Helix-Stabilized Cyclic Peptides as Selective Inhibitors of Steroid Receptor-Coactivator Interactions
Leduc, Anne-Marie, Trent, John O., Wittliff, James L., Bramlett, Kelli S., Briggs, Stephen L., Chirgadze, Nikolay Y., Wang, Yong, Burris, Thomas P., Spatola, Arno F.
Published in Proceedings of the National Academy of Sciences - PNAS (30.09.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (30.09.2003)
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Viracept (Nelfinavir Mesylate, AG1343): A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease
Kaldor, Stephen W, Kalish, Vincent J, Davies, Jay F, Shetty, Bhasker V, Fritz, James E, Appelt, Krzysztof, Burgess, Jeffrey A, Campanale, Kristina M, Chirgadze, Nickolay Y, Clawson, David K, Dressman, Bruce A, Hatch, Steven D, Khalil, Deborah A, Kosa, Maha B, Lubbehusen, Penny P, Muesing, Mark A, Patick, Amy K, Reich, Siegfried H, Su, Kenneth S, Tatlock, John H
Published in Journal of medicinal chemistry (21.11.1997)
Published in Journal of medicinal chemistry (21.11.1997)
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Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis
Chirgadze, Nickolay Y., Briggs, Steven L., McAllister, Kelly A., Fischl, Anthony S., Zhao, Genshi
Published in The EMBO journal (16.10.2000)
Published in The EMBO journal (16.10.2000)
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Indole inhibitors of human nonpancreatic secretory phospholipase A(2) .1. Indole-3-acetamides
Dillard, RD, Bach, NJ, Draheim, SE, Berry, DR, Carlson, DG, Chirgadze, NY, Clawson, DK, Hartley, LW, Johnson, LM, Jones, ND, McKinney, ER, Mihelich, ED, Olkowski, JL, Schevitz, RW, Smith, AC, Snyder, DW, Sommers, CD, Wery, JP
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
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Indole inhibitors of human nonpancreatic secretory phospholipase A(2) .3. Indole-3-glyoxamides
Draheim, SE, Bach, NJ, Dillard, RD, Berry, DR, Carlson, DG, Chirgadze, NY, Clawson, DK, Hartley, LW, Johnson, LM, Jones, ND, McKinney, ER, Mihelich, ED, Olkowski, JL, Schevitz, RW, Smith, AC, Snyder, DW, Sommers, CD, Wery, JP
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
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Structure-Based Design of Potent, Amidine-Derived Inhibitors of Factor Xa: Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity
Wiley, Michael R, Weir, Leonard C, Briggs, Steven, Bryan, Nancy A, Buben, John, Campbell, Charles, Chirgadze, Nickolay Y, Conrad, Richard C, Craft, Trelia J, Ficorilli, James V, Franciskovich, Jeffry B, Froelich, Larry L, Gifford-Moore, Donetta S, Goodson, Theodore, Herron, David K, Klimkowski, Valentine J, Kurz, Kenneth D, Kyle, Jeffery A, Masters, John J, Ratz, Andrew M, Milot, Guy, Shuman, Robert T, Smith, Tommy, Smith, Gerald F, Tebbe, Ann Louise, Tinsley, Jennifer M, Towner, Richard D, Wilson, Alexander, Yee, Ying K
Published in Journal of medicinal chemistry (09.03.2000)
Published in Journal of medicinal chemistry (09.03.2000)
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Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding Orientation
Sall, Daniel J, Bastian, Jolie A, Briggs, Stephen L, Buben, John A, Chirgadze, Nickolay Y, Clawson, David K, Denney, Michael L, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Hauser, Kenneth L, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Smith, Gerald F, Takeuchi, Kumiko, Thrasher, Kenneth J, Tinsley, Jennifer M, Utterback, Barbara G, Yan, Sau-Chi B, Zhang, Minsheng
Published in Journal of medicinal chemistry (24.10.1997)
Published in Journal of medicinal chemistry (24.10.1997)
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Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors. 5. Potency, Efficacy, and Pharmacokinetic Properties of Modified C-3 Side Chain Derivatives
Sall, Daniel J, Bailey, Dianna L, Bastian, Jolie A, Buben, John A, Chirgadze, Nickolay Y, Clemens-Smith, Amy C, Denney, Michael L, Fisher, Matthew J, Giera, Deborah D, Gifford-Moore, Donetta S, Harper, Richard W, Johnson, Lea M, Klimkowski, Valentine J, Kohn, Todd J, Lin, Ho-Shen, McCowan, Jefferson R, Palkowitz, Alan D, Richett, Michael E, Smith, Gerald F, Snyder, David W, Takeuchi, Kumiko, Toth, John E, Zhang, Minsheng
Published in Journal of medicinal chemistry (24.02.2000)
Published in Journal of medicinal chemistry (24.02.2000)
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Indole inhibitors of human nonpancreatic secretory phospholipase A(2) .2. Indole-3-acetamides with additional functionality
Dillard, RD, Bach, NJ, Draheim, SE, Berry, DR, Carlson, DG, Chirgadze, NY, Clawson, DK, Hartley, LW, Johnson, LM, Jones, ND, McKinney, ER, Mihelich, ED, Olkowski, JL, Schevitz, RW, Smith, AC, Snyder, DW, Sommers, CD, Wery, JP
Published in Journal of medicinal chemistry (20.12.1996)
Published in Journal of medicinal chemistry (20.12.1996)
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The crystal structures of human α-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: A binding mode for a structurally novel class of inhibitors
CHIRGADZE, N.Y., SALL, D.J., BRIGGS, S.L., CLAWSON, D.K., ZHANG, M., SMITH, G.F., SCHEVITZ, R.W.
Published in Protein science (01.01.2000)
Published in Protein science (01.01.2000)
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A Single Sequence Change Destabilizes the Influenza Virus Neuraminidase Tetramer
Colacino, Joseph M, Chirgadze, Nickolay Y, Garman, Elspeth, Murti, K.Gopal, Loncharich, Richard J, Baxter, Angela J, Staschke, Kirk A, Laver, W.Graeme
Published in Virology (New York, N.Y.) (15.09.1997)
Published in Virology (New York, N.Y.) (15.09.1997)
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D-Phe-Pro- p-Amidinobenzylamine: A potent and highly selective thrombin inhibitor
Wiley, Michael R., Chirgadze, Nickolay Y., Clawson, David K., Craft, Trelia J., Gifford-Moore, Donetta S., Jones, Noel D., Olkowski, Jennifer L., Weir, Leonard C., Smith, Gerald F.
Published in Bioorganic & medicinal chemistry letters (22.10.1996)
Published in Bioorganic & medicinal chemistry letters (22.10.1996)
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The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element
Wiley, Michael R., Weir, Leonard C., Briggs, Steven L., Chirgadze, Nickolay Y., Clawson, David, Gifford-Moore, Donetta S., Schacht, Aaron L., Smith, Gerald F., Vasudevan, Vasu, Zornes, Larry L., Klimkowski, Valentine J.
Published in Bioorganic & medicinal chemistry letters (20.09.1999)
Published in Bioorganic & medicinal chemistry letters (20.09.1999)
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Serine protease selectivity of the thrombin inhibitor D-Phe-Pro-Agmatine and its homologs
Wiley, Michael R., Chirgadze, Nickolay Y., Clawson, David K., Craft, Trelia J., Gifford-Moore, Donetta S., Jones, Noel D., Olkowski, Jennifer L., Schacht, Aaron L., Weir, Leonard C., Smith, Gerald F.
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
Published in Bioorganic & medicinal chemistry letters (07.12.1995)
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The crystal structure of human α‐thrombin complexed with LY178550, a nonpeptidyl, active site‐directed inhibitor
Chirgadze, Nickolay Y., Sall, Daniel J., Klimkowski, Valentine J., Clawson, David K., Briggs, Steve L., Hermann, Robert, Smith, Gerald F., Gifford‐Moore, Donetta S., Wery, Jean‐Pierre
Published in Protein science (01.07.1997)
Published in Protein science (01.07.1997)
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Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S 2) binding site
Sall, Daniel J., Briggs, Stephen L., Chirgadze, Nickolay Y., Clawson, David K., Gifford-Moore, Donetta S., Klimkowski, Valentine J., McCowan, Jefferson R., Smith, Gerald F., Wikel, James H.
Published in Bioorganic & medicinal chemistry letters (22.09.1998)
Published in Bioorganic & medicinal chemistry letters (22.09.1998)
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Dibasic benzo[ b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2: sidechain optimization and demonstration of in vivo efficacy
Zhang, Minsheng, Bailey, Dianna L., Bastian, Jolie A., Briggs, Stephen L., Chirgadze, Nickolay Y., Clawson, David K., Denney, Michael L., Gifford-Moore, Donetta S., Harper, Richard W., Johnson, Lea M., Klimkowski, Valentine J., Kohn, Todd J., Lin, Ho-Shen, McCowan, Jefferson R., Richett, Michael E., Sall, Daniel J., Smith, Amy J., Smith, Gerald F., Snyder, David W., Takeuchi, Kumiko, Utterback, Barbara G., Yan, Sau-Chi B.
Published in Bioorganic & medicinal chemistry letters (08.03.1999)
Published in Bioorganic & medicinal chemistry letters (08.03.1999)
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