A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling
Wójcik-Pszczoła, Katarzyna, Chłoń-Rzepa, Grażyna, Jankowska, Agnieszka, Ślusarczyk, Marietta, Ferdek, Paweł E, Kusiak, Agnieszka A, Świerczek, Artur, Pociecha, Krzysztof, Koczurkiewicz-Adamczyk, Paulina, Wyska, Elżbieta, Pękala, Elżbieta, Gosens, Reinoud
Published in International journal of molecular sciences (03.06.2020)
Published in International journal of molecular sciences (03.06.2020)
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Antiplatelet Effects of Selected Xanthine-Based Adenosine A2A and A2B Receptor Antagonists Determined in Rat Blood
Kubacka, Monika, Mogilski, Szczepan, Bednarski, Marek, Pociecha, Krzysztof, Świerczek, Artur, Nicosia, Noemi, Schabikowski, Jakub, Załuski, Michał, Chłoń-Rzepa, Grażyna, Hockemeyer, Jörg, Müller, Christa E., Kieć-Kononowicz, Katarzyna, Kotańska, Magdalena
Published in International journal of molecular sciences (01.09.2023)
Published in International journal of molecular sciences (01.09.2023)
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Design and Synthesis of Novel Aminoalkanamides Targeting Neurodegeneration and Symptoms of Alzheimer's Disease
Jankowska, Agnieszka, Satała, Grzegorz, Latacz, Gniewomir, Partyka, Anna, Lubelska, Annamaria, Pociecha, Krzysztof, Świerczek, Artur, Wilczyńska, Natalia, Mordyl, Barbara, Bojarski, Andrzej J, Wyska, Elżbieta, Chłoń-Rzepa, Grażyna
Published in Current medicinal chemistry (01.01.2021)
Published in Current medicinal chemistry (01.01.2021)
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Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A/5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity
Chłoń-Rzepa, Grażyna, Zagórska, Agnieszka, Żmudzki, Paweł, Bucki, Adam, Kołaczkowski, Marcin, Partyka, Anna, Wesołowska, Anna, Kazek, Grzegorz, Głuch-Lutwin, Monika, Siwek, Agata, Starowicz, Gabriela, Pawłowski, Maciej
Published in Archiv der Pharmazie (Weinheim) (01.12.2016)
Published in Archiv der Pharmazie (Weinheim) (01.12.2016)
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Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain
Chłoń-Rzepa, Grażyna, Ślusarczyk, Marietta, Jankowska, Agnieszka, Gawalska, Alicja, Bucki, Adam, Kołaczkowski, Marcin, Świerczek, Artur, Pociecha, Krzysztof, Wyska, Elżbieta, Zygmunt, Małgorzata, Kazek, Grzegorz, Sałat, Kinga, Pawłowski, Maciej
Published in European journal of medicinal chemistry (05.10.2018)
Published in European journal of medicinal chemistry (05.10.2018)
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ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF 8-METHOXY-1,3-DIMETHYL-2,6-DIOXO-PURIN-7-YL DERIVATIVES WITH TERMINAL CARBOXYLIC, ESTER OR AMIDE MOIETIES IN ANIMAL MODELS
Zygmunt, Małgorzata, Chłon-Rzepa, Grazyna, Wyska, Elzbieta, Pociecha, Krzysztof, Sapa, Jacek
Published in Acta Poloniae pharmaceutica (01.05.2016)
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Published in Acta Poloniae pharmaceutica (01.05.2016)
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Multifunctional Ligands Targeting Phosphodiesterase as the Future Strategy for the Symptomatic and Disease-Modifying Treatment of Alzheimer's Disease
Jankowska, Agnieszka, Wesołowska, Anna, Pawłowski, Maciej, Chłoń-Rzepa, Grażyna
Published in Current medicinal chemistry (01.01.2020)
Published in Current medicinal chemistry (01.01.2020)
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Multi-Target-Directed Ligands Affecting Serotonergic Neurotransmission for Alzheimer's Disease Therapy: Advances in Chemical and Biological Research
Jankowska, Agnieszka, Wesolowska, Anna, Pawlowski, Maciej, Chlon-Rzepa, Grazyna
Published in Current medicinal chemistry (2018)
Published in Current medicinal chemistry (2018)
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Multifunctional Ligands with Glycogen Synthase Kinase 3 Inhibitory Activity as a New Direction in Drug Research for Alzheimer's Disease
Jankowska, Agnieszka, Satała, Grzegorz, Bojarski, Andrzej J, Pawłowski, Maciej, Chłoń-Rzepa, GraŻyna
Published in Current medicinal chemistry (01.01.2021)
Published in Current medicinal chemistry (01.01.2021)
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Determination of ligand efficiency indices in a group of 7H‐purine‐2,6‐dione derivatives with psychotropic activity using micellar electrokinetic chromatography
Bajda, Marek, Chłoń‐Rzepa, Grażyna, Żmudzki, Paweł, Czopek, Anna, Stanisz‐Wallis, Krystyna, Łątka, Kamil, Pawłowski, Maciej, Zagórska, Agnieszka
Published in Electrophoresis (01.10.2018)
Published in Electrophoresis (01.10.2018)
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Advances in Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 1: Overview of the Chemical and Biological Research
Jankowska, Agnieszka, Świerczek, Artur, Wyska, Elżbieta, Gawalska, Alicja, Bucki, Adam, Pawłowski, Maciej, Chłoń-Rzepa, Grażyna
Published in Current drug targets (01.01.2019)
Published in Current drug targets (01.01.2019)
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Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach
Świerczek, Artur, Pociecha, Krzysztof, Ślusarczyk, Marietta, Chłoń-Rzepa, Grażyna, Baś, Sebastian, Mlynarski, Jacek, Więckowski, Krzysztof, Zadrożna, Monika, Nowak, Barbara, Wyska, Elżbieta
Published in Pharmaceutical research (01.02.2020)
Published in Pharmaceutical research (01.02.2020)
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Correction to: Comparative Assessment of the New PDE7 Inhibitor – GRMS-55 and Lisofylline in Animal Models of Immune-Related Disorders: A PK/PD Modeling Approach
Świerczek, Artur, Pociecha, Krzysztof, Ślusarczyk, Marietta, Chłoń-Rzepa, Grażyna, Baś, Sebastian, Mlynarski, Jacek, Więckowski, Krzysztof, Zadrożna, Monika, Nowak, Barbara, Wyska, Elżbieta
Published in Pharmaceutical research (01.03.2020)
Published in Pharmaceutical research (01.03.2020)
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Journal Article
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT1A receptor functional profile
Partyka, Anna, Chłoń-Rzepa, Grażyna, Wasik, Anna, Jastrzębska-Więsek, Magdalena, Bucki, Adam, Kołaczkowski, Marcin, Satała, Grzegorz, Bojarski, Andrzej J., Wesołowska, Anna
Published in Bioorganic & medicinal chemistry (01.01.2015)
Published in Bioorganic & medicinal chemistry (01.01.2015)
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Discovery and Development of Non-Dopaminergic Agents for the Treatment of Schizophrenia: Overview of the Preclinical and Early Clinical Studies
Jankowska, Agnieszka, Satała, Grzegorz, Partyka, Anna, Wesołowska, Anna, Bojarski, Andrzej J, Pawłowski, Maciej, Chłoń-Rzepa, Grażyna
Published in Current medicinal chemistry (01.01.2019)
Published in Current medicinal chemistry (01.01.2019)
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Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones
Zygmunt, Małgorzata, Chłoń-Rzepa, Grażyna, Sapa, Jacek
Published in Pharmacological reports (01.12.2014)
Published in Pharmacological reports (01.12.2014)
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PK/PD Modeling of the PDE7 Inhibitor-GRMS-55 in a Mouse Model of Autoimmune Hepatitis
Świerczek, Artur, Plutecka, Hanna, Ślusarczyk, Marietta, Chłoń-Rzepa, Grażyna, Wyska, Elżbieta
Published in Pharmaceutics (21.04.2021)
Published in Pharmaceutics (21.04.2021)
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Journal Article
7-3-Chlorophenypiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione as a serotonin receptor ligands with potential antidepressant activity
Zygmunt, Małgorzata, Sapa, Jacek, Chłoń-Rzepa, Grażyna, Zagórska, Agnieszka, Siwek, Agata, Pawłowski, Maciej, Nowak, Gabriel
Published in Pharmacological reports (01.06.2014)
Published in Pharmacological reports (01.06.2014)
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