Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans
Salvadore, Giacomo, Bonaventure, Pascal, Shekhar, Anantha, Johnson, Philip L., Lord, Brian, Shireman, Brock T., Lebold, Terry P., Nepomuceno, Diane, Dugovic, Christine, Brooks, Sander, Zuiker, Rob, Bleys, Cathy, Tatikola, Kanaka, Remmerie, Bart, Jacobs, Gabriel E., Schruers, Koen, Moyer, John, Nash, Abigail, Van Nueten, Luc G. M., Drevets, Wayne C.
Published in Translational psychiatry (07.09.2020)
Published in Translational psychiatry (07.09.2020)
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A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects
Bonaventure, Pascal, Yun, Sujin, Johnson, Philip L, Shekhar, Anantha, Fitz, Stephanie D, Shireman, Brock T, Lebold, Terry P, Nepomuceno, Diane, Lord, Brian, Wennerholm, Michelle, Shelton, Jonathan, Carruthers, Nicholas, Lovenberg, Timothy, Dugovic, Christine
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
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Journal Article
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia
Bonaventure, Pascal, Shelton, Jonathan, Yun, Sujin, Nepomuceno, Diane, Sutton, Steven, Aluisio, Leah, Fraser, Ian, Lord, Brian, Shoblock, James, Welty, Natalie, Chaplan, Sandra R, Aguilar, Zuleima, Halter, Robin, Ndifor, Anthony, Koudriakova, Tatiana, Rizzolio, Michele, Letavic, Michael, Carruthers, Nicholas I, Lovenberg, Timothy, Dugovic, Christine
Published in The Journal of pharmacology and experimental therapeutics (01.09.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2015)
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Journal Article
Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat
Dugovic, Christine, Shelton, Jonathan E, Aluisio, Leah E, Fraser, Ian C, Jiang, Xiaohui, Sutton, Steven W, Bonaventure, Pascal, Yun, Sujin, Li, Xiaorong, Lord, Brian, Dvorak, Curt A, Carruthers, Nicholas I, Lovenberg, Timothy W
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
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Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor
Wyatt, Ryan M, Fraser, Ian, Welty, Natalie, Lord, Brian, Wennerholm, Michelle, Sutton, Steven, Ameriks, Michael K, Dugovic, Christine, Yun, Sujin, White, Allison, Nguyen, Leslie, Koudriakova, Tatiana, Tian, Gaochao, Suarez, Javier, Szewczuk, Lawrence, Bonnette, William, Ahn, Kay, Ghosh, Brahma, Flores, Christopher M, Connolly, Peter J, Zhu, Bin, Macielag, Mark J, Brandt, Michael R, Chevalier, Kristen, Zhang, Sui-Po, Lovenberg, Timothy, Bonaventure, Pascal
Published in The Journal of pharmacology and experimental therapeutics (01.03.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2020)
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Journal Article
Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation
LAPOSKY, Aaron, EASTON, Amy, DUGOVIC, Christine, WALISSER, Jacqueline, BRADFIELD, Christopher, TUREK, Fred
Published in Sleep (New York, N.Y.) (01.04.2005)
Published in Sleep (New York, N.Y.) (01.04.2005)
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Selective Blockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission, Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Induced by Citalopram in Rodents
Bonaventure, Pascal, Kelly, Lisa, Aluisio, Leah, Shelton, Jonathan, Lord, Brian, Galici, Ruggero, Miller, Kirsten, Atack, John, Lovenberg, Timothy W, Dugovic, Christine
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
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Journal Article
Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder
Bonaventure, Pascal, Dugovic, Christine, Kramer, Michelle, De Boer, Peter, Singh, Jaskaran, Wilson, Sue, Bertelsen, Kirk, Di, Jianing, Shelton, Jonathan, Aluisio, Leah, Dvorak, Lisa, Fraser, Ian, Lord, Brian, Nepomuceno, Diane, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Chai, Wenying, Dvorak, Curt, Sands, Steve, Carruthers, Nicholas, Lovenberg, Timothy W
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
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Journal Article
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation
Bonaventure, Pascal, Dugovic, Christine, Shireman, Brock, Preville, Cathy, Yun, Sujin, Lord, Brian, Nepomuceno, Diane, Wennerholm, Michelle, Lovenberg, Timothy, Carruthers, Nicolas, Fitz, Stephanie D, Shekhar, Anantha, Johnson, Philip L
Published in Frontiers in pharmacology (09.06.2017)
Published in Frontiers in pharmacology (09.06.2017)
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Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope
Berdyyeva, Tamara, Otte, Stephani, Aluisio, Leah, Ziv, Yaniv, Burns, Laurie D, Dugovic, Christine, Yun, Sujin, Ghosh, Kunal K, Schnitzer, Mark J, Lovenberg, Timothy, Bonaventure, Pascal
Published in PloS one (05.11.2014)
Published in PloS one (05.11.2014)
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Journal Article
Diurnal sex differences in the sleep-wake cycle of mice are dependent on gonadal function
PAUL, Ketema N, DUGOVIC, Christine, TUREK, Fred W, LAPOSKY, Aaron D
Published in Sleep (New York, N.Y.) (01.09.2006)
Published in Sleep (New York, N.Y.) (01.09.2006)
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Journal Article
Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice
Yun, Sujin, Wennerholm, Michelle, Shelton, Jonathan E, Bonaventure, Pascal, Letavic, Michael A, Shireman, Brock T, Lovenberg, Timothy W, Dugovic, Christine
Published in Frontiers in behavioral neuroscience (08.05.2017)
Published in Frontiers in behavioral neuroscience (08.05.2017)
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JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats
Galici, Ruggero, Rezvani, Amir H., Aluisio, Leah, Lord, Brian, Levin, Edward D., Fraser, Ian, Boggs, Jamin, Welty, Natalie, Shoblock, James R., Motley, S. Timothy, Letavic, Michael A., Carruthers, Nicholas I., Dugovic, Christine, Lovenberg, Timothy W., Bonaventure, Pascal
Published in Psychopharmacologia (01.04.2011)
Published in Psychopharmacologia (01.04.2011)
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Journal Article
Behavioral Characterization of Mice Lacking Histamine H3 Receptors
Hiroshi Toyota, Christine Dugovic, Muriel Koehl, Aaron D. Laposky, China Weber, Karen Ngo, Ying Wu, Doo Hyun Lee, Kazuhiko Yanai, Eiko Sakurai, Takehiko Watanabe, Changlu Liu, Jingcai Chen, Ann J. Barbier, Fred W. Turek, Wai-Ping Fung-Leung, Timothy W. Lovenberg
Published in Molecular pharmacology (01.08.2002)
Published in Molecular pharmacology (01.08.2002)
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Journal Article
Pharmacological characterization of JNJ-28583867, a histamine H3 receptor antagonist and serotonin reuptake inhibitor
BARBIER, Ann J, ALUISIO, Leah, PUDIAK, Cindy, DUGOVIC, Christine, SHELTON, Jonathan, MAZUR, Curt, LETAVIC, Michael A, CARRUTHERS, Nicholas I, LOVENBERG, Timothy W, LORD, Brian, YING QU, WILSON, Sandy J, BOGGS, Jamin D, BONAVENTURE, Pascal, MILLER, Kirsten, FRASER, Ian, DVORAK, Lisa
Published in European journal of pharmacology (01.12.2007)
Published in European journal of pharmacology (01.12.2007)
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Diamine-based human histamine H3 receptor antagonists: (4-Aminobutyn-1-yl)benzylamines
DVORAK, Curt A, APODACA, Richard, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, WEI XIAO, JABLONOWSKI, Jill A, BONAVENTURE, Pascal, DUGOVIC, Christine, SHELTON, Jonathan, LORD, Brian, MILLER, Kirsten, DVORAK, Lisa K
Published in European journal of medicinal chemistry (01.10.2009)
Published in European journal of medicinal chemistry (01.10.2009)
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Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8
Maher, Michael P, Wu, Nyantsz, Ravula, Suchitra, Ameriks, Michael K, Savall, Brad M, Liu, Changlu, Lord, Brian, Wyatt, Ryan M, Matta, Jose A, Dugovic, Christine, Yun, Sujin, Ver Donck, Luc, Steckler, Thomas, Wickenden, Alan D, Carruthers, Nicholas I, Lovenberg, Timothy W
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2016)
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