottereaux, Celine, Vandervoort, Nele, Christophe, Thierry, Mollat, Patrick, Lamers, Marieke, Auberval, Marielle, Hrvacic, Boska, Ralic, Jovica, Oste, Line, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
Discovery of Diarylhydantoins as New Selective Androgen Receptor Modulators
Nique, François, Hebbe, Séverine, Peixoto, Christophe, Annoot, Denis, Lefrançois, Jean-Michel, Duval, Eric, Michoux, Laurence, Triballeau, Nicolas, Lemoullec, Jean-Michel, Mollat, Patrick, Thauvin, Maxime, Prangé, Thierry, Minet, Dominique, Clément-Lacroix, Philippe, Robin-Jagerschmidt, Catherine, Fleury, Damien, Guédin, Denis, Deprez, Pierre
Published in Journal of medicinal chemistry (11.10.2012)
Published in Journal of medicinal chemistry (11.10.2012)
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Journal Article
Identification of a 4‑(Hydroxymethyl)diarylhydantoin as a Selective Androgen Receptor Modulator
Nique, François, Hebbe, Séverine, Triballeau, Nicolas, Peixoto, Christophe, Lefrançois, Jean-Michel, Jary, Hélène, Alvey, Luke, Manioc, Murielle, Housseman, Christopher, Klaassen, Hugo, Van Beeck, Kris, Guédin, Denis, Namour, Florence, Minet, Dominque, Van der Aar, Ellen, Feyen, Jean, Fletcher, Stephen, Blanqué, Roland, Robin-Jagerschmidt, Catherine, Deprez, Pierre
Published in Journal of medicinal chemistry (11.10.2012)
Published in Journal of medicinal chemistry (11.10.2012)
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Journal Article
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS‑5 Inhibitor for the Treatment of Osteoarthritis
Brebion, Franck, Gosmini, Romain, Deprez, Pierre, Varin, Marie, Peixoto, Christophe, Alvey, Luke, Jary, Hélène, Bienvenu, Natacha, Triballeau, Nicolas, Blanque, Roland, Cottereaux, Céline, Christophe, Thierry, Vandervoort, Nele, Mollat, Patrick, Touitou, Robert, Leonard, Philip, Ceuninck, Frédéric De, Botez, Iuliana, Monjardet, Alain, van der Aar, Ellen, Amantini, David
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Journal Article
Optimization of Selectivity and Pharmacokinetic Properties of Salt‑Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312
Temal-Laib, Taouès, Peixoto, Christophe, Desroy, Nicolas, De Lemos, Elsa, Bonnaterre, Florence, Bienvenu, Natacha, Picolet, Olivier, Sartori, Eric, Bucher, Denis, López-Ramos, Miriam, Roca Magadán, Carlos, Laenen, Wendy, Flower, Thomas, Mollat, Patrick, Bugaud, Olivier, Touitou, Robert, Pereira Fernandes, Anna, Lavazais, Stephanie, Monjardet, Alain, Borgonovi, Monica, Gosmini, Romain, Brys, Reginald, Amantini, David, De Vos, Steve, Andrews, Martin
Published in Journal of medicinal chemistry (11.01.2024)
Published in Journal of medicinal chemistry (11.01.2024)
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Journal Article
Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases
Peixoto, Christophe, Joncour, Agnes, Temal-Laib, Taouès, Tirera, Amynata, Dos Santos, Aurélie, Jary, Hélène, Bucher, Denis, Laenen, Wendy, Pereira Fernandes, Anna, Lavazais, Stephanie, Delachaume, Carole, Merciris, Didier, Saccomani, Corinne, Drennan, Michael, López-Ramos, Miriam, Wakselman, Emanuelle, Dupont, Sonia, Borgonovi, Monica, Roca Magadan, Carlos, Monjardet, Alain, Brys, Reginald, De Vos, Steve, Andrews, Martin, Jimenez, Juan-Miguel, Amantini, David, Desroy, Nicolas
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
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Journal Article
Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors
Joncour, Agnès, Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Peixoto, Christophe, Annoot, Denis, Lepissier, Luce, Heiermann, Jörg, Hengeveld, Willem Jan, Pilzak, Gregor, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Galien, René, David, Christelle, Vandervoort, Nele, Christophe, Thierry, Conrath, Katja, Jans, Mia, Wohlkonig, Alexandre, Soror, Sameh, Steyaert, Jan, Touitou, Robert, Fleury, Damien, Vercheval, Lionel, Mollat, Patrick, Triballeau, Nicolas, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand
Published in Journal of medicinal chemistry (14.09.2017)
Published in Journal of medicinal chemistry (14.09.2017)
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Journal Article
Correction to Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors
Joncour, Agnès, Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Peixoto, Christophe, Annoot, Denis, Lepissier, Luce, Heiermann, Jörg, Hengeveld, Willem Jan, Pilzak, Gregor, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Galien, René, David, Christelle, Vandervoort, Nele, Christophe, Thierry, Conrath, Katja, Jans, Mia, Wohlkonig, Alexandre, Soror, Sameh, Steyaert, Jan, Touitou, Robert, Fleury, Damien, Vercheval, Lionel, Mollat, Patrick, Triballeau, Nicolas, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand
Published in Journal of medicinal chemistry (10.05.2018)
Published in Journal of medicinal chemistry (10.05.2018)
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A Quality Model for Spreadsheets
Cunha, J., Fernandes, J. P., Peixoto, C., Saraiva, J.
Published in 2012 Eighth International Conference on the Quality of Information and Communications Technology (01.09.2012)
Published in 2012 Eighth International Conference on the Quality of Information and Communications Technology (01.09.2012)
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Conference Proceeding
5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR TREATMENT OF OSTEOARTHRITIS
MARIE LAURENCE CLAIRE VARIN, DAVID AMANTINI, CHRISTOPHE PEIXOTO, LUKE JONATHAN ALVEY, PIERRE MARC MARIE JOSEPH DEPREZ, FRANCK LAURENT BREBION, ROMAIN LUC MARIE GOSMINI, IULIANA ECATERINA POP-BOTEZ, HELENE MARIE JARY, FREDERIC ANDRE DE CEUNINCK
Year of Publication 23.04.2020
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Year of Publication 23.04.2020
Patent
Discovery of 2‑[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2‑a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis
Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Joncour, Agnès, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Rondet, Emilie, Peixoto, Christophe, Grassot, Jean-Marie, Picolet, Olivier, Annoot, Denis, Triballeau, Nicolas, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Blanque, Roland, Cottereaux, Celine, Vandervoort, Nele, Christophe, Thierry, Mollat, Patrick, Lamers, Marieke, Auberval, Marielle, Hrvacic, Boska, Ralic, Jovica, Oste, Line, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand
Published in Journal of medicinal chemistry (11.05.2017)
Published in Journal of medicinal chemistry (11.05.2017)
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Journal Article
NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES
DESROY, NICOLAS, TEMAL-LAÏB, TAOUES, BUCHER, DENIS, BONNATERRE, FLORENCE MARIE-EMILIE, ALVEY, LUKE JONATHAN, JARY, HÉLÈNE MARIE, DUTHION, BÉRANGER, PEIXOTO, CHRISTOPHE, TIRERA, AMYNATA
Year of Publication 09.09.2024
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Year of Publication 09.09.2024
Patent
Compounds and pharmaceutical compositions thereof for the treatment of diseases
Duthion, Béranger, Alvey, Luke Jonathan, Bonnaterre, Florence Marie-Emilie, Temal-Laib, Taoues, Tirera, Amynata, Peixoto, Christophe, Desroy, Nicolas, Annoot, Denis Maurice, Bucher, Denis, Jary, Hélène Marie
Year of Publication 20.08.2024
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Year of Publication 20.08.2024
Patent
NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES
TIRERA, Amynata, ALVEY, Luke, Jonathan, DUTHION, Béranger, DESROY, Nicolas, BONNATERRE, Florence, Marie-Emilie, TEMAL-LAÏB, Taoues, BUCHER, Denis, PEIXOTO, Christophe, JARY, Hélène, Marie
Year of Publication 03.07.2024
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Year of Publication 03.07.2024
Patent
NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES
TIRERA, Amynata, ALVEY, Luke, Jonathan, DUTHION, Béranger, DESROY, Nicolas, BONNATERRE, Florence, Marie-Emilie, TEMAL-LAÏB, Taoues, BUCHER, Denis, PEIXOTO, Christophe, JARY, Hélène, Marie
Year of Publication 03.07.2024
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Year of Publication 03.07.2024
Patent