Genetic drug target validation using Mendelian randomisation
Schmidt, Amand F., Finan, Chris, Gordillo-Marañón, Maria, Asselbergs, Folkert W., Freitag, Daniel F., Patel, Riyaz S., Tyl, Benoît, Chopade, Sandesh, Faraway, Rupert, Zwierzyna, Magdalena, Hingorani, Aroon D.
Published in Nature communications (26.06.2020)
Published in Nature communications (26.06.2020)
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The druggable genome and support for target identification and validation in drug development
Finan, Chris, Gaulton, Anna, Kruger, Felix A, Lumbers, R Thomas, Shah, Tina, Engmann, Jorgen, Galver, Luana, Kelley, Ryan, Karlsson, Anneli, Santos, Rita, Overington, John P, Hingorani, Aroon D, Casas, Juan P
Published in Science translational medicine (29.03.2017)
Published in Science translational medicine (29.03.2017)
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Genetic architecture of host proteins involved in SARS-CoV-2 infection
Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Raffler, Johannes, Kerrison, Nicola D., Oerton, Erin, Auyeung, Victoria P. W., Luan, Jian’an, Finan, Chris, Casas, Juan P., Ostroff, Rachel, Williams, Steve A., Kastenmüller, Gabi, Ralser, Markus, Gamazon, Eric R., Wareham, Nicholas J., Hingorani, Aroon D., Langenberg, Claudia
Published in Nature communications (16.12.2020)
Published in Nature communications (16.12.2020)
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Associations Between Measures of Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Cohort Study and Mendelian Randomization Analysis Using the UK Biobank
Farmer, Ruth E, Mathur, Rohini, Schmidt, A Floriaan, Bhaskaran, Krishnan, Fatemifar, Ghazaleh, Eastwood, Sophie V, Finan, Chris, Denaxas, Spiros, Smeeth, Liam, Chaturvedi, Nish
Published in Journal of the American Heart Association (02.07.2019)
Published in Journal of the American Heart Association (02.07.2019)
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Journal Article
Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study
Dunca, Diana, Chopade, Sandesh, Gordillo-Marañón, María, Hingorani, Aroon D., Kuchenbaecker, Karoline, Finan, Chris, Schmidt, Amand F.
Published in Nature communications (21.06.2024)
Published in Nature communications (21.06.2024)
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Genetic Variants at Chromosome 9p21 and Risk of First Versus Subsequent Coronary Heart Disease Events
Patel, Riyaz S., MBBS, Asselbergs, Folkert W., MD, PhD, Quyyumi, Arshed A., MD, Palmer, Tom M., PhD, Finan, Chris I., PhD, Tragante, Vinicius, PhD, Deanfield, John, MB BChir, Hemingway, Harry, MB BChir, PhD, Hingorani, Aroon D., MBBS, PhD, Holmes, Michael V., MBBS, PhD
Published in Journal of the American College of Cardiology (03.06.2014)
Published in Journal of the American College of Cardiology (03.06.2014)
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Adiposity and grip strength: a Mendelian randomisation study in UK Biobank
Pinto Pereira, Snehal M, Garfield, Victoria, Farmaki, Aliki-Eleni, Tomlinson, David J, Norris, Thomas, Fatemifar, Ghazaleh, Denaxas, Spiros, Finan, Chris, Cooper, Rachel
Published in BMC medicine (02.06.2022)
Published in BMC medicine (02.06.2022)
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Mendelian randomization for studying the effects of perturbing drug targets
Gill, Dipender, Georgakis, Marios K., Walker, Venexia M., Schmidt, A. Floriaan, Gkatzionis, Apostolos, Freitag, Daniel F., Finan, Chris, Hingorani, Aroon D., Howson, Joanna M.M., Burgess, Stephen, Swerdlow, Daniel I., Davey Smith, George, Holmes, Michael V., Dichgans, Martin, Scott, Robert A, Zheng, Jie, Psaty, Bruce M., Davies, Neil M.
Published in Wellcome open research (2021)
Published in Wellcome open research (2021)
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LDL-C Concentrations and the 12-SNP LDL-C Score for Polygenic Hypercholesterolaemia in Self-Reported South Asian, Black and Caribbean Participants of the UK Biobank
Gratton, Jasmine, Finan, Chris, Hingorani, Aroon D, Humphries, Steve E, Futema, Marta
Published in Frontiers in genetics (31.03.2022)
Published in Frontiers in genetics (31.03.2022)
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Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups
Gebresilase, Tewodros, Finan, Chris, Suveges, Daniel, Tessema, Tesfaye Sisay, Aseffa, Abraham, Davey, Gail, Hatzikotoulas, Konstantinos, Zeggini, Eleftheria, Newport, Melanie J., Tekola-Ayele, Fasil
Published in Scientific reports (08.02.2021)
Published in Scientific reports (08.02.2021)
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Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics
Gordillo-Marañón, María, Zwierzyna, Magdalena, Charoen, Pimphen, Drenos, Fotios, Chopade, Sandesh, Shah, Tina, Engmann, Jorgen, Chaturvedi, Nishi, Papacosta, Olia, Wannamethee, Goya, Wong, Andrew, Sofat, Reecha, Kivimaki, Mika, Price, Jackie F., Hughes, Alun D., Gaunt, Tom R., Lawlor, Deborah A., Gaulton, Anna, Hingorani, Aroon D., Schmidt, Amand F., Finan, Chris
Published in Nature communications (21.10.2021)
Published in Nature communications (21.10.2021)
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Genetic Variants at Chromosome 9p21 and Risk of First Versus Subsequent Coronary Heart Disease Events: A Systematic Review and Meta-Analysis
PATEL, Riyaz S, ASSELBERGS, Folkert W, QUYYUMI, Arshed A, PALMER, Tom M, FINAN, Chris I, TRAGANTE, Vinicius, DEANFIELD, John, HEMINGWAY, Harry, HINGORANI, Aroon D, HOLMES, Michael V
Published in Journal of the American College of Cardiology (03.06.2014)
Published in Journal of the American College of Cardiology (03.06.2014)
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Journal Article
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis
Mensah-Kane, Josephine, Schmidt, Amand F, Hingorani, Aroon D, Finan, Chris, Chen, Yutang, van Duijvenboden, Stefan, Orini, Michele, Lambiase, Pier D, Tinker, Andrew, Marouli, Eirini, Munroe, Patricia B, Ramírez, Julia
Published in Frontiers in genetics (18.02.2021)
Published in Frontiers in genetics (18.02.2021)
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Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog
Hingorani, Aroon D, Gratton, Jasmine, Finan, Chris, Schmidt, A Floriaan, Patel, Riyaz, Sofat, Reecha, Kuan, Valerie, Langenberg, Claudia, Hemingway, Harry, Morris, Joan K, Wald, Nicholas J
Published in BMJ medicine (17.10.2023)
Published in BMJ medicine (17.10.2023)
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Journal Article
When drug treatments bias genetic studies: Mediation and interaction
Schmidt, Amand F, Heerspink, Hiddo J L, Denig, Petra, Finan, Chris, Groenwold, Rolf H H
Published in PloS one (28.08.2019)
Published in PloS one (28.08.2019)
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Modelling a two-stage adult population screen for autosomal dominant familial hypercholesterolaemia: cross-sectional analysis within the UK Biobank
Gratton, Jasmine, Humphries, Steve E, Schmidt, Amand Floriaan, Patel, Riyaz S, Sofat, Reecha, Finan, Chris, Morris, Joan K, Hingorani, Aroon D, Futema, Marta
Published in BMJ Public Health (01.12.2023)
Published in BMJ Public Health (01.12.2023)
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Author Correction: Genetic architecture of host proteins involved in SARS-CoV-2 infection
Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Raffler, Johannes, Kerrison, Nicola D., Oerton, Erin, Auyeung, Victoria P. W., Luan, Jian’an, Finan, Chris, Casas, Juan P., Ostroff, Rachel, Williams, Steve A., Kastenmüller, Gabi, Ralser, Markus, Gamazon, Eric R., Wareham, Nicholas J., Hingorani, Aroon D., Langenberg, Claudia
Published in Nature communications (02.02.2021)
Published in Nature communications (02.02.2021)
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The Influence of CYP2D6 and CYP2C19 Genetic Variation on Diabetes Mellitus Risk in People Taking Antidepressants and Antipsychotics
Austin-Zimmerman, Isabelle, Wronska, Marta, Wang, Baihan, Irizar, Haritz, Thygesen, Johan H, Bhat, Anjali, Denaxas, Spiros, Fatemifar, Ghazaleh, Finan, Chris, Harju-Seppänen, Jasmine, Giannakopoulou, Olga, Kuchenbaecker, Karoline, Zartaloudi, Eirini, McQuillin, Andrew, Bramon, Elvira
Published in Genes (03.11.2021)
Published in Genes (03.11.2021)
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Disease coverage of human genome-wide association studies and pharmaceutical research and development
Gordillo-Marañón, María, Schmidt, Amand F., Warwick, Alasdair, Tomlinson, Chris, Ytsma, Cai, Engmann, Jorgen, Torralbo, Ana, Maclean, Rory, Sofat, Reecha, Langenberg, Claudia, Shah, Anoop D., Denaxas, Spiros, Pirmohamed, Munir, Hemingway, Harry, Hingorani, Aroon D., Finan, Chris
Published in Communications medicine (08.10.2024)
Published in Communications medicine (08.10.2024)
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