Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics
Schroeder, Simon, Pott, Fabian, Niemeyer, Daniela, Veith, Talitha, Richter, Anja, Muth, Doreen, Goffinet, Christine, Müller, Marcel A, Drosten, Christian
Published in The Lancet. Microbe (01.05.2021)
Published in The Lancet. Microbe (01.05.2021)
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Interferon‐inducible cholesterol‐25‐hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation
Anggakusuma, Romero‐Brey, Inés, Berger, Carola, Colpitts, Che C., Boldanova, Tujana, Engelmann, Michael, Todt, Daniel, Perin, Paula Monteiro, Behrendt, Patrick, Vondran, Florian W.R., Xu, Shuting, Goffinet, Christine, Schang, Luis M., Heim, Markus H., Bartenschlager, Ralf, Pietschmann, Thomas, Steinmann, Eike
Published in Hepatology (Baltimore, Md.) (01.09.2015)
Published in Hepatology (Baltimore, Md.) (01.09.2015)
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SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression
Niemeyer, Daniela, Stenzel, Saskia, Veith, Talitha, Schroeder, Simon, Friedmann, Kirstin, Weege, Friderike, Trimpert, Jakob, Heinze, Julian, Richter, Anja, Jansen, Jenny, Emanuel, Jackson, Kazmierski, Julia, Pott, Fabian, Jeworowski, Lara M, Olmer, Ruth, Jaboreck, Mark-Christian, Tenner, Beate, Papies, Jan, Walper, Felix, Schmidt, Marie L, Heinemann, Nicolas, Möncke-Buchner, Elisabeth, Baumgardt, Morris, Hoffmann, Karen, Widera, Marek, Thao, Tran Thi Nhu, Balázs, Anita, Schulze, Jessica, Mache, Christin, Jones, Terry C, Morkel, Markus, Ciesek, Sandra, Hanitsch, Leif G, Mall, Marcus A, Hocke, Andreas C, Thiel, Volker, Osterrieder, Klaus, Wolff, Thorsten, Martin, Ulrich, Corman, Victor M, Müller, Marcel A, Goffinet, Christine, Drosten, Christian
Published in PLoS biology (16.11.2022)
Published in PLoS biology (16.11.2022)
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Labyrinthopeptins Exert Broad-Spectrum Antiviral Activity through Lipid-Binding-Mediated Virolysis
Prochnow, Hans, Rox, Katharina, Birudukota, N V Suryanarayana, Weichert, Loreen, Hotop, Sven-Kevin, Klahn, Philipp, Mohr, Kathrin, Franz, Sergej, Banda, Dominic H, Blockus, Sebastian, Schreiber, Janine, Haid, Sibylle, Oeyen, Merel, Martinez, Javier P, Süssmuth, Roderich D, Wink, Joachim, Meyerhans, Andreas, Goffinet, Christine, Messerle, Martin, Schulz, Thomas F, Kröger, Andrea, Schols, Dominique, Pietschmann, Thomas, Brönstrup, Mark
Published in Journal of virology (06.01.2020)
Published in Journal of virology (06.01.2020)
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Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor
Passos, Vânia, Zillinger, Thomas, Casartelli, Nicoletta, Wachs, Amelie S, Xu, Shuting, Malassa, Angelina, Steppich, Katja, Schilling, Hildegard, Franz, Sergej, Todt, Daniel, Steinmann, Eike, Sutter, Kathrin, Dittmer, Ulf, Bohne, Jens, Schwartz, Olivier, Barchet, Winfried, Goffinet, Christine
Published in Journal of virology (01.12.2019)
Published in Journal of virology (01.12.2019)
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Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 Therapy
Hoffmann, Markus, Sidarovich, Anzhalika, Arora, Prerna, Krüger, Nadine, Nehlmeier, Inga, Kempf, Amy, Graichen, Luise, Winkler, Martin S, Niemeyer, Daniela, Goffinet, Christine, Drosten, Christian, Schulz, Sebastian, Jäck, Hans-Martin, Pöhlmann, Stefan
Published in mBio (28.06.2022)
Published in mBio (28.06.2022)
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cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites
Xu, Shuting, Ducroux, Aurélie, Ponnurangam, Aparna, Vieyres, Gabrielle, Franz, Sergej, Müsken, Mathias, Zillinger, Thomas, Malassa, Angelina, Ewald, Ellen, Hornung, Veit, Barchet, Winfried, Häussler, Susanne, Pietschmann, Thomas, Goffinet, Christine
Published in Cell host & microbe (12.10.2016)
Published in Cell host & microbe (12.10.2016)
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Dysfunctional purinergic signaling correlates with disease severity in COVID-19 patients
Pietrobon, Anna Julia, Andrejew, Roberta, Custódio, Ricardo Wesley Alberca, Oliveira, Luana de Mendonça, Scholl, Juliete Nathali, Teixeira, Franciane Mouradian Emidio, de Brito, Cyro Alves, Glaser, Talita, Kazmierski, Julia, Goffinet, Christine, Turdo, Anna Claudia, Yendo, Tatiana, Aoki, Valeria, Figueiró, Fabricio, Battastini, Ana Maria, Ulrich, Henning, Benard, Gill, Duarte, Alberto Jose da Silva, Sato, Maria Notomi
Published in Frontiers in immunology (30.09.2022)
Published in Frontiers in immunology (30.09.2022)
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The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication
Lasswitz, Lisa, Zapatero-Belinchón, Francisco J, Moeller, Rebecca, Hülskötter, Kirsten, Laurent, Timothée, Carlson, Lars-Anders, Goffinet, Christine, Simmons, Graham, Baumgärtner, Wolfgang, Gerold, Gisa
Published in mBio (28.06.2022)
Published in mBio (28.06.2022)
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Nonproductive exposure of PBMCs to SARS‐CoV‐2 induces cell‐intrinsic innate immune responses
Kazmierski, Julia, Friedmann, Kirstin, Postmus, Dylan, Emanuel, Jackson, Fischer, Cornelius, Jansen, Jenny, Richter, Anja, Bosquillon de Jarcy, Laure, Schüler, Christiane, Sohn, Madlen, Sauer, Sascha, Drosten, Christian, Saliba, Antoine‐Emmanuel, Sander, Leif Erik, Müller, Marcel A, Niemeyer, Daniela, Goffinet, Christine
Published in Molecular systems biology (01.08.2022)
Published in Molecular systems biology (01.08.2022)
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Single-cell-resolved interspecies comparison shows a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19
Peidli, Stefan, Nouailles, Geraldine, Wyler, Emanuel, Adler, Julia M., Kunder, Sandra, Voß, Anne, Kazmierski, Julia, Pott, Fabian, Pennitz, Peter, Postmus, Dylan, Teixeira Alves, Luiz Gustavo, Goffinet, Christine, Gruber, Achim D., Blüthgen, Nils, Witzenrath, Martin, Trimpert, Jakob, Landthaler, Markus, Praktiknjo, Samantha D.
Published in Cell reports (Cambridge) (25.06.2024)
Published in Cell reports (Cambridge) (25.06.2024)
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HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor
Goffinet, Christine, Allespach, Ina, Homann, Stefanie, Tervo, Hanna-Mari, Habermann, Anja, Rupp, Daniel, Oberbremer, Lena, Kern, Christian, Tibroni, Nadine, Welsch, Sonja, Krijnse-Locker, Jacomine, Banting, George, Kräusslich, Hans-Georg, Fackler, Oliver T, Keppler, Oliver T
Published in Cell host & microbe (19.03.2009)
Published in Cell host & microbe (19.03.2009)
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Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection
Mhlekude, Baxolele, Postmus, Dylan, Stenzel, Saskia, Weiner, 3rd, January, Jansen, Jenny, Zapatero-Belinchón, Francisco J, Olmer, Ruth, Richter, Anja, Heinze, Julian, Heinemann, Nicolas, Mühlemann, Barbara, Schroeder, Simon, Jones, Terry C, Müller, Marcel A, Drosten, Christian, Pich, Andreas, Thiel, Volker, Martin, Ulrich, Niemeyer, Daniela, Gerold, Gisa, Beule, Dieter, Goffinet, Christine
Published in PLoS pathogens (25.09.2023)
Published in PLoS pathogens (25.09.2023)
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In vivo expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans
Erikson, Elina, Adam, Tarek, Schmidt, Sarah, Lehmann-Koch, Judith, Over, Benjamin, Goffinet, Christine, Harter, Christoph, Bekeredjian-Ding, Isabelle, Sertel, Serkan, Lasitschka, Felix, Keppler, Oliver T
Published in Proceedings of the National Academy of Sciences - PNAS (16.08.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (16.08.2011)
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SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
Kmiec, Dorota, Akbil, Bengisu, Ananth, Swetha, Hotter, Dominik, Sparrer, Konstantin M J, Stürzel, Christina M, Trautz, Birthe, Ayouba, Ahidjo, Peeters, Martine, Yao, Zhong, Stagljar, Igor, Passos, Vânia, Zillinger, Thomas, Goffinet, Christine, Sauter, Daniel, Fackler, Oliver T, Kirchhoff, Frank
Published in PLoS pathogens (20.08.2018)
Published in PLoS pathogens (20.08.2018)
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Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression
Pott, Fabian, Postmus, Dylan, Brown, Richard J. P., Wyler, Emanuel, Neumann, Elena, Landthaler, Markus, Goffinet, Christine
Published in Emerging microbes & infections (01.01.2021)
Published in Emerging microbes & infections (01.01.2021)
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Antagonism of CD317 Restriction of Human Immunodeficiency Virus Type 1 (HIV-1) Particle Release and Depletion of CD317 Are Separable Activities of HIV-1 Vpu
GOFFINET, Christine, HOMANN, Stefanie, AMBIEL, Ina, TIBRONI, Nadine, RUPP, Daniel, KEPPLER, Oliver T, FACKLER, Oliver T
Published in Journal of Virology (01.04.2010)
Published in Journal of Virology (01.04.2010)
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Endogenous CD317/Tetherin Limits Replication of HIV-1 and Murine Leukemia Virus in Rodent Cells and Is Resistant to Antagonists from Primate Viruses
GOFFINET, Christine, SCHMIDT, Sarah, KERN, Christian, OBERBREMER, Lena, KEPPLER, Oliver T
Published in Journal of Virology (01.11.2010)
Published in Journal of Virology (01.11.2010)
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A realistic transfer method reveals low risk of SARS-CoV-2 transmission via contaminated euro coins and banknotes
Todt, Daniel, Meister, Toni Luise, Tamele, Barbora, Howes, John, Paulmann, Dajana, Becker, Britta, Brill, Florian H., Wind, Mark, Schijven, Jack, Heinen, Natalie, Kinast, Volker, Mhlekude, Baxolele, Goffinet, Christine, Krawczyk, Adalbert, Steinmann, Jörg, Pfaender, Stephanie, Brüggemann, Yannick, Steinmann, Eike
Published in iScience (20.08.2021)
Published in iScience (20.08.2021)
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