The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases
Hogan, Kelly A, Chini, Claudia C S, Chini, Eduardo N
Published in Frontiers in immunology (31.05.2019)
Published in Frontiers in immunology (31.05.2019)
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Journal Article
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
Palmer, Allyson K, Tchkonia, Tamara, LeBrasseur, Nathan K, Chini, Eduardo N, Xu, Ming, Kirkland, James L
Published in Diabetes (New York, N.Y.) (01.07.2015)
Published in Diabetes (New York, N.Y.) (01.07.2015)
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Journal Article
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Camacho-Pereira, Juliana, Tarragó, Mariana G., Chini, Claudia C.S., Nin, Veronica, Escande, Carlos, Warner, Gina M., Puranik, Amrutesh S., Schoon, Renee A., Reid, Joel M., Galina, Antonio, Chini, Eduardo N.
Published in Cell metabolism (14.06.2016)
Published in Cell metabolism (14.06.2016)
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Journal Article
The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging
Chini, Eduardo N., Chini, Claudia C.S., Espindola Netto, Jair Machado, de Oliveira, Guilherme C., van Schooten, Wim
Published in Trends in pharmacological sciences (Regular ed.) (01.04.2018)
Published in Trends in pharmacological sciences (Regular ed.) (01.04.2018)
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Journal Article
A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline
Tarragó, Mariana G., Chini, Claudia C.S., Kanamori, Karina S., Warner, Gina M., Caride, Ariel, de Oliveira, Guilherme C., Rud, Micaela, Samani, Adrienne, Hein, Kyaw Z., Huang, Runqing, Jurk, Diana, Cho, Dong Seong, Boslett, James J., Miller, Jordan D., Zweier, Jay L., Passos, João F., Doles, Jason D., Becherer, David J., Chini, Eduardo N.
Published in Cell metabolism (01.05.2018)
Published in Cell metabolism (01.05.2018)
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Journal Article
Food Restriction Ameliorates the Development of Polycystic Kidney Disease
Warner, Gina, Hein, Kyaw Zaw, Nin, Veronica, Edwards, Marika, Chini, Claudia C S, Hopp, Katharina, Harris, Peter C, Torres, Vicente E, Chini, Eduardo N
Published in Journal of the American Society of Nephrology (01.05.2016)
Published in Journal of the American Society of Nephrology (01.05.2016)
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Journal Article
Evaluation of the Aging Effect on Peripheral Nerve Regeneration: A Systematic Review
Maita, Karla C., Garcia, John P., Avila, Francisco R., Torres-Guzman, Ricardo A., Ho, Olivia, Chini, Claudia C.S., Chini, Eduardo N., Forte, Antonio J.
Published in The Journal of surgical research (01.08.2023)
Published in The Journal of surgical research (01.08.2023)
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Journal Article
A stress-induced cilium-to-PML-NB route drives senescence initiation
Ma, Xiaoyu, Zhang, Yingyi, Zhang, Yuanyuan, Zhang, Xu, Huang, Yan, He, Kai, Chen, Chuan, Hao, Jielu, Zhao, Debiao, LeBrasseur, Nathan K., Kirkland, James L., Chini, Eduardo N., Wei, Qing, Ling, Kun, Hu, Jinghua
Published in Nature communications (03.04.2023)
Published in Nature communications (03.04.2023)
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Journal Article
Targeting of NAD Metabolism in Pancreatic Cancer Cells: Potential Novel Therapy for Pancreatic Tumors
CHINI, Claudia C. S, GUERRICO, Anatilde M. Gonzalez, NIN, Veronica, CAMACHO-PEREIRA, Juliana, ESCANDE, Carlos, BARBOSA, Maria Thereza, CHINI, Eduardo N
Published in Clinical cancer research (01.01.2014)
Published in Clinical cancer research (01.01.2014)
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Journal Article
Heavy-chain antibody targeting of CD38 NAD+ hydrolase ectoenzyme to prevent fibrosis in multiple organs
Shi, Bo, Amin, Asif, Dalvi, Pranjali, Wang, Wenxia, Lukacs, Nicholas, Kai, Li, Cheresh, Paul, Peclat, Thais R., Chini, Claudia C., Chini, Eduardo N., van Schooten, Wim, Varga, John
Published in Scientific reports (12.12.2023)
Published in Scientific reports (12.12.2023)
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Journal Article
Regulation of intracellular levels of NAD: A novel role for CD38
Aksoy, Pinar, White, Thomas A., Thompson, Michael, Chini, Eduardo N.
Published in Biochemical and biophysical research communications (14.07.2006)
Published in Biochemical and biophysical research communications (14.07.2006)
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Journal Article
CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging
Peclat, Thais R., Thompson, Katie L., Warner, Gina M., Chini, Claudia C.S., Tarragó, Mariana G., Mazdeh, Delaram Z., Zhang, Chunlian, Zavala‐Solorio, Jose, Kolumam, Ganesh, Liang Wong, Yao, Cohen, Robert L., Chini, Eduardo N.
Published in Aging cell (01.04.2022)
Published in Aging cell (01.04.2022)
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Journal Article
p21 induces a senescence program and skeletal muscle dysfunction
Englund, Davis A., Jolliffe, Alyssa, Aversa, Zaira, Zhang, Xu, Sturmlechner, Ines, Sakamoto, Ayumi E., Zeidler, Julianna D., Warner, Gina M., McNinch, Colton, White, Thomas A., Chini, Eduardo N., Baker, Darren J., van Deursen, Jan M., LeBrasseur, Nathan K.
Published in Molecular metabolism (Germany) (01.01.2023)
Published in Molecular metabolism (Germany) (01.01.2023)
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Journal Article
An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis
Abe, Jun-ichi, Imanishi, Masaki, Li, Shengyu, Zhang, Aijun, Ko, Kyung Ae, Samanthapudi, Venkata S.K., Lee, Ling-Ling, Bojorges, Angelica Paniagua, Gi, Young Jin, Hobbs, Brian P., Deswal, Anita, Herrmann, Joerg, Lin, Steven H., Chini, Eduardo N., Shen, Ying H., Schadler, Keri L., Nguyen, Thi-Hong-Minh, Gupte, Anisha A., Reyes-Gibby, Cielito, Yeung, Sai-Ching J., Abe, Rei J., Olmsted-Davis, Elizabeth A., Krishnan, Sunil, Dantzer, Robert, Palaskas, Nicolas L., Cooke, John P., Pownall, Henry J., Yoshimoto, Momoko, Fujiwara, Keigi, Hamilton, Dale J., Burks, Jared K., Wang, Guangyu, Le, Nhat-Tu, Kotla, Sivareddy
Published in Circulation research (23.06.2023)
Published in Circulation research (23.06.2023)
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Journal Article
Dihydronicotinamide Riboside Is a Potent NAD + Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages
Chini, Claudia C S, Peclat, Thais R, Gomez, Lilian S, Zeidler, Julianna D, Warner, Gina M, Kashyap, Sonu, Mazdeh, Delaram Z, Hayat, Faisal, Migaud, Marie E, Paulus, Aneel, Chanan-Khan, Asher A, Chini, Eduardo N
Published in Frontiers in immunology (25.02.2022)
Published in Frontiers in immunology (25.02.2022)
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Journal Article
Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer
Espindola-Netto, Jair Machado, Chini, Claudia C S, Tarragó, Mariana, Wang, Enfeng, Dutta, Shamit, Pal, Krishnendu, Mukhopadhyay, Debabrata, Sola-Penna, Mauro, Chini, Eduardo N
Published in Oncotarget (17.10.2017)
Published in Oncotarget (17.10.2017)
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Journal Article
CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype
de Zélicourt, Antoine, Fayssoil, Abdallah, Dakouane‐Giudicelli, Mbarka, De Jesus, Isley, Karoui, Ahmed, Zarrouki, Faouzi, Lefebvre, Florence, Mansart, Arnaud, Launay, Jean‐Marie, Piquereau, Jerome, Tarragó, Mariana G, Bonay, Marcel, Forand, Anne, Moog, Sophie, Piétri‐Rouxel, France, Brisebard, Elise, Chini, Claudia C S, Kashyap, Sonu, Fogarty, Matthew J, Sieck, Gary C, Mericskay, Mathias, Chini, Eduardo N, Gomez, Ana Maria, Cancela, José‐Manuel, de la Porte, Sabine
Published in EMBO molecular medicine (09.05.2022)
Published in EMBO molecular medicine (09.05.2022)
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Journal Article
SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway
Chini, Claudia C S, Espindola-Netto, Jair M, Mondal, Gourish, Guerrico, Anatilde M Gonzalez, Nin, Veronica, Escande, Carlos, Sola-Penna, Mauro, Zhang, Jin-San, Billadeau, Daniel D, Chini, Eduardo N
Published in Clinical cancer research (15.05.2016)
Published in Clinical cancer research (15.05.2016)
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Journal Article
SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice
Tulino, Raffaella, Benjamin, Agnesska C, Jolinon, Nelly, Smith, Donna L, Chini, Eduardo N, Carnemolla, Alisia, Bates, Gillian P
Published in PloS one (27.01.2016)
Published in PloS one (27.01.2016)
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