Inhibition of the Interleukin-36 Pathway for the Treatment of Generalized Pustular Psoriasis
Bachelez, Hervé, Choon, Siew-Eng, Marrakchi, Slaheddine, Burden, A. David, Tsai, Tsen-Fang, Morita, Akimichi, Turki, Hamida, Hall, David B, Shear, Michael, Baum, Patrick, Padula, Steven J, Thoma, Christian
Published in The New England journal of medicine (07.03.2019)
Published in The New England journal of medicine (07.03.2019)
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Trial of Spesolimab for Generalized Pustular Psoriasis
Bachelez, Hervé, Choon, Siew-Eng, Marrakchi, Slaheddine, Burden, A. David, Tsai, Tsen-Fang, Morita, Akimichi, Navarini, Alexander A, Zheng, Min, Xu, Jinhua, Turki, Hamida, Anadkat, Milan J, Rajeswari, Sushmita, Hua, Hairui, Vulcu, Sebastian D, Hall, David, Tetzlaff, Kay, Thoma, Christian, Lebwohl, Mark G
Published in The New England journal of medicine (23.12.2021)
Published in The New England journal of medicine (23.12.2021)
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Clinical and genetic differences between pustular psoriasis subtypes
Twelves, Sophie, Mostafa, Alshimaa, Dand, Nick, Burri, Elias, Farkas, Katalin, Wilson, Rosemary, Cooper, Hywel L., Irvine, Alan D., Oon, Hazel H., Kingo, Külli, Köks, Sulev, Mrowietz, Ulrich, Puig, Luis, Reynolds, Nick, Tan, Eugene Sern-Ting, Tanew, Adrian, Torz, Kaspar, Trattner, Hannes, Valentine, Mark, Wahie, Shyamal, Warren, Richard B., Wright, Andrew, Bata-Csörgő, Zsuzsa, Szell, Marta, Griffiths, Christopher E.M., Burden, A. David, Choon, Siew-Eng, Smith, Catherine H., Barker, Jonathan N., Navarini, Alexander A., Capon, Francesca
Published in Journal of allergy and clinical immunology (01.03.2019)
Published in Journal of allergy and clinical immunology (01.03.2019)
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Whole genome sequencing identifies genetic variants associated with co-trimoxazole hypersensitivity in Asians
Wang, Chuang-Wei, Tassaneeyakul, Wichittra, Chen, Chun-Bing, Chen, Wei-Ti, Teng, Yu-Chuan, Huang, Cheng-Yang, Sukasem, Chonlaphat, Lu, Chun-Wei, Lee, Yun-Shien, Choon, Siew-Eng, Nakkam, Nontaya, Hui, Rosaline Chung-Yee, Huang, Yen-Hua, Chang, Ya-Ching, Lin, Yang Yu-Wei, Chang, Chee-Jen, Chiu, Tsu-Man, Chantratita, Wasun, Konyoung, Parinya, Lee, Chaw-Ning, Klaewsongkram, Jettanong, Rerkpattanapipat, Ticha, Amornpinyo, Warayuwadee, Saksit, Niwat, Rerknimitr, Pawinee, Huang, Yu Huei, Lin, Shang-Hung, Hsu, Chao-Kai, Chan, Cheng-Chi, Lin, Yu-Jr, Hung, Shuen-Iu, Chung, Wen-Hung
Published in Journal of allergy and clinical immunology (01.04.2021)
Published in Journal of allergy and clinical immunology (01.04.2021)
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AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production
Mahil, Satveer K., Twelves, Sophie, Farkas, Katalin, Setta-Kaffetzi, Niovi, Burden, A. David, Gach, Joanna E., Irvine, Alan D., Képíró, László, Mockenhaupt, Maja, Oon, Hazel H., Pinner, Jason, Ranki, Annamari, Seyger, Marieke M.B., Soler-Palacin, Pere, Storan, Eoin R., Tan, Eugene S., Valeyrie-Allanore, Laurence, Young, Helen S., Trembath, Richard C., Choon, Siew-Eng, Szell, Marta, Bata-Csorgo, Zsuzsanna, Smith, Catherine H., Di Meglio, Paola, Barker, Jonathan N., Capon, Francesca
Published in Journal of investigative dermatology (01.11.2016)
Published in Journal of investigative dermatology (01.11.2016)
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Efficacy and safety of spesolimab in Asian patients with a generalized pustular psoriasis flare: Results from the randomized, double‐blind, placebo‐controlled Effisayil™ 1 study
Morita, Akimichi, Tsai, Tsen‐Fang, Yee, Evelyn Yap Wen, Okubo, Yukari, Imafuku, Shinichi, Zheng, Min, Li, Ling, Quaresma, Manuel, Thoma, Christian, Choon, Siew Eng
Published in Journal of dermatology (01.02.2023)
Published in Journal of dermatology (01.02.2023)
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Journal Article
Rare Pathogenic Variants in IL36RN Underlie a Spectrum of Psoriasis-Associated Pustular Phenotypes
Setta-Kaffetzi, Niovi, Navarini, Alexander A., Patel, Varsha M., Pullabhatla, Venu, Pink, Andrew E., Choon, Siew-Eng, Allen, Michael A., Burden, A David, Griffiths, Christopher E.M., Seyger, Marieke M.B., Kirby, Brian, Trembath, Richard C., Simpson, Michael A., Smith, Catherine H., Capon, Francesca, Barker, Jonathan N.
Published in Journal of investigative dermatology (01.05.2013)
Published in Journal of investigative dermatology (01.05.2013)
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Juvenile generalized pustular psoriasis is a chronic recalcitrant disease: an analysis of 27 patients seen in a tertiary hospital in Johor, Malaysia
Lau, Bi‐Wen, Lim, Dee‐Zhen, Capon, Francesca, Barker, Jonathan N., Choon, Siew‐Eng
Published in International journal of dermatology (01.04.2017)
Published in International journal of dermatology (01.04.2017)
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Understanding generalized pustular psoriasis for improved patient care
Choon, Siew Eng, Barker, Jonathan, Bachelez, Herve
Published in Experimental dermatology (01.08.2023)
Published in Experimental dermatology (01.08.2023)
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The MARCOPOLO Study of Ustekinumab Utilization and Efficacy in a Real-World Setting: Treatment of Patients with Plaque Psoriasis in Asia-Pacific Countries
Youn, Sang Woong, Tsai, Tsen-Fang, Theng, Colin, Choon, Siew-Eng, Wiryadi, Benny E, Pires, Antonio, Tan, Weihao, Lee, Min-Geol
Published in Annals of dermatology (01.04.2016)
Published in Annals of dermatology (01.04.2016)
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Efficacy and safety of subcutaneous spesolimab for the prevention of generalised pustular psoriasis flares (Effisayil 2): an international, multicentre, randomised, placebo-controlled trial
Morita, Akimichi, Strober, Bruce, Burden, A David, Choon, Siew Eng, Anadkat, Milan J, Marrakchi, Slaheddine, Tsai, Tsen-Fang, Gordon, Kenneth B, Thaçi, Diamant, Zheng, Min, Hu, Na, Haeufel, Thomas, Thoma, Christian, Lebwohl, Mark G
Published in The Lancet (British edition) (28.10.2023)
Published in The Lancet (British edition) (28.10.2023)
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IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis
Catapano, Marika, Vergnano, Marta, Romano, Marco, Mahil, Satveer K., Choon, Siew-Eng, Burden, A. David, Young, Helen S., Carr, Ian M., Lachmann, Helen J., Lombardi, Giovanna, Smith, Catherine H., Ciccarelli, Francesca D., Barker, Jonathan N., Capon, Francesca
Published in Journal of investigative dermatology (01.04.2020)
Published in Journal of investigative dermatology (01.04.2020)
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Loss-of-Function Myeloperoxidase Mutations Are Associated with Increased Neutrophil Counts and Pustular Skin Disease
Vergnano, Marta, Mockenhaupt, Maja, Benzian-Olsson, Natashia, Paulmann, Maren, Grys, Katarzyna, Mahil, Satveer K., Chaloner, Charlotte, Barbosa, Ines A., August, Suzannah, Burden, A. David, Choon, Siew-Eng, Cooper, Hywel, Navarini, Alex A., Reynolds, Nick J., Wahie, Shyamal, Warren, Richard B., Wright, Andrew, Abraham, Thamir, Ali, Mahmud, August, Suzannah, Baudry, David, Bewley, Anthony, Cooper, Hywel, Griffiths, Christopher E.M., Ingram, John, Kelly, Susan, Korshid, Mohsen, Ladoyanni, Effie, McKenna, John, Meynell, Freya, Parslew, Richard, Patel, Prakash, Pushparajah, Angela, Reynolds, Nick, Smith, Catherine, Wahie, Shyamal, Warren, Richard, Wright, Andrew, Huffmeier, Ulrike, Baum, Patrick, Visvanathan, Sudha, Barker, Jonathan N., Smith, Catherine H., Capon, Francesca
Published in American journal of human genetics (03.09.2020)
Published in American journal of human genetics (03.09.2020)
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Journal Article
Clinical profile, morbidity, and outcome of adult-onset generalized pustular psoriasis: analysis of 102 cases seen in a tertiary hospital in Johor, Malaysia
Choon, Siew Eng, Lai, Nai Ming, Mohammad, Norshaleyna A, Nanu, Nalini M, Tey, Kwee Eng, Chew, Shang Fern
Published in International journal of dermatology (01.06.2014)
Published in International journal of dermatology (01.06.2014)
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Journal Article
Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi‐ethnic Johor Bahru, Malaysia
Choon, Siew Eng, Tok, Peter Seah Keng, Wong, Kit Wan, Lim, Yee Ting, Nanu, Nalini M., Barker, Jonathan N., Capon, Francesca
Published in Experimental dermatology (01.08.2023)
Published in Experimental dermatology (01.08.2023)
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Genetic Variants Associated With Phenytoin-Related Severe Cutaneous Adverse Reactions
Chung, Wen-Hung, Chang, Wan-Chun, Lee, Yun-Shien, Wu, Ying-Ying, Yang, Chih-Hsun, Ho, Hsin-Chun, Chen, Ming-Jing, Lin, Jing-Yi, Hui, Rosaline Chung-Yee, Ho, Ji-Chen, Wu, Wei-Ming, Chen, Ting-Jui, Wu, Tony, Wu, Yih-Ru, Hsih, Mo-Song, Tu, Po-Hsun, Chang, Chen-Nen, Hsu, Chien-Ning, Wu, Tsu-Lan, Choon, Siew-Eng, Hsu, Chao-Kai, Chen, Der-Yuan, Liu, Chin-San, Lin, Ching-Yuang, Kaniwa, Nahoko, Saito, Yoshiro, Takahashi, Yukitoshi, Nakamura, Ryosuke, Azukizawa, Hiroaki, Shi, Yongyong, Wang, Tzu-Hao, Chuang, Shiow-Shuh, Tsai, Shih-Feng, Chang, Chee-Jen, Chang, Yu-Sun, Hung, Shuen-Iu
Published in JAMA : the journal of the American Medical Association (06.08.2014)
Published in JAMA : the journal of the American Medical Association (06.08.2014)
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The Function of HLA-B13:01 Involved in the Pathomechanism of Dapsone-Induced Severe Cutaneous Adverse Reactions
Chen, Wei-Ti, Wang, Chuang-Wei, Lu, Chun-Wei, Chen, Chun-Bing, Lee, Hua-En, Hung, Shuen-Iu, Choon, Siew-Eng, Yang, Chih-Hsun, Liu, Ming-Tsan, Chen, Ting Jui, Fan, Wen-Lang, Su, Shih-Chi, Lin, Yang Yu-Wei, Chang, Ya-Ching, Chung, Wen-Hung
Published in Journal of investigative dermatology (01.07.2018)
Published in Journal of investigative dermatology (01.07.2018)
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Study protocol of the global Effisayil 1 Phase II, multicentre, randomised, double-blind, placebo-controlled trial of spesolimab in patients with generalized pustular psoriasis presenting with an acute flare
Choon, Siew Eng, Lebwohl, Mark G, Marrakchi, Slaheddine, Burden, A David, Tsai, Tsen-Fang, Morita, Akimichi, Navarini, Alexander A, Zheng, Min, Xu, Jinhua, Turki, Hamida, Rajeswari, Sushmita, Deng, Hongjie, Tetzlaff, Kay, Thoma, Christian, Bachelez, Hervé
Published in BMJ open (30.03.2021)
Published in BMJ open (30.03.2021)
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Journal Article
AP1S3 Mutations Are Associated with Pustular Psoriasis and Impaired Toll-like Receptor 3 Trafficking
Setta-Kaffetzi, Niovi, Simpson, Michael A., Navarini, Alexander A., Patel, Varsha M., Lu, Hui-Chun, Allen, Michael H., Duckworth, Michael, Bachelez, Hervé, Burden, A. David, Choon, Siew-Eng, Griffiths, Christopher E.M., Kirby, Brian, Kolios, Antonios, Seyger, Marieke M.B., Prins, Christa, Smahi, Asma, Trembath, Richard C., Fraternali, Franca, Smith, Catherine H., Barker, Jonathan N., Capon, Francesca
Published in American journal of human genetics (01.05.2014)
Published in American journal of human genetics (01.05.2014)
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