The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Havel, Jonathan J., Chowell, Diego, Chan, Timothy A.
Published in Nature reviews. Cancer (01.03.2019)
Published in Nature reviews. Cancer (01.03.2019)
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Journal Article
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
Chowell, Diego, Morris, Luc G T, Grigg, Claud M, Weber, Jeffrey K, Samstein, Robert M, Makarov, Vladimir, Kuo, Fengshen, Kendall, Sviatoslav M, Requena, David, Riaz, Nadeem, Greenbaum, Benjamin, Carroll, James, Garon, Edward, Hyman, David M, Zehir, Ahmet, Solit, David, Berger, Michael, Zhou, Ruhong, Rizvi, Naiyer A, Chan, Timothy A
Published in Science (American Association for the Advancement of Science) (02.02.2018)
Published in Science (American Association for the Advancement of Science) (02.02.2018)
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Journal Article
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
Chowell, Diego, Krishna, Chirag, Pierini, Federica, Makarov, Vladimir, Rizvi, Naiyer A., Kuo, Fengshen, Morris, Luc G. T., Riaz, Nadeem, Lenz, Tobias L., Chan, Timothy A.
Published in Nature medicine (01.11.2019)
Published in Nature medicine (01.11.2019)
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Journal Article
Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas
Desrichard, Alexis, Kuo, Fengshen, Chowell, Diego, Lee, Ken-Wing, Riaz, Nadeem, Wong, Richard J, Chan, Timothy A, Morris, Luc G T
Published in JNCI : Journal of the National Cancer Institute (01.12.2018)
Published in JNCI : Journal of the National Cancer Institute (01.12.2018)
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Journal Article
TCR contact residue hydrophobicity is a hallmark of immunogenic CD8⁺ T cell epitopes
Chowell, Diego, Krishna, Sri, Becker, Pablo D., Cocita, Clément, Shu, Jack, Tan, Xuefang, Greenberg, Philip D., Klavinskis, Linda S., Blattman, Joseph N., Anderson, Karen S.
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (07.04.2015)
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Journal Article
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
Lu, Sydney X., De Neef, Emma, Thomas, James D., Sabio, Erich, Rousseau, Benoit, Gigoux, Mathieu, Knorr, David A., Greenbaum, Benjamin, Elhanati, Yuval, Hogg, Simon J., Chow, Andrew, Ghosh, Arnab, Xie, Abigail, Zamarin, Dmitriy, Cui, Daniel, Erickson, Caroline, Singer, Michael, Cho, Hana, Wang, Eric, Lu, Bin, Durham, Benjamin H., Shah, Harshal, Chowell, Diego, Gabel, Austin M., Shen, Yudao, Liu, Jing, Jin, Jian, Rhodes, Matthew C., Taylor, Richard E., Molina, Henrik, Wolchok, Jedd D., Merghoub, Taha, Diaz, Luis A., Abdel-Wahab, Omar, Bradley, Robert K.
Published in Cell (22.07.2021)
Published in Cell (22.07.2021)
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Journal Article
Modeling the Subclonal Evolution of Cancer Cell Populations
Chowell, Diego, Napier, James, Gupta, Rohan, Anderson, Karen S, Maley, Carlo C, Sayres, Melissa A Wilson
Published in Cancer research (Chicago, Ill.) (01.02.2018)
Published in Cancer research (Chicago, Ill.) (01.02.2018)
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Journal Article
The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland Carcinomas Differ by Subtype
Linxweiler, Maximilian, Kuo, Fengshen, Katabi, Nora, Lee, Mark, Nadeem, Zaineb, Dalin, Martin G, Makarov, Vladimir, Chowell, Diego, Dogan, Snjezana, Ganly, Ian, Hakimi, A Ari, Wong, Richard J, Riaz, Nadeem, Ho, Alan L, Chan, Timothy A, Morris, Luc G T
Published in Clinical cancer research (15.06.2020)
Published in Clinical cancer research (15.06.2020)
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Journal Article
Genetic and environmental determinants of human TCR repertoire diversity
Krishna, Chirag, Chowell, Diego, Gönen, Mithat, Elhanati, Yuval, Chan, Timothy A
Published in Immunity & ageing (04.09.2020)
Published in Immunity & ageing (04.09.2020)
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Journal Article
Autoantibody biomarkers for the detection of serous ovarian cancer
Katchman, Benjamin A, Chowell, Diego, Wallstrom, Garrick, Vitonis, Allison F, LaBaer, Joshua, Cramer, Daniel W, Anderson, Karen S
Published in Gynecologic oncology (01.07.2017)
Published in Gynecologic oncology (01.07.2017)
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Journal Article
Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma
Valero, Cristina, Golkaram, Mahdi, Vos, Joris L, Xu, Bin, Fitzgerald, Conall, Lee, Mark, Kaplan, Shannon, Han, Catherine Y, Pei, Xin, Sarkar, Reith, Boe, Lillian A, Pandey, Abhinav, Koh, Elizabeth S, Zuur, Charlotte L, Solit, David B, Pawlowski, Traci, Liu, Li, Ho, Alan L, Chowell, Diego, Riaz, Nadeem, Chan, Timothy A, Morris, Luc Gt
Published in The Journal of clinical investigation (01.10.2023)
Published in The Journal of clinical investigation (01.10.2023)
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Journal Article
526 Robust prediction of patient outcomes with immune checkpoint blockade therapy for cancer using common clinical, pathologic, and genomic features
Chang, Tiangen, Cao, Yingying, Sfreddo, Hannah, Dhruba, Saugato R, Lee, Se-Hoon, Valero, Cristina, Yoo, Seong-Keun, Chowell, Diego, Morris, Luc, Ruppin, Eytan
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab
Riaz, Nadeem, Havel, Jonathan J., Makarov, Vladimir, Desrichard, Alexis, Urba, Walter J., Sims, Jennifer S., Hodi, F. Stephen, Martín-Algarra, Salvador, Mandal, Rajarsi, Sharfman, William H., Bhatia, Shailender, Hwu, Wen-Jen, Gajewski, Thomas F., Slingluff, Craig L., Chowell, Diego, Kendall, Sviatoslav M., Chang, Han, Shah, Rachna, Kuo, Fengshen, Morris, Luc G.T., Sidhom, John-William, Schneck, Jonathan P., Horak, Christine E., Weinhold, Nils, Chan, Timothy A.
Published in Cell (02.11.2017)
Published in Cell (02.11.2017)
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Journal Article
Artificial intelligence
Gerstung, Moritz, Liu, David, Ghassemi, Marzyeh, Zou, James, Chowell, Diego, Teuwen, Jonas, Mahmood, Faisal, Kather, Jakob Nikolas
Published in Cancer cell (10.06.2024)
Published in Cancer cell (10.06.2024)
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Journal Article
Artificial intelligence
Gerstung, Moritz, Liu, David, Ghassemi, Marzyeh, Zou, James, Chowell, Diego, Teuwen, Jonas, Mahmood, Faisal, Kather, Jakob Nikolas
Published in Cancer cell (01.06.2024)
Published in Cancer cell (01.06.2024)
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Journal Article
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy
Krishna, Chirag, DiNatale, Renzo G., Kuo, Fengshen, Srivastava, Raghvendra M., Vuong, Lynda, Chowell, Diego, Gupta, Sounak, Vanderbilt, Chad, Purohit, Tanaya A., Liu, Ming, Kansler, Emily, Nixon, Briana G., Chen, Ying-Bei, Makarov, Vladimir, Blum, Kyle A., Attalla, Kyrollis, Weng, Stanley, Salmans, Michael L., Golkaram, Mahdi, Liu, Li, Zhang, Shile, Vijayaraghavan, Raakhee, Pawlowski, Traci, Reuter, Victor, Carlo, Maria I., Voss, Martin H., Coleman, Jonathan, Russo, Paul, Motzer, Robert J., Li, Ming O., Leslie, Christina S., Chan, Timothy A., Hakimi, A. Ari
Published in Cancer cell (10.05.2021)
Published in Cancer cell (10.05.2021)
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Journal Article
Improved prediction of immune checkpoint blockade efficacy across multiple cancer types
Chowell, Diego, Yoo, Seong-Keun, Valero, Cristina, Pastore, Alessandro, Krishna, Chirag, Lee, Mark, Hoen, Douglas, Shi, Hongyu, Kelly, Daniel W., Patel, Neal, Makarov, Vladimir, Ma, Xiaoxiao, Vuong, Lynda, Sabio, Erich Y., Weiss, Kate, Kuo, Fengshen, Lenz, Tobias L., Samstein, Robert M., Riaz, Nadeem, Adusumilli, Prasad S., Balachandran, Vinod P., Plitas, George, Ari Hakimi, A., Abdel-Wahab, Omar, Shoushtari, Alexander N., Postow, Michael A., Motzer, Robert J., Ladanyi, Marc, Zehir, Ahmet, Berger, Michael F., Gönen, Mithat, Morris, Luc G. T., Weinhold, Nils, Chan, Timothy A.
Published in Nature biotechnology (01.04.2022)
Published in Nature biotechnology (01.04.2022)
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Journal Article
Modelling the effect of early detection of Ebola
Chowell, Diego, Castillo-Chavez, Carlos, Krishna, Sri, Qiu, Xiangguo, Anderson, Karen S
Published in The Lancet infectious diseases (01.02.2015)
Published in The Lancet infectious diseases (01.02.2015)
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Journal Article
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors
Zapata, Luis, Caravagna, Giulio, Williams, Marc J., Lakatos, Eszter, AbdulJabbar, Khalid, Werner, Benjamin, Chowell, Diego, James, Chela, Gourmet, Lucie, Milite, Salvatore, Acar, Ahmet, Riaz, Nadeem, Chan, Timothy A., Graham, Trevor A., Sottoriva, Andrea
Published in Nature genetics (01.03.2023)
Published in Nature genetics (01.03.2023)
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