Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester
Shang, Jackie, Tschirret-Guth, Richard, Cancilla, Mark, Samuel, Koppara, Chen, Qing, Chobanian, Harry R, Thomas, Ann, Tong, Wei, Josien, Hubert, Buevich, Alexei V, Mitra, Kaushik
Published in Chemical research in toxicology (21.01.2020)
Published in Chemical research in toxicology (21.01.2020)
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Driving to a Better Understanding of Acyl Glucuronide Transformations Using NMR and Molecular Modeling
Buevich, Alexei V, He, Cyndi Qixin, Pio, Barbara, Samuel, Koppara, Mitra, Kaushik, Sherer, Edward C, Cancilla, Mark T, Chobanian, Harry R
Published in Chemical research in toxicology (21.03.2022)
Published in Chemical research in toxicology (21.03.2022)
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Differentiation of Deprotonated Acyl‑, N‑, and O‑Glucuronide Drug Metabolites by Using Tandem Mass Spectrometry Based on Gas-Phase Ion–Molecule Reactions Followed by Collision-Activated Dissociation
Niyonsaba, Edouard, Easton, McKay W, Feng, Erlu, Yu, Zaikuan, Zhang, Zhoupeng, Sheng, Huaming, Kong, John, Easterling, Leah F, Milton, Jacob, Chobanian, Harry R, Deprez, Nicholas R, Cancilla, Mark T, Kilaz, Gozdem, Kenttämaa, Hilkka I
Published in Analytical chemistry (Washington) (03.09.2019)
Published in Analytical chemistry (Washington) (03.09.2019)
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Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic
Jiang, Jinlong, Ding, Fa-Xiang, Zhou, Xiaoyan, Bateman, Thomas J, Dong, Shuzhi, Gu, Xin, Keh deJesus, Reynalda, Pio, Barbara, Tang, Haifeng, Chobanian, Harry R, Levorse, Dorothy, Hu, Mengwei, Thomas-Fowlkes, Brande, Margulis, Michael, Koehler, Martin, Weinglass, Adam, Gibson, Jack, Houle, Kevin, Yudkovitz, Joel, Hampton, Caryn, Pai, Lee-Yuh, Samuel, Koppara, Cutarelli, Timothy, Sullivan, Kathleen, Parmee, Emma R, Davies, Ian, Pasternak, Alexander
Published in Journal of medicinal chemistry (10.06.2021)
Published in Journal of medicinal chemistry (10.06.2021)
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A Modular Synthesis of 2-Alkyl- and 2-Arylchromans via a Three-Step Sequence
Orr, Robert K., Campeau, Louis-Charles, Chobanian, Harry R., Dunn, Jamie M. McCabe, Pio, Barbara, Plummer, Christopher W., Nolting, Andrew, Ruck, Rebecca T.
Published in Synthesis (Stuttgart) (01.02.2017)
Published in Synthesis (Stuttgart) (01.02.2017)
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GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent
Pachanski, Michele J, Kirkland, Melissa E, Kosinski, Daniel T, Mane, Joel, Cheewatrakoolpong, Boonlert, Xue, Jiyan, Szeto, Daphne, Forrest, Gail, Miller, Corin, Bunzel, Michelle, Plummer, Christopher W, Chobanian, Harry R, Miller, Michael W, Souza, Sarah, Thomas-Fowlkes, Brande S, Ogawa, Aimie M, Weinglass, Adam B, Di Salvo, Jerry, Li, Xiaoyan, Feng, Yue, Tatosian, Daniel A, Howard, Andrew D, Colletti, Steven L, Trujillo, Maria E
Published in PloS one (20.10.2017)
Published in PloS one (20.10.2017)
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From Functional Fatty Acids to Potent and Selective Natural-Product-Inspired Mimetics via Conformational Profiling
Markham, Lauren E., Koelblen, Thomas, Chobanian, Harry R., Follis, Ariele Viacava, Burris, Thomas P., Micalizio, Glenn C.
Published in ACS central science (28.02.2024)
Published in ACS central science (28.02.2024)
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Journal Article
Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs
Pio, Barbara, Chobanian, Harry R., Guo, Yan, Josien, Hubert, Hagmann, William K., Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Ashley, Eric, Orr, Robert, Wright, Michael J., Bugianesi, Randal, Souza, Sarah, Zhang, Xiaoping, Di Salvo, Jerry, Weinglass, Adam B., Tschirret-Guth, Richard, Samuel, Koppara, Chen, Qing, Shang, Jackie, Lamca, James, Ehrhart, Juliann, Nargund, Ravi, Howard, Andrew D., Colletti, Steven L.
Published in Bioorganic & medicinal chemistry letters (15.07.2019)
Published in Bioorganic & medicinal chemistry letters (15.07.2019)
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Catalyst-Controlled Regioselective Suzuki Couplings at Both Positions of Dihaloimidazoles, Dihalooxazoles, and Dihalothiazoles
Strotman, Neil A, Chobanian, Harry R, He, Jiafang, Guo, Yan, Dormer, Peter G, Jones, Christina M, Steves, Janelle E
Published in Journal of organic chemistry (05.03.2010)
Published in Journal of organic chemistry (05.03.2010)
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Synthesis of novel 2-azabicyclo[3.1.1]heptane-5-carboxylic acid
He, Shuwen, Hao, Jinsong, Ashley, Eric R., Chobanian, Harry R., Pio, Barbara, Colletti, Steven L., Miller, Michael
Published in Tetrahedron letters (16.03.2016)
Published in Tetrahedron letters (16.03.2016)
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Journal Article
Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
Lu, Jun, Byrne, Noel, Wang, John, Bricogne, Gerard, Brown, Frank K, Chobanian, Harry R, Colletti, Steven L, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Guo, Yan, Hall, Dawn L, Hadix, Jennifer, Hastings, Nicholas B, Hermes, Jeffrey D, Ho, Thu, Howard, Andrew D, Josien, Hubert, Kornienko, Maria, Lumb, Kevin J, Miller, Michael W, Patel, Sangita B, Pio, Barbara, Plummer, Christopher W, Sherborne, Bradley S, Sheth, Payal, Souza, Sarah, Tummala, Srivanya, Vonrhein, Clemens, Webb, Maria, Allen, Samantha J, Johnston, Jennifer M, Weinglass, Adam B, Sharma, Sujata, Soisson, Stephen M
Published in Nature structural & molecular biology (01.07.2017)
Published in Nature structural & molecular biology (01.07.2017)
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Journal Article
The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics
Chobanian, Harry R., Guo, Yan, Pio, Barbara, Tang, Haifeng, Teumelsan, Nardos, Clements, Matthew, Frie, Jessica, Ferguson, Ronald, Guo, Zach, Thomas-Fowlkes, Brande S., Felix, John P., Liu, Jessica, Kohler, Martin, Priest, Birgit, Hampton, Caryn, Pai, Lee-Yuh, Corona, Aaron, Metzger, Joseph, Tong, Vincent, Joshi, Elizabeth M., Xu, Ling, Owens, Karen, Maloney, Kevin, Sullivan, Kathleen, Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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Journal Article
Structure–Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs
Chen, Helen Y., Plummer, Christopher W., Xiao, Dong, Chobanian, Harry R., DeMong, Duane, Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Di Salvo, Jerry, Thomas-Fowlkes, Brande, Souza, Sarah, Tatosian, Daniel A., Chen, Qing, Hafey, Michael J., Houle, Robert, Nolting, Andrew F., Orr, Robert, Ehrhart, Juliann, Weinglass, Adam B., Tschirret-Guth, Richard, Howard, Andrew D., Colletti, Steven L.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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Journal Article
Synthesis of a Lactone Diastereomer of the Cembranolide Uprolide D
Marshall, James A, Griot, Céline A, Chobanian, Harry R, Myers, William H
Published in Organic letters (01.10.2010)
Published in Organic letters (01.10.2010)
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Journal Article
Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain
Chobanian, Harry R, Guo, Yan, Liu, Ping, Chioda, Marc D, Fung, Selena, Lanza, Thomas J, Chang, Linda, Bakshi, Raman K, Dellureficio, James P, Hong, Qingmei, McLaughlin, Mark, Belyk, Kevin M, Krska, Shane W, Makarewicz, Amanda K, Martel, Elliot J, Leone, Joseph F, Frey, Lisa, Karanam, Bindhu, Madeira, Maria, Alvaro, Raul, Shuman, Joyce, Salituro, Gino, Terebetski, Jenna L, Jochnowitz, Nina, Mistry, Shruti, McGowan, Erin, Hajdu, Richard, Rosenbach, Mark, Abbadie, Catherine, Alexander, Jessica P, Shiao, Lin-Lin, Sullivan, Kathleen M, Nargund, Ravi P, Wyvratt, Matthew J, Lin, Linus S, DeVita, Robert J
Published in ACS medicinal chemistry letters (12.06.2014)
Published in ACS medicinal chemistry letters (12.06.2014)
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Journal Article
The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization
Chobanian, Harry R., Guo, Yan, Liu, Ping, Lanza, Thomas J., Chioda, Marc, Chang, Linda, Kelly, Theresa M., Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J., Metzger, Joseph M., Raustad, Katie, Wang, Sheng-Ping, Strack, Alison M., Gorski, Judith N., Miller, Randy, Pang, Jianmei, Lyons, Kathy, Dragovic, Jasminka, Ning, Jian G., Schafer, Wes A., Welch, Christopher J., Gong, Xiaoyi, Gao, Ying-Duo, Hornak, Viktor, Reitman, Marc L., Nargund, Ravi P., Lin, Linus S.
Published in Bioorganic & medicinal chemistry (01.05.2012)
Published in Bioorganic & medicinal chemistry (01.05.2012)
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Journal Article
Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement
Chobanian, Harry R, Pio, Barbara, Guo, Yan, Shen, Hong, Huffman, Mark A, Madeira, Maria, Salituro, Gino, Terebetski, Jenna L, Ormes, James, Jochnowitz, Nina, Hoos, Lizbeth, Zhou, Yuchen, Lewis, Dale, Hawes, Brian, Mitnaul, Lyndon, O’Neill, Kim, Ellsworth, Kenneth, Wang, Liangsu, Biftu, Tesfaye, Duffy, Joseph L
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Journal Article
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase
Liu, Ping, Hamill, Terence G, Chioda, Marc, Chobanian, Harry, Fung, Selena, Guo, Yan, Chang, Linda, Bakshi, Raman, Hong, Qingmei, Dellureficio, James, Lin, Linus S, Abbadie, Catherine, Alexander, Jessica, Jin, Hong, Mandala, Suzanne, Shiao, Lin-Lin, Li, Wenping, Sanabria, Sandra, Williams, David, Zeng, Zhizhen, Hajdu, Richard, Jochnowitz, Nina, Rosenbach, Mark, Karanam, Bindhu, Madeira, Maria, Salituro, Gino, Powell, Joyce, Xu, Ling, Terebetski, Jenna L, Leone, Joseph F, Miller, Patricia, Cook, Jacquelynn, Holahan, Marie, Joshi, Aniket, O’Malley, Stacey, Purcell, Mona, Posavec, Diane, Chen, Tsing-Bau, Riffel, Kerry, Williams, Mangay, Hargreaves, Richard, Sullivan, Kathleen A, Nargund, Ravi P, DeVita, Robert J
Published in ACS medicinal chemistry letters (13.06.2013)
Published in ACS medicinal chemistry letters (13.06.2013)
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Journal Article
Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity
Chobanian, Harry R, Guo, Yan, Liu, Ping, Chioda, Marc, Lanza, Thomas J, Chang, Linda, Kelly, Theresa M, Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J, Metzger, Joseph M, Gorski, Judith N, Raustad, Kate, Wang, Sheng-Ping, Strack, Alison M, Miller, Randy, Pang, Jianmei, Madeira, Maria, Lyons, Kathy, Dragovic, Jasminka, Reitman, Marc L, Nargund, Ravi P, Lin, Linus S
Published in ACS medicinal chemistry letters (08.03.2012)
Published in ACS medicinal chemistry letters (08.03.2012)
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