Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3
Song, Xianzhou, Chen, Jianwei, Zhao, Mingkun, Zhang, Chengwei, Yu, Yang, Lonard, David M., Chow, Dar-Chone, Palzkill, Timothy, Xu, Jianming, O’Malley, Bert W., Wang, Jin
Published in Proceedings of the National Academy of Sciences - PNAS (03.05.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (03.05.2016)
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Bufalin Is a Potent Small-Molecule Inhibitor of the Steroid Receptor Coactivators SRC-3 and SRC-1
YING WANG, LONARD, David M, HODDER, Peter, CHASE, Peter, GRIFFIN, Patrick R, SUOLING ZHOU, LAN LIAO, JIANMING XU, O'MALLEY, Bert W, YANG YU, CHOW, Dar-Chone, PALZKILL, Timothy G, JIN WANG, RUOGU QI, MATZUK, Alexander J, XIANZHOU SONG, MADOUX, Franck
Published in Cancer research (Chicago, Ill.) (01.03.2014)
Published in Cancer research (Chicago, Ill.) (01.03.2014)
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Small Molecule Inhibition of the Steroid Receptor Coactivators, SRC-3 and SRC-1
Wang, Ying, Lonard, David M, Yu, Yang, Chow, Dar-Chone, Palzkill, Timothy G, O'Malley, Bert W
Published in Molecular endocrinology (Baltimore, Md.) (01.12.2011)
Published in Molecular endocrinology (Baltimore, Md.) (01.12.2011)
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A Triple Mutant in the Ω-loop of TEM-1 β-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis
Stojanoski, Vlatko, Chow, Dar-Chone, Hu, Liya, Sankaran, Banumathi, Gilbert, Hiram F., Prasad, B. V. Venkataram, Palzkill, Timothy
Published in The Journal of biological chemistry (17.04.2015)
Published in The Journal of biological chemistry (17.04.2015)
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Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death
Wang, Lei, Yu, Yang, Chow, Dar-Chone, Yan, Fei, Hsu, Chih-Chao, Stossi, Fabio, Mancini, Michael A., Palzkill, Timothy, Liao, Lan, Zhou, Suoling, Xu, Jianming, Lonard, David M., O’Malley, Bert W.
Published in Cancer cell (10.08.2015)
Published in Cancer cell (10.08.2015)
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Structural Basis for Different Substrate Profiles of Two Closely Related Class D β‑Lactamases and Their Inhibition by Halogens
Stojanoski, Vlatko, Chow, Dar-Chone, Fryszczyn, Bartlomiej, Hu, Liya, Nordmann, Patrice, Poirel, Laurent, Sankaran, Banumathi, Prasad, B. V. Venkataram, Palzkill, Timothy
Published in Biochemistry (Easton) (02.06.2015)
Published in Biochemistry (Easton) (02.06.2015)
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Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor
Yan, Fei, Yu, Yang, Chow, Dar-Chone, Palzkill, Timothy, Madoux, Franck, Hodder, Peter, Chase, Peter, Griffin, Patrick R, O'Malley, Bert W, Lonard, David M
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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Probing the sites of interactions of rotaviral proteins involved in replication
Viskovska, Maria, Anish, Ramakrishnan, Hu, Liya, Chow, Dar-Chone, Hurwitz, Amy M, Brown, Nicholas G, Palzkill, Timothy, Estes, Mary K, Prasad, B V Venkataram
Published in Journal of virology (01.11.2014)
Published in Journal of virology (01.11.2014)
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BLIP-II Is a Highly Potent Inhibitor of Klebsiella pneumoniae Carbapenemase (KPC-2)
BROWN, Nicholas G, CHOW, Dar-Chone, PALZKILL, Timothy
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
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Co-crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding
Kim, Jeong Joo, Casteel, Darren E, Huang, Gilbert, Kwon, Taek Hun, Ren, Ronnie Kuo, Zwart, Peter, Headd, Jeffrey J, Brown, Nicholas Gene, Chow, Dar-Chone, Palzkill, Timothy, Kim, Choel
Published in PloS one (19.04.2011)
Published in PloS one (19.04.2011)
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Identification of the β-Lactamase Inhibitor Protein-II (BLIP-II) Interface Residues Essential for Binding Affinity and Specificity for Class A β-Lactamases
Brown, Nicholas G., Chow, Dar-Chone, Ruprecht, Kevin E., Palzkill, Timothy
Published in The Journal of biological chemistry (14.06.2013)
Published in The Journal of biological chemistry (14.06.2013)
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Generation and characterization of antibodies against Asian elephant (Elephas maximus) IgG, IgM, and IgA
Humphreys, Alan F, Tan, Jie, Peng, RongSheng, Benton, Susan M, Qin, Xiang, Worley, Kim C, Mikulski, Rose L, Chow, Dar-Chone, Palzkill, Timothy G, Ling, Paul D
Published in PloS one (06.02.2015)
Published in PloS one (06.02.2015)
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Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation
Krogsgaard, Michelle, Prado, Nelida, Adams, Erin J., He, Xiao-lin, Chow, Dar-Chone, Wilson, Darcy B., Garcia, K.Christopher, Davis, Mark M.
Published in Molecular cell (01.12.2003)
Published in Molecular cell (01.12.2003)
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Engineering Specificity from Broad to Narrow: Design of a β‑Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC β‑Lactamase
Chow, Dar-Chone, Rice, Kacie, Huang, Wanzhi, Atmar, Robert L, Palzkill, Timothy
Published in ACS infectious diseases (09.12.2016)
Published in ACS infectious diseases (09.12.2016)
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Analysis of the Binding Forces Driving the Tight Interactions between β-Lactamase Inhibitory Protein-II (BLIP-II) and Class A β-Lactamases
Brown, Nicholas G., Chow, Dar-Chone, Sankaran, Banumathi, Zwart, Peter, Prasad, B. V. Venkataram, Palzkill, Timothy
Published in The Journal of biological chemistry (16.09.2011)
Published in The Journal of biological chemistry (16.09.2011)
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Fine Mapping of the Sequence Requirements for Binding of β-Lactamase Inhibitory Protein (BLIP) to TEM-1 β-Lactamase Using a Genetic Screen for BLIP Function
Yuan, Ji, Huang, Wanzhi, Chow, Dar-Chone, Palzkill, Timothy
Published in Journal of molecular biology (05.06.2009)
Published in Journal of molecular biology (05.06.2009)
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