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Role of P‑Glycoprotein on the Brain Penetration and Brain Pharmacodynamic Activity of the MEK Inhibitor Cobimetinib
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Published in Molecular pharmaceutics (03.11.2014)
Published in Molecular pharmaceutics (03.11.2014)
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Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic-Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK Inhibitor
WONG, Harvey, VERNILLET, Laurent, HOEFLICH, Klaus P, YONGCHANG SHI, AFTAB, Blake T, AOYAMA, Ron, TAN LAM, Sanh, BELVIN, Marcia, PRESCOTT, John, PETERSON, Amy, WARE, Joseph A, LEE, Lillian, MARTINI, Jean-Francois, PEIWEN YU, CONGFEN LI, DEL ROSARIO, Geoffrey, CHOO, Edna F
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Published in Clinical cancer research (01.06.2012)
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A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors
Bronner, Sarah M, Murray, Jeremy, Romero, F. Anthony, Lai, Kwong Wah, Tsui, Vickie, Cyr, Patrick, Beresini, Maureen H, de leon Boenig, Gladys, Chen, Zhongguo, Choo, Edna F, Clark, Kevin R, Crawford, Terry D, Jayaram, Hariharan, Kaufman, Susan, Li, Ruina, Li, Yingjie, Liao, Jiangpeng, Liang, Xiaorong, Liu, Wenfeng, Ly, Justin, Maher, Jonathan, Wai, John, Wang, Fei, Zheng, Aijun, Zhu, Xiaoyu, Magnuson, Steven
Published in Journal of medicinal chemistry (28.12.2017)
Published in Journal of medicinal chemistry (28.12.2017)
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Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions
Choo, Edna F, Belvin, Marcia, Boggs, Jason, Deng, Yuzhong, Hoeflich, Klaus P, Ly, Justin, Merchant, Mark, Orr, Christine, Plise, Emile, Robarge, Kirk, Martini, Jean F, Kassees, Robert, Aoyama, Ron G, Ramaiya, Atulkumar, Johnston, Stuart H
Published in Drug metabolism and disposition (01.05.2012)
Published in Drug metabolism and disposition (01.05.2012)
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Differential in Vivo Sensitivity to Inhibition of P-glycoprotein Located in Lymphocytes, Testes, and the Blood-Brain Barrier
Choo, Edna F, Kurnik, Daniel, Muszkat, Mordechai, Ohkubo, Tadashi, Shay, Sheila D, Higginbotham, James N, Glaeser, Hartmut, Kim, Richard B, Wood, Alastair J J, Wilkinson, Grant R
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2006)
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Identification of a Discrete Diglucuronide of GDC-0810 in Human Plasma after Oral Administration
Zhang, Chenghong, Su, Dian, Choo, Edna F, Liu, Lichuan, Bobba, Sudheer, Jorski, Jamie, Ho, Quynh, Wang, Jing, Kenny, Jane, Khojasteh, S Cyrus, Zhang, Donglu
Published in Drug metabolism and disposition (01.10.2023)
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GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
Romero, F. Anthony, Murray, Jeremy, Lai, Kwong Wah, Tsui, Vickie, Albrecht, Brian K, An, Le, Beresini, Maureen H, de Leon Boenig, Gladys, Bronner, Sarah M, Chan, Emily W, Chen, Kevin X, Chen, Zhongguo, Choo, Edna F, Clagg, Kyle, Clark, Kevin, Crawford, Terry D, Cyr, Patrick, de Almeida Nagata, Denise, Gascoigne, Karen E, Grogan, Jane L, Hatzivassiliou, Georgia, Huang, Wei, Hunsaker, Thomas L, Kaufman, Susan, Koenig, Stefan G, Li, Ruina, Li, Yingjie, Liang, Xiaorong, Liao, Jiangpeng, Liu, Wenfeng, Ly, Justin, Maher, Jonathan, Masui, Colin, Merchant, Mark, Ran, Yingqing, Taylor, Alexander M, Wai, John, Wang, Fei, Wei, Xiaocang, Yu, Dong, Zhu, Bing-Yan, Zhu, Xiaoyu, Magnuson, Steven
Published in Journal of medicinal chemistry (22.11.2017)
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Bioactivation of α , β -Unsaturated Carboxylic Acids Through Acyl Glucuronidation
Mulder, Teresa, Bobba, Sudheer, Johnson, Kevin, Grandner, Jessica M., Wang, Wei, Zhang, Chenghong, Cai, Jingwei, Choo, Edna F., Khojasteh, S. Cyrus, Zhang, Donglu
Published in Drug metabolism and disposition (01.09.2020)
Published in Drug metabolism and disposition (01.09.2020)
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Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response
WONG, Harvey, CHOO, Edna F, GOULD, Stephen E, ALICKE, Bruno, XIAO DING, LA, Hank, MCNAMARA, Erin, THEIL, Frank-Peter, TIBBITTS, Jay, FRIEDMAN, Lori S, HOP, Cornelis E. C. A
Published in Clinical cancer research (15.07.2012)
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Role of Transporters in the Disposition of the Selective Phosphodiesterase-4 Inhibitor (+)-2-[4-({[2-(Benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic Acid in Rat and Human
KALGUTKAR, Amit S, BO FENG, DUIGNAN, David B, CHOO, Edna F, ZHAO, Sabrina X, NGUYEN, Hang T, FREDERICK, Kosea S, CAMPBELL, Scott D, HATCH, Heather L, BI, Yi-An, KAZOLIAS, Diana C, DAVIDSON, Ralph E, MIRELES, Rouchelle J
Published in Drug metabolism and disposition (01.11.2007)
Published in Drug metabolism and disposition (01.11.2007)
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Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors
Bryan, Marian C, Drobnick, Joy, Gobbi, Alberto, Kolesnikov, Aleksandr, Chen, Yongsheng, Rajapaksa, Naomi, Ndubaku, Chudi, Feng, Jianwen, Chang, Willy, Francis, Ross, Yu, Christine, Choo, Edna F, DeMent, Kevin, Ran, Yingqing, An, Le, Emson, Claire, Huang, Zhiyu, Sujatha-Bhaskar, Swathi, Brightbill, Hans, DiPasquale, Antonio, Maher, Jonathan, Wai, John, McKenzie, Brent S, Lupardus, Patrick J, Zarrin, Ali A, Kiefer, James R
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Published in Journal of medicinal chemistry (11.07.2019)
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Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor
Choo, Edna F, Woolsey, Sarah, DeMent, Kevin, Ly, Justin, Messick, Kirsten, Qin, Ann, Takahashi, Ryan
Published in Drug metabolism and disposition (01.06.2015)
Published in Drug metabolism and disposition (01.06.2015)
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Preclinical Safety Assessment of a Highly Selective and Potent Dual Small-Molecule Inhibitor of CBP/P300 in Rats and Dogs
Katavolos, Paula, Cain, Gary, Farman, Cindy, Romero, F Anthony, Magnuson, Steven, Ly, Justin Q, Choo, Edna F, Katakam, Anand Kumar, Andaya, Roxanne, Maher, Jonathan
Published in Toxicologic pathology (01.04.2020)
Published in Toxicologic pathology (01.04.2020)
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The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199
Choo, Edna F, Boggs, Jason, Zhu, Chunqiang, Lubach, Joseph W, Catron, Nathaniel D, Jenkins, Gary, Souers, Andrew J, Voorman, Richard
Published in Drug metabolism and disposition (01.02.2014)
Published in Drug metabolism and disposition (01.02.2014)
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Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1
Tellis, John C, Wei, BinQing, Siu, Michael, An, Le, Chan, Grace Kayan, Chen, Yong, Du, Xiangnan, Gazzard, Lewis, Hu, Baihua, Kiefer, James, Kakiuchi-Kiyota, Satoko, Lainchbury, Michael, Linehan, Jonathan L, Luo, Xifeng, Malhotra, Sushant, Mendonca, Rohan, Pang, Jodie, Ran, Yinqing, Sethuraman, Vijay, Seward, Eileen, Sneeringer, Chris, Su, Dian, Wang, Weiru, Wu, Ping, Moffat, John G, Heffron, Timothy P, Choo, Edna F, Chan, Bryan K
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
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