Investigation of utilization of nanosuspension formulation to enhance exposure of 1,3-dicyclohexylurea in rats: Preparation for PK/PD study via subcutaneous route of nanosuspension drug delivery
Chiang, Po-Chang, Ran, Yingqing, Chou, Kang-Jye, Cui, Yong, Wong, Harvey
Published in Nanoscale research letters (07.06.2011)
Published in Nanoscale research letters (07.06.2011)
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Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
Terrett, Jack A, Chen, Huifen, Shore, Daniel G, Villemure, Elisia, Larouche-Gauthier, Robin, Déry, Martin, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Lu, Aijun, Wang, Yunli, Cridland, Andrew P, Ward, Stuart I, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Balestrini, Alessia, Riol-Blanco, Lorena, Lee, Wyne P, Liu, John, Suto, Eric, Wu, Xiumin, Zhang, Juan, Ly, Justin Q, La, Hank, Johnson, Kevin, Baumgardner, Matt, Chou, Kang-Jye, Rohou, Alexis, Rougé, Lionel, Safina, Brian S, Magnuson, Steven, Volgraf, Matthew
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease
Terrett, Jack A., Ly, Justin Q., Katavolos, Paula, Hasselgren, Catrin, Laing, Steven, Zhong, Fiona, Villemure, Elisia, Déry, Martin, Larouche-Gauthier, Robin, Chen, Huifen, Shore, Daniel G., Lee, Wyne P., Suto, Eric, Johnson, Kevin, Brooks, Marjory, Stablein, Alyssa, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Elstrott, Justin, Gandham, Vineela, Joseph, Victory, Booler, Helen, Cain, Gary, Chou, Carolina, Fullerton, Aaron, Lepherd, Michelle, Stainton, Shannon, Torres, Elizabeth, Urban, Konnie, Yu, Lanlan, Zhong, Yu, Bao, Linda, Chou, Kang-Jye, Lin, Jessica, Zhang, Wei, La, Hank, Liu, Liling, Mulder, Teresa, Chen, Jun, Chernov-Rogan, Tania, Johnson, Adam R., Hackos, David H., Leahey, Rebecca, Shields, Shannon D., Balestrini, Alessia, Riol-Blanco, Lorena, Safina, Brian S., Volgraf, Matthew, Magnuson, Steven, Kakiuchi-Kiyota, Satoko
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor
Liederer, Bianca M., Cheong, Jonathan, Chou, Kang-Jye, Dragovich, Peter S., Le, Hoa, Liang, Xiaorong, Ly, Justin, Mukadam, Sophie, Oeh, Jason, Sampath, Deepak, Wang, Leslie, Wong, Susan
Published in Xenobiotica (02.09.2019)
Published in Xenobiotica (02.09.2019)
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Discovery of (S)‑1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl‑1H‑pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)‑one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development
Blake, James F, Burkard, Michael, Chan, Jocelyn, Chen, Huifen, Chou, Kang-Jye, Diaz, Dolores, Dudley, Danette A, Gaudino, John J, Gould, Stephen E, Grina, Jonas, Hunsaker, Thomas, Liu, Lichuan, Martinson, Matthew, Moreno, David, Mueller, Lars, Orr, Christine, Pacheco, Patricia, Qin, Ann, Rasor, Kevin, Ren, Li, Robarge, Kirk, Shahidi-Latham, Sheerin, Stults, Jeffrey, Sullivan, Francis, Wang, Weiru, Yin, Jianping, Zhou, Aihe, Belvin, Marcia, Merchant, Mark, Moffat, John, Schwarz, Jacob B
Published in Journal of medicinal chemistry (23.06.2016)
Published in Journal of medicinal chemistry (23.06.2016)
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In Vitro and In Vivo Evaluation of Amorphous Solid Dispersions Generated by Different Bench-Scale Processes, Using Griseofulvin as a Model Compound
Chiang, Po-Chang, Cui, Yong, Ran, Yingqing, Lubach, Joe, Chou, Kang-Jye, Bao, Linda, Jia, Wei, La, Hank, Hau, Jonathan, Sambrone, Amy, Qin, Ann, Deng, Yuzhong, Wong, Harvey
Published in The AAPS journal (01.04.2013)
Published in The AAPS journal (01.04.2013)
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Novel nanoparticles formulation for cassette dosing via intravenous injection in rats for high throughput pharmacokinetic screening and potential applications
Chiang, Po-Chang, Deng, Yuzhong, Ubhayaka, Savita, La, Hank, Cui, Yong, Chou, Kang-Jye, Ran, Yingqing, Wong, Harvey
Published in Journal of nanoscience and nanotechnology (01.10.2012)
Published in Journal of nanoscience and nanotechnology (01.10.2012)
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On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy
Adhikari, Pragya, Li, Guangmin, Go, MaryAnn, Mandikian, Danielle, Rafidi, Hanine, Ng, Carl, Anifa, Sagana, Johnson, Kevin, Bao, Linda, Hernandez Barry, Hilda, Rowntree, Rebecca, Agard, Nicholas, Wu, Cong, Chou, Kang-Jye, Zhang, Donglu, Kozak, Katherine R., Pillow, Thomas H., Lewis, Gail D., Yu, Shang-Fan, Boswell, C. Andrew, Sadowsky, Jack D.
Published in Journal of the American Chemical Society (17.07.2024)
Published in Journal of the American Chemical Society (17.07.2024)
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Abstract 1261: A next generation tri-complex KRASG12C(ON) inhibitor directly targets the active, GTP-bound state of mutant RAS and may overcome resistance to KRASG12C(OFF) inhibition
Nichols, Robert J., Cregg, Jim, Schulze, Christopher J., Wang, Zhican, Yang, Kevin, Jiang, Jingjing, Whalen, Daniel M., Hansen, Rich, Garrenton, Lindsay S., Bermingham, Alun, Knox, John E., Choy, Tiffany, Reyes, Denise, Rios, Mayra, Seamon, Kyle, Longhi, Michael, Chou, Kang-Jye, Li, Shaoling, Wildes, David P., Singh, Mallika, Koltun, Elena S., Gill, Adrian L., Smith, Jacqueline A. M.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 1260: First-in-class, orally bioavailable KRASG12V(ON) tri-complex inhibitors, as single agents and in combinations, drive profound anti-tumor activity in preclinical models of KRASG12V mutant cancers
Koltun, Elena, Cregg, Jim, Rice, Meghan A., Whalen, Dan M., Freilich, Rebecca, Jiang, Jingjing, Hansen, Richard, Bermingham, Alun, Knox, John E., Dinglasan, Jay, Seamon, Kyle, Blaj, Cristina, Chang, Stephanie S., Liu, Yang, Huang, Jun, Chou, Kang-Jye, McDowell, Laura, Lee, Bianca J., Wildes, David, Wang, Zhengping, Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract B137: Selective inhibition of the active state of KRASG12V with the non-covalent, tri-complex inhibitor RM-048
Lee, Bianca J, Cregg, Jim, Edwards, Anne, Chen, Jerry, Eriksson, Andre, Tonogai, Emily, Tomlinson, Aidan, Seamon, Kyle, Ayala, Mariela Moreno, Shifrin, Nataliya Tovbis, Montazer, Nilufar, Sanders, Kate, Huang, Jun, Chou, Kang-Jye, Madej, Benjamin, Liu, Yang, Wang, Zhican, Wang, Zhengping, Knox, John, Koltun, Elena, Jiang, Jingjing, Gill, Adrian, Smith, Jacqueline A.M.
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Abstract 526: RMC-9805, a first-in-class, mutant-selective, covalent and oral KRASG12D(ON) inhibitor that induces apoptosis and drives tumor regression in preclinical models of KRASG12D cancers
Jiang, Lingyan, Menard, Marie, Weller, Caroline, Wang, Zhican, Burnett, Les, Aronchik, Ida, Steele, Shelby, Flagella, Mike, Zhao, Ruiping, Evans, James W W., Chin, Shook, Chou, Kang-Jye, Mu, Yunming, Longhi, Michael, McDowell, Laura, Knox, John E., Gill, Adrian, Smith, Jacqueline A., Singh, Mallika, Quintana, Elsa, Jiang, Jingjing
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 3596: RM-036, a first-in-class, orally-bioavailable, Tri-Complex covalent KRASG12D(ON) inhibitor, drives profound anti-tumor activity in KRASG12D mutant tumor models
Knox, John E., Jiang, Jingjing, Burnett, G. Leslie, Liu, Yang, Weller, Caroline E., Wang, Zhican, McDowell, Laura, Steele, Shelby L., Chin, Shook, Chou, Kang Jye, Wang, Fang, Zhong, Mengqi, Koltun, Elena S., Wildes, David, Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 3595: RMC-6291, a next-generation tri-complex KRASG12C(ON) inhibitor, outperforms KRASG12C(OFF) inhibitors in preclinical models of KRASG12C cancers
Nichols, Robert J., Yang, Y.C., Cregg, Jim, Schulze, Chris J., Wang, Zhican, Dua, Richa, Jiang, Jingjing, Garrenton, Lindsay S., Nasholm, Nicole, Bermingham, Alun, Knox, John E., Seamon, Kyle, Longhi, Michael, Chou, Kang-Jye, Li, Shaoling, Wildes, David P., Singh, Mallika, Koltun, Elena S., Gill, Adrian L., Smith, Jacqueline A.M.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract 3598: A first-in-class tri-complex KRASG13C(ON) inhibitor validates therapeutic targeting of KRASG13Cand drives tumor regressions in preclinical models
Schulze, Christopher J., Cregg, Jim, Seamon, Kyle J., Yang, Yu Chi, Wang, Zhican, Garrenton, Lindsay S., Bermingham, Alun, Knox, John E., Tomlinson, Aidan, Chou, Kang-Jye, Li, Shaoling, Wildes, David P., Singh, Mallika, Koltun, Elena S., Gill, Adrian L., Nichols, Robert J., Smith, Jacqueline A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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