The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis
Wilson, L. F. L., Dendooven, T., Hardwick, S. W., Echevarría-Poza, A., Tryfona, T., Krogh, K. B. R. M., Chirgadze, D. Y., Luisi, B. F., Logan, D. T., Mani, K., Dupree, P.
Published in Nature communications (08.06.2022)
Published in Nature communications (08.06.2022)
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Journal Article
Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein–protein interactions
Núñez Miguel, R, Sanders, J, Chirgadze, D Y, Furmaniak, J, Rees Smith, B
Published in Journal of molecular endocrinology (01.05.2009)
Published in Journal of molecular endocrinology (01.05.2009)
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Journal Article
FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity
Núñez Miguel, R, Sanders, J, Chirgadze, D Y, Blundell, T L, Furmaniak, J, Rees Smith, B
Published in Journal of molecular endocrinology (01.09.2008)
Published in Journal of molecular endocrinology (01.09.2008)
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Journal Article
Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function
Sanders, J, Jeffreys, J, Depraetere, H, Evans, M, Richards, T, Kiddie, A, Brereton, K, Premawardhana, L D K E, Chirgadze, D Y, Núñez Miguel, R, Blundell, T L, Furmaniak, J, Rees Smith, B
Published in Thyroid (New York, N.Y.) (01.08.2004)
Published in Thyroid (New York, N.Y.) (01.08.2004)
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Journal Article
Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist
Sanders, J, Allen, F, Jeffreys, J, Bolton, J, Richards, T, Depraetere, H, Nakatake, N, Evans, M, Kiddie, A, Premawardhana, L D K E, Chirgadze, D Y, Miguel, R Núñez, Blundell, T L, Furmaniak, J, Smith, B Rees
Published in Thyroid (New York, N.Y.) (01.07.2005)
Published in Thyroid (New York, N.Y.) (01.07.2005)
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Journal Article
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor
Lietha, Daniel, Chirgadze, Dimitri Y., Mulloy, Barbara, Blundell, Tom L., Gherardi, Ermanno
Published in The EMBO journal (15.10.2001)
Published in The EMBO journal (15.10.2001)
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Journal Article
Structure of an Xrcc4–DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode
Doré, Andrew S., Furnham, Nicholas, Davies, Owen R., Sibanda, Bancinyane L., Chirgadze, Dimitri Y., Jackson, Stephen P., Pellegrini, Luca, Blundell, Tom L.
Published in DNA repair (07.03.2006)
Published in DNA repair (07.03.2006)
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Journal Article
Structural basis for collagen recognition by the immune receptor OSCAR
Zhou, Long, Hinerman, Jennifer M., Blaszczyk, Michal, Miller, Jeanette L.C., Conrady, Deborah G., Barrow, Alexander D., Chirgadze, Dimitri Y., Bihan, Dominique, Farndale, Richard W., Herr, Andrew B.
Published in Blood (04.02.2016)
Published in Blood (04.02.2016)
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Journal Article
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding
Gherardi, Ermanno, Chirgadze, Dimitri Y, Hepple, Jonathan P, Zhou, Hongjun, Byrd, R. Andrew, Blundell, Tom L
Published in Nature structural biology (01.01.1999)
Published in Nature structural biology (01.01.1999)
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Journal Article
Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation
Chirgadze, Dimitri Y, Hepple, Jonathan, Byrd, R.Andrew, Sowdhamini, R, Blundell, Tom L, Gherardi, Ermanno
Published in FEBS Letters (23.06.1998)
Published in FEBS Letters (23.06.1998)
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Book Review
Journal Article
A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation
De Genst, Erwin, Chan, Pak-Ho, Pardon, Els, Hsu, Shang-Te D, Kumita, Janet R, Christodoulou, John, Menzer, Linda, Chirgadze, Dimitri Y, Robinson, Carol V, Muyldermans, Serge, Matagne, André, Wyns, Lode, Dobson, Christopher M, Dumoulin, Mireille
Published in The journal of physical chemistry. B (24.10.2013)
Published in The journal of physical chemistry. B (24.10.2013)
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Web Resource
High-resolution crystal structure of the human Notch 1 ankyrin domain
Ehebauer, Matthias T, Chirgadze, Dimitri Y, Hayward, Penny, Martinez Arias, Alfonso, Blundell, Tom L
Published in Biochemical journal (15.11.2005)
Published in Biochemical journal (15.11.2005)
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Journal Article
Structural constraints on protein self-processing in L-aspartate-α-decarboxylase
Schmitzberger, Florian, Kilkenny, Mairi L., Lobley, Carina M. C., Webb, Michael E., Vinkovic, Mladen, Matak-Vinkovic, Dijana, Witty, Michael, Chirgadze, Dimitri Y., Smith, Alison G., Abell, Chris, Blundell, Tom L.
Published in The EMBO journal (01.12.2003)
Published in The EMBO journal (01.12.2003)
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Journal Article
Molecular Dissection of the Interaction between the Small G Proteins Rac1 and RhoA and Protein Kinase C-related Kinase 1 (PRK1)
Owen, Darerca, Lowe, Peter N., Nietlispach, Daniel, Brosnan, C. Elaine, Chirgadze, Dimitri Y., Parker, Peter J., Blundell, Tom L., Mott, Helen R.
Published in The Journal of biological chemistry (12.12.2003)
Published in The Journal of biological chemistry (12.12.2003)
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Journal Article
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor
Lietha, D., Chirgadze, D. Y., Mulloy, M., Blundell, T. L., Gherardi, E.
Published in Acta crystallographica. Section A, Foundations of crystallography (06.08.2002)
Published in Acta crystallographica. Section A, Foundations of crystallography (06.08.2002)
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Journal Article
A New Crystal Form of the NK1 Splice Variant of HGF/SF Demonstrates Extensive Hinge Movement and Suggests That the NK1 Dimer Originates by Domain Swapping
Watanabe, Keiichi, Chirgadze, Dimitri Y., Lietha, Daniel, de Jonge, Hugo, Blundell, Tom L., Gherardi, Ermanno
Published in Journal of molecular biology (31.05.2002)
Published in Journal of molecular biology (31.05.2002)
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