RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients
Venken, Koen, Jacques, Peggy, Mortier, Céline, Labadia, Mark E., Decruy, Tine, Coudenys, Julie, Hoyt, Kathleen, Wayne, Anita L., Hughes, Robert, Turner, Michael, Van Gassen, Sofie, Martens, Liesbet, Smith, Dustin, Harcken, Christian, Wahle, Joseph, Wang, Chao-Ting, Verheugen, Eveline, Schryvers, Nadia, Varkas, Gaëlle, Cypers, Heleen, Wittoek, Ruth, Piette, Yves, Gyselbrecht, Lieve, Van Calenbergh, Serge, Van den Bosch, Filip, Saeys, Yvan, Nabozny, Gerald, Elewaut, Dirk
Published in Nature communications (02.01.2019)
Published in Nature communications (02.01.2019)
Get full text
Journal Article
An RORγt Oral Inhibitor Modulates IL-17 Responses in Peripheral Blood and Intestinal Mucosa of Crohn's Disease Patients
Bassolas-Molina, Helena, Raymond, Ernest, Labadia, Mark, Wahle, Joseph, Ferrer-Picón, Elena, Panzenbeck, Mark, Zheng, Jie, Harcken, Christian, Hughes, Robert, Turner, Michael, Smith, Dustin, Calderón-Gómez, Elisabeth, Esteller, Míriam, Carrasco, Anna, Esteve, Maria, Dotti, Isabella, Corraliza, Ana Maria, Masamunt, Maria Carme, Arajol, Clàudia, Guardiola, Jordi, Ricart, Elena, Nabozny, Gerald, Salas, Azucena
Published in Frontiers in immunology (22.10.2018)
Published in Frontiers in immunology (22.10.2018)
Get full text
Journal Article
A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo
Lewis, Nuruddeen D, Patnaude, Lori A, Pelletier, Josephine, Souza, Donald J, Lukas, Susan M, King, F James, Hill, Jonathan D, Stefanopoulos, Dimitria E, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christian, Hickey, Eugene R, Modis, Louise K
Published in PloS one (26.06.2014)
Published in PloS one (26.06.2014)
Get full text
Journal Article
Nonsteroidal Dissociated Glucocorticoid Agonists Containing Azaindoles as Steroid A-Ring Mimetics
Riether, Doris, Harcken, Christian, Razavi, Hossein, Kuzmich, Daniel, Gilmore, Thomas, Bentzien, Jörg, Pack, Edward J, Souza, Donald, Nelson, Richard M, Kukulka, Alison, Fadra, Tazmeen N, Zuvela-Jelaska, Ljiljana, Pelletier, Josephine, Dinallo, Roger, Panzenbeck, Mark, Torcellini, Carol, Nabozny, Gerald H, Thomson, David S
Published in Journal of medicinal chemistry (23.09.2010)
Published in Journal of medicinal chemistry (23.09.2010)
Get full text
Journal Article
CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells
Lewis, Nuruddeen D, Muthukumarana, Akalushi, Fogal, Steven E, Corradini, Laura, Stefanopoulos, Dimitria E, Adusumalli, Prathima, Pelletier, Josephine, Panzenbeck, Mark, Berg, Karen, Canfield, Melissa, Cook, Brian N, Razavi, Hossein, Kuzmich, Daniel, Anderson, Shawn, Allard, Devan, Harrison, Paul, Grimaldi, Christine, Souza, Donald, Harcken, Christian, Fryer, Ryan M, Modis, Louise K, Brown, Maryanne L
Published in PloS one (29.08.2014)
Published in PloS one (29.08.2014)
Get full text
Journal Article
Non-steroidal dissociated glucocorticoid agonists: indoles as A-ring mimetics and function-regulating pharmacophores
Betageri, Raj, Gilmore, Thomas, Kuzmich, Daniel, Kirrane, Thomas M., Bentzien, Jörg, Wiedenmayer, Dieter, Bekkali, Younes, Regan, John, Berry, Angela, Latli, Bachir, Kukulka, Alison J., Fadra, Tazmeen N., Nelson, Richard M., Goldrick, Susan, Zuvela-Jelaska, Ljiljana, Souza, Don, Pelletier, Josephine, Dinallo, Roger, Panzenbeck, Mark, Torcellini, Carol, Lee, Heewon, Pack, Edward, Harcken, Christian, Nabozny, Gerald, Thomson, David S.
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Get full text
Journal Article
BTK inhibition ameliorates kidney disease in spontaneous lupus nephritis
Chalmers, Samantha A., Glynn, Elizabeth, Garcia, Sayra J., Panzenbeck, Mark, Pelletier, Josephine, Dimock, Janice, Seccareccia, Elise, Bosanac, Todd, Khalil, Sara, Harcken, Christian, Webb, Deborah, Nabozny, Gerald, Fine, Jay S., Souza, Donald, Klein, Elliott, Herlitz, Leal, Ramanujam, Meera, Putterman, Chaim
Published in Clinical immunology (Orlando, Fla.) (01.12.2018)
Published in Clinical immunology (Orlando, Fla.) (01.12.2018)
Get full text
Journal Article
Total Syntheses of (−)-Grandinolide and (−)-Sapranthin by the Sharpless Asymmetric Dihydroxylation of Methyltrans-3-Pentenoate: Elucidation of the Stereostructure of (−)-Sapranthin
Harcken, Christian, Brückner, Reinhard, Rank, Elisabeth
Published in Chemistry : a European journal (02.11.1998)
Published in Chemistry : a European journal (02.11.1998)
Get full text
Journal Article
Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase
Chalmers, Samantha A., Doerner, Jessica, Bosanac, Todd, Khalil, Sara, Smith, Dustin, Harcken, Christian, Dimock, Janice, Der, Evan, Herlitz, Leal, Webb, Deborah, Seccareccia, Elise, Feng, Di, Fine, Jay S., Ramanujam, Meera, Klein, Elliott, Putterman, Chaim
Published in Scientific reports (19.05.2016)
Published in Scientific reports (19.05.2016)
Get full text
Journal Article
Safety, pharmacokinetics and pharmacodynamics of BI 705564, a highly selective, covalent inhibitor of Bruton's tyrosine kinase, in Phase I clinical trials in healthy volunteers
Litzenburger, Tobias, Steffgen, Jürgen, Benediktus, Ewald, Müller, Fabian, Schultz, Armin, Klein, Elliott, Ramanujam, Meera, Harcken, Christian, Gupta, Alpana, Wu, Jing, Wiebe, Sabrina, Li, Xiujiang, Flack, Mary, Padula, Steven J., Visvanathan, Sudha, Hünnemeyer, Andreas, Hui, Jianan
Published in British journal of clinical pharmacology (01.04.2021)
Published in British journal of clinical pharmacology (01.04.2021)
Get full text
Journal Article
Selective glucocorticoid receptor modulation inhibits cytokine responses in a canine model of mild endotoxemia
Bartko, Johann, Derhaschnig, Ulla, Neels, Tania, Nabozny, Gerald H., Harcken, Christian, Leuschner, Jost, De Vries, Frerich, Jilma, Bernd
Published in Pharmacological research (01.11.2017)
Published in Pharmacological research (01.11.2017)
Get full text
Journal Article
Discovery of a Series of Pyrazinone RORγ Antagonists and Identification of the Clinical Candidate BI 730357
Harcken, Christian, Csengery, Johanna, Turner, Michael, Wu, Lifen, Liang, Shuang, Sibley, Robert, Brunette, Steven, Labadia, Mark, Hoyt, Kathleen, Wayne, Anita, Wieckowski, Thomas, Davis, Gregg, Panzenbeck, Mark, Souza, Donald, Kugler, Stanley, Terenzio, Donna, Collin, Delphine, Smith, Dustin, Fryer, Ryan M, Tseng, Yin-Chao, Hehn, Jörg P, Fletcher, Kim, Hughes, Robert O
Published in ACS medicinal chemistry letters (14.01.2021)
Published in ACS medicinal chemistry letters (14.01.2021)
Get full text
Journal Article
Discovery and optimization of pyrazole amides as antagonists of CCR1
Harcken, Christian, Sarko, Christopher, Mao, Can, Lord, John, Raudenbush, Brian, Razavi, Hossein, Liu, Pingrong, Swinamer, Alan, Disalvo, Darren, Lee, Thomas, Lin, Siqi, Kukulka, Alison, Grbic, Heather, Patel, Mita, Patel, Monica, Fletcher, Kim, Joseph, David, White, Della, Amodeo, Laura, Berg, Karen, Brown, Maryanne, Thomson, David S.
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
Get full text
Journal Article
Identification of novel azaindazole CCR1 antagonist clinical candidates
Harcken, Christian, Kuzmich, Daniel, Cook, Brain, Mao, Can, Disalvo, Darren, Razavi, Hossein, Swinamer, Alan, Liu, Pingrong, Zhang, Qiang, Kukulka, Alison, Skow, Donna, Patel, Mita, Patel, Monica, Fletcher, Kimberly, Sherry, Tara, Joseph, David, Smith, Dustin, Canfield, Melissa, Souza, Donald, Bogdanffy, Matthew, Berg, Karen, Brown, Maryanne
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
Published in Bioorganic & medicinal chemistry letters (01.02.2019)
Get full text
Journal Article
Remission induction of established nephritis by therapeutic administration of a novel BTK inhibitor in an inducible model of lupus nephritis
Chalmers, Samantha A., Doerner, Jessica L, Bosanac, Todd, Khalil, Sara, Smith, Dustin, Harcken, Christian, Dimock, Janice, Herlitz, Leal, Webb, Deborah, Seccareccia, Elise, Feng, Di, Fine, Jay S, Ramanujam, Meera, Klein, Elliott, Putterman, Chaim
Published in The Journal of immunology (1950) (01.05.2017)
Published in The Journal of immunology (1950) (01.05.2017)
Get full text
Journal Article
Identification of Highly Efficacious Glucocorticoid Receptor Agonists with a Potential for Reduced Clinical Bone Side Effects
Harcken, Christian, Riether, Doris, Kuzmich, Daniel, Liu, Pingrong, Betageri, Raj, Ralph, Mark, Emmanuel, Michel, Reeves, Jonathan T, Berry, Angela, Souza, Donald, Nelson, Richard M, Kukulka, Alison, Fadra, Tazmeen N, Zuvela-Jelaska, Ljiljana, Dinallo, Roger, Bentzien, Jörg, Nabozny, Gerald H, Thomson, David S
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
Get full text
Journal Article
Therapeutic blockade of immune complex-mediated glomerulonephritis by highly selective inhibition of Bruton’s tyrosine kinase
Chalmers, Samantha A., Doerner, Jessica L, Bosanac, Todd, Khalil, Sara, Smith, Dustin, Harcken, Christian, Dimock, Janice, Der, Evan B, Herlitz, Leal, Webb, Deborah, Seccareccia, Elise, Feng, Di, Fine, Jay S, Ramanujam, Meera, Klein, Elliott, Putterman, Chaim
Published in The Journal of immunology (1950) (01.05.2016)
Published in The Journal of immunology (1950) (01.05.2016)
Get full text
Journal Article