Search Results - "Choquette Deborah" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

by Hughes, Paul E, Rex, Karen, Caenepeel, Sean, Yang, Yajing, Zhang, Yihong, Broome, Martin A, Kha, Hue T, Burgess, Teresa L, Amore, Benny, Kaplan-Lefko, Paula J, Moriguchi, Jodi, Werner, Jonathan, Damore, Michael A, Baker, Daniel, Choquette, Deborah M, Harmange, Jean-Christophe, Radinsky, Robert, Kendall, Richard, Dussault, Isabelle, Coxon, Angela
Published in Molecular cancer therapeutics (01.07.2016)

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Scalable Synthesis of 6,6-Dimethylbicyclo[3.1.0]hexan-3-one

Scalable Synthesis of 6,6-Dimethylbicyclo[3.1.0]hexan-3-one

by Mennen, Steven M., Arunachalampillai, Athimoolam, Choquette, Deborah M., Muppalla, Harikrishna, Sheena, Krishna
Published in Synlett (23.10.2017)

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Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

by Peterson, Emily A, Teffera, Yohannes, Albrecht, Brian K, Bauer, David, Bellon, Steven F, Boezio, Alessandro, Boezio, Christiane, Broome, Martin A, Choquette, Deborah, Copeland, Katrina W, Dussault, Isabelle, Lewis, Richard, Lin, Min-Hwa Jasmine, Lohman, Julia, Liu, Jingzhou, Potashman, Michele, Rex, Karen, Shimanovich, Roman, Whittington, Douglas A, Vaida, Karina R, Harmange, Jean-Christophe
Published in Journal of medicinal chemistry (12.03.2015)

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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment of Cancer

by Lewis, Richard T, Bode, Christiane M, Choquette, Deborah M, Potashman, Michele, Romero, Karina, Stellwagen, John C, Teffera, Yohannes, Moore, Earl, Whittington, Douglas A, Chen, Hao, Epstein, Linda F, Emkey, Renee, Andrews, Paul S, Yu, Violeta L, Saffran, Douglas C, Xu, Man, Drew, Allison, Merkel, Patricia, Szilvassy, Steven, Brake, Rachael L
Published in Journal of medicinal chemistry (26.07.2012)

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Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase

by Albrecht, Brian K, Harmange, Jean-Christophe, Bauer, David, Berry, Loren, Bode, Christiane, Boezio, Alessandro A, Chen, April, Choquette, Deborah, Dussault, Isabelle, Fridrich, Cary, Hirai, Satoko, Hoffman, Doug, Larrow, Jay F, Kaplan-Lefko, Paula, Lin, Jasmine, Lohman, Julia, Long, Alexander M, Moriguchi, Jodi, O’Connor, Anne, Potashman, Michele H, Reese, Monica, Rex, Karen, Siegmund, Aaron, Shah, Kavita, Shimanovich, Roman, Springer, Stephanie K, Teffera, Yohannes, Yang, Yajing, Zhang, Yihong, Bellon, Steven F
Published in Journal of medicinal chemistry (22.05.2008)

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Design, Synthesis, and Evaluation of a Novel Dual Fms-Like Tyrosine Kinase 3/Stem Cell Factor Receptor (FLT3/c-KIT) Inhibitor for the Treatment of Acute Myelogenous Leukemia

Design, Synthesis, and Evaluation of a Novel Dual Fms-Like Tyrosine Kinase 3/Stem Cell Factor Receptor (FLT3/c-KIT) Inhibitor for the Treatment of Acute Myelogenous Leukemia

by Davies, Robert J, Pierce, Albert C, Forster, Cornelia, Grey, Ron, Xu, Jinwang, Arnost, Michael, Choquette, Deborah, Galullo, Vincent, Tian, Shi-Kai, Henkel, Greg, Chen, Guanjing, Heidary, David K, Ma, Joanne, Stuver-Moody, Cameron, Namchuk, Mark
Published in Journal of medicinal chemistry (27.10.2011)

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Discovery of (R)‑6-(1-(8-Fluoro-6-(1-methyl‑1H‑pyrazol-4-yl)-[1,2,4]triazolo[4,3‑a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)‑one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity

Discovery of (R)‑6-(1-(8-Fluoro-6-(1-methyl‑1H‑pyrazol-4-yl)-[1,2,4]triazolo[4,3‑a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)‑one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity

by Boezio, Alessandro A, Copeland, Katrina W, Rex, Karen, K. Albrecht, Brian, Bauer, David, Bellon, Steven F, Boezio, Christiane, Broome, Martin A, Choquette, Deborah, Coxon, Angela, Dussault, Isabelle, Hirai, Satoko, Lewis, Richard, Lin, Min-Hwa Jasmine, Lohman, Julia, Liu, Jingzhou, Peterson, Emily A, Potashman, Michele, Shimanovich, Roman, Teffera, Yohannes, Whittington, Douglas A, Vaida, Karina R, Harmange, Jean-Christophe
Published in Journal of medicinal chemistry (24.03.2016)

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Syntheses, structures, and isomerization processes of dialkylaluminum silylamido complexes

Syntheses, structures, and isomerization processes of dialkylaluminum silylamido complexes

by Choquette, Deborah M, Timm, Mary Jo, Hobbs, Jason L, Rahim, M. Marufur, Ahmed, Kazi J, Planalp, Roy P
Published in Organometallics (01.02.1992)

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Thermolysis of halo- and alkylaluminum silylamido complexes and the Al4N4 cubane core structure of [iso-BuAlNSiPh3]4

Thermolysis of halo- and alkylaluminum silylamido complexes and the Al4N4 cubane core structure of [iso-BuAlNSiPh3]4

by Choquette, Deborah M, Timm, Mary Jo, Hobbs, Jason L, Nicholson, Thomas M, Olmstead, Marilyn M, Planalp, Roy P
Published in Inorganic chemistry (01.05.1993)

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Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: Design, synthesis, and evaluations

Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: Design, synthesis, and evaluations

by Harmange, Jean-Christophe, Weiss, Matthew M., Germain, Julie, Polverino, Anthony J., Borg, George, Bready, James, Chen, Danlin, Choquette, Deborah, Coxon, Angela, DeMelfi, Tom, DiPietro, Lucian, Doerr, Nicholas, Estrada, Juan, Flynn, Julie, Graceffa, Russell F., Harriman, Shawn P., Kaufman, Stephen, La, Daniel S., Long, Alexander, Martin, Matthew W., Neervannan, Sesha, Patel, Vinod F., Potashman, Michele, Regal, Kelly, Roveto, Phillip M., Schrag, Michael L., Starnes, Charlie, Tasker, Andrew, Teffera, Yohannes, Wang, Ling, White, Ryan D., Whittington, Douglas A., Zanon, Roger
Published in Journal of medicinal chemistry (27.03.2008)

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Abstract 728: AMG 337, a novel, potent and selective MET kinase inhibitor, has robust growth inhibitory activity in MET-dependent cancer models

Abstract 728: AMG 337, a novel, potent and selective MET kinase inhibitor, has robust growth inhibitory activity in MET-dependent cancer models

by Hughes, Paul E., Yang, Yajing, Rex, Karen, Zhang, Yihong, Kaplan-Lefko, Paula J., Caenepeel, Sean, Moriguchi, Jodi, Broome, Martin, Choquette, Deborah, Radinsky, Robert, Kendall, Richard, Coxon, Angela, Dussault, Isabelle
Published in Cancer research (Chicago, Ill.) (01.10.2014)

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Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors

by Peterson, Emily A., Boezio, Alessandro A., Andrews, Paul S., Boezio, Christiane M., Bush, Tammy L., Cheng, Alan C., Choquette, Deborah, Coats, James R., Colletti, Adria E., Copeland, Katrina W., DuPont, Michelle, Graceffa, Russell, Grubinska, Barbara, Kim, Joseph L., Lewis, Richard T., Liu, Jingzhou, Mullady, Erin L., Potashman, Michele H., Romero, Karina, Shaffer, Paul L., Stanton, Mary K., Stellwagen, John C., Teffera, Yohannes, Yi, Shuyan, Cai, Ti, La, Daniel S.
Published in Bioorganic & medicinal chemistry letters (01.08.2012)

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Discovery of novel 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydroisoquinoline-1(2 H)-ones as potent and selective inhibitors of KDR: Synthesis, SAR, and pharmacokinetic properties

Discovery of novel 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydroisoquinoline-1(2 H)-ones as potent and selective inhibitors of KDR: Synthesis, SAR, and pharmacokinetic properties

by Choquette, Deborah, Teffera, Yohannes, Polverino, Anthony, Harmange, Jean-Christophe
Published in Bioorganic & medicinal chemistry letters (15.07.2008)

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Correction to Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

Correction to Discovery of Potent and Selective 8‑Fluorotriazolopyridine c‑Met Inhibitors

by Peterson, Emily A, Teffera, Yohannes, Albrecht, Brian K, Bauer, David, Bellon, Steven F, Boezio, Alessandro, Boezio, Christiane, Broome, Martin A, Choquette, Deborah, Copeland, Katrina W, Dussault, Isabelle, Lewis, Richard, Lin, Min-Hwa Jasmine, Lohman, Julia, Liu, Jingzhou, Potashman, Michele, Rex, Karen, Shimanovich, Roman, Whittington, Douglas A, Vaida, Karina R, Harmange, Jean-Christophe
Published in Journal of medicinal chemistry (14.05.2015)

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Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors

Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors

by Boezio, Alessandro A., Berry, Loren, Albrecht, Brian K., Bauer, David, Bellon, Steven F., Bode, Christiane, Chen, April, Choquette, Deborah, Dussault, Isabelle, Hirai, Satoko, Kaplan-Lefko, Paula, Larrow, Jay F., Lin, Min-Hwa Jasmine, Lohman, Julia, Potashman, Michele H., Rex, Karen, Santostefano, Michael, Shah, Kavita, Shimanovich, Roman, Springer, Stephanie K., Teffera, Yohannes, Yang, Yajing, Zhang, Yihong, Harmange, Jean-Christophe
Published in Bioorganic & medicinal chemistry letters (15.11.2009)

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Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors

Discovery and optimization of a potent and selective triazolopyridinone series of c-Met inhibitors

by Bode, Christiane M., Boezio, Alessandro A., Albrecht, Brian K., Bellon, Steven F., Berry, Loren, Broome, Martin A., Choquette, Deborah, Dussault, Isabelle, Lewis, Richard T., Lin, Min-Hwa Jasmine, Rex, Karen, Whittington, Douglas A., Yang, Yajing, Harmange, Jean-Christophe
Published in Bioorganic & medicinal chemistry letters (15.06.2012)

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VX-322: A Novel Dual Receptor Tyrosine Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia

VX-322: A Novel Dual Receptor Tyrosine Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia

by Heidary, David K, Huang, George, Boucher, Diane, Ma, Jianguo, Forster, Cornelia, Grey, Ron, Xu, Jinwang, Arnost, Michael, Choquette, Deborah, Chen, Guanjing, Zhou, Jie-Hua, Yao, Yung-Mae, Ball, Edward D, Namchuk, Mark, Davies, Robert J, Henkel, Greg
Published in Journal of medicinal chemistry (26.01.2012)

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Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation

Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation

by Harmange, Jean-Christophe, Weiss, Matthew M, Germain, Julie, Polverino, Anthony J, Borg, George, Bready, James, Chen, Danlin, Choquette, Deborah, Coxon, Angela, DeMelfi, Tom, DiPietro, Lucian, Doerr, Nicholas, Estrada, Juan, Flynn, Julie, Graceffa, Russell F, Harriman, Shawn P, Kaufman, Stephen, La, Daniel S, Long, Alexander, Martin, Matthew W, Neervannan, Sesha, Patel, Vinod F, Potashman, Michele, Regal, Kelly, Roveto, Phillip M, Schrag, Michael L, Starnes, Charlie, Tasker, Andrew, Teffera, Yohannes, Wang, Ling, White, Ryan D, Whittington, Douglas A, Zanon, Roger
Published in Journal of medicinal chemistry (27.03.2008)

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Synthesis, structure, and alcoholysis of .eta.5-1,3-bis(trimethylsilyl)cyclopentadienyltitanium cis-1,3,5-cyclohexanetrialkoxide, an adamantane-framework complex of a polydentate alkoxide ligand

Synthesis, structure, and alcoholysis of .eta.5-1,3-bis(trimethylsilyl)cyclopentadienyltitanium cis-1,3,5-cyclohexanetrialkoxide, an adamantane-framework complex of a polydentate alkoxide ligand

by Choquette, Deborah M, Buschmann, Wayne E, Olmstead, Marilyn M, Planalp, Roy P
Published in Inorganic chemistry (01.03.1993)

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Bioactivation of Isothiazoles: Minimizing the Risk of Potential Toxicity in Drug Discovery

Bioactivation of Isothiazoles: Minimizing the Risk of Potential Toxicity in Drug Discovery

by Teffera, Yohannes, Choquette, Deborah, Liu, Jingzhou, Colletti, Adria E, Hollis, L. Steven, Lin, Min-Hwa Jasmine, Zhao, Zhiyang
Published in Chemical research in toxicology (15.11.2010)

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