Target identification using drug affinity responsive target stability (DARTS)
Lomenick, Brett, Hao, Rui, Jonai, Nao, Chin, Randall M, Aghajan, Mariam, Warburton, Sarah, Wang, Jianing, Wu, Raymond P, Gomez, Fernando, Loo, Joseph A, Wohlschlegel, James A, Vondriska, Thomas M, Pelletier, Jerry, Herschman, Harvey R, Clardy, Jon, Clarke, Catherine F, Huang, Jing
Published in Proceedings of the National Academy of Sciences - PNAS (22.12.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (22.12.2009)
Get full text
Journal Article
2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling
Fu, Xudong, Chin, Randall M., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Xing, Yanpeng, Pai, Melody Y., Li, Sichen, Ta, Lisa, Fazlollahi, Farbod, Chen, Chuo, Prins, Robert M., Teitell, Michael A., Nathanson, David A., Lai, Albert, Faull, Kym F., Jiang, Meisheng, Clarke, Steven G., Cloughesy, Timothy F., Graeber, Thomas G., Braas, Daniel, Christofk, Heather R., Jung, Michael E., Reue, Karen, Huang, Jing
Published in Cell metabolism (01.09.2015)
Published in Cell metabolism (01.09.2015)
Get full text
Journal Article
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Chin, Randall M., Fu, Xudong, Pai, Melody Y., Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S., Monsalve, Gabriela C., Hu, Eileen, Whelan, Stephen A., Wang, Jennifer X., Jung, Gwanghyun, Solis, Gregory M., Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S., Godwin, Hilary A., Chang, Helena R., Faull, Kym F., Guo, Feng, Jiang, Meisheng, Trauger, Sunia A., Saghatelian, Alan, Braas, Daniel, Christofk, Heather R., Clarke, Catherine F., Teitell, Michael A., Petrascheck, Michael, Reue, Karen, Jung, Michael E., Frand, Alison R., Huang, Jing
Published in Nature (London) (19.06.2014)
Published in Nature (London) (19.06.2014)
Get full text
Journal Article
KETOBUTYRATE COMPOUNDS AND COMPOSITIONS FOR TREATING AGE-RELATED SYMPTOMS AND DISEASES
HWANG HEEJUN, LOMENICK BRETT E, JIANG MEISHENG, KHACHATOORIAN RONIK, CHIN RANDALL M, FU XUDONG, LI JINGYUAN, YIN XIANG, FRENCH SAMUEL WHEELER, VERGNES LAURENT, REUE KAREN, EGHBALI MANSOUREH, HUANG JING
Year of Publication 14.02.2017
Get full text
Year of Publication 14.02.2017
Patent
The metabolite [alpha]-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Chin, Randall M, Fu, Xudong, Pai, Melody Y, Vergnes, Laurent, Hwang, Heejun, Deng, Gang, Diep, Simon, Lomenick, Brett, Meli, Vijaykumar S, Monsalve, Gabriela C, Hu, Eileen, Whelan, Stephen A, Wang, Jennifer X, Jung, Gwanghyun, Solis, Gregory M, Fazlollahi, Farbod, Kaweeteerawat, Chitrada, Quach, Austin, Nili, Mahta, Krall, Abby S, Godwin, Hilary A, Chang, Helena R, Faull, Kym F, Guo, Feng, Jiang, Meisheng, Trauger, Sunia A, Saghatelian, Alan, Braas, Daniel, Christofk, Heather R, Clarke, Catherine F, Teitell, Michael A, Petrascheck, Michael, Reue, Karen, Jung, Michael E, Frand, Alison R, Huang, Jing
Published in Nature (London) (19.06.2014)
Get full text
Published in Nature (London) (19.06.2014)
Journal Article
Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models
Chin, Randall M, Rakhit, Rishi, Ditsworth, Dara, Wang, Chengzhong, Bartholomeus, Johan, Liu, Song, Mody, Akash, Laishu, Alex, Eastes, Andrea, Tai, Chao, Kim, Roy Y, Li, Jessica, Hansberry, Steven, Khasnavis, Saurabh, Rafalski, Victoria, Herendeen, Donald, Garda, Virginia, Phung, Jennie, de Roulet, Daniel, Ordureau, Alban, Harper, J Wade, Johnstone, Shawn, Stöhr, Jan, Hertz, Nicholas T
Published in bioRxiv : the preprint server for biology (15.02.2023)
Get more information
Published in bioRxiv : the preprint server for biology (15.02.2023)
Journal Article
Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms
Fu, Xudong, Lomenick, Brett Eugene, Reue, Karen Lynn, Vergnes, Laurent, Deng, Gang, Jung, Michael E, Huang, Jing, Chin, Randall M, Pai, Melody Y, Jiang, Meisheng, Diep, Simon, Hwang, Heejun
Year of Publication 13.07.2023
Get full text
Year of Publication 13.07.2023
Patent
Compositions and Methods for Treating Neurodegenerative Diseases
Lomenick, Brett Eugene, Huang, Jing, Jiang, Meisheng, Chin, Randall M, Chai, Min
Year of Publication 13.08.2020
Get full text
Year of Publication 13.08.2020
Patent
COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES
LOMENICK, Brett Eugene, JIANG, Meisheng, CHAI, Min, HUANG, Jing, CHIN, Randall M
Year of Publication 01.07.2020
Get full text
Year of Publication 01.07.2020
Patent
COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES
LOMENICK, Brett Eugene, JIANG, Meisheng, CHAI, Min, HUANG, Jing, CHIN, Randall M
Year of Publication 28.02.2019
Get full text
Year of Publication 28.02.2019
Patent
The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK
Chen, Chieh, Lomenick, Brett, Chai, Min, Huang, Wilson, Chu, Jessie, Vergnes, Laurent, Johnson, Reid O, Vashisht, Ajay A, Chin, Randall M, Dix, Melissa M, Simon, Gabriel, Fu, Xudong, Link, Jenny C, Hwang, Heejun, Yin, Xiang, De Barros, Stephanie C, Braas, Daniel, Kim, Nahn H, Wang, Yibin, Dubinett, Steven M, Teitell, Michael A, Fiehn, Oliver, Jiang, Meisheng, Cravatt, Benjamin F, Wohlschlegel, James A, Loo, Joseph A, Reue, Karen, Huang, Jing
Published in bioRxiv (13.10.2022)
Published in bioRxiv (13.10.2022)
Get full text
Paper
Ketobutyrate compounds and compositions for treating age-related symptoms and diseases
Fu, Xudong, French, Samuel Wheeler, Yin, Xiang, Vergnes, Laurent, Eghbali, Mansoureh, Li, Jingyuan, Huang, Jing, Chin, Randall M, Jiang, Meisheng, Lomenick, Brett E, Khachatoorian, Ronik, Reue, Karen, Hwang, Heejun
Year of Publication 04.08.2020
Get full text
Year of Publication 04.08.2020
Patent
Compositions and Methods for Treating Aging and Age-Related Diseases and Symptoms
Fu, Xudong, Lomenick, Brett Eugene, Vergnes, Laurent, Deng, Gang, Jung, Michael E, Huang, Jing, Chin, Randall M, Pai, Melody Y, Jiang, Meisheng, Diep, Simon, Reue, Karen, Hwang, Heejun
Year of Publication 27.06.2019
Get full text
Year of Publication 27.06.2019
Patent
Ketobutyrate Compounds and Compositions for Treating Age-Related Symptoms and Diseases
Lomenick Brett E, Khachatoorian Ronik, Fu Xudong, French Samuel Wheeler, Hwang Heejun, Jiang Meisheng, Reue Karen, Huang Jing, Eghbali Mansoureh, Chin Randall M, Vergnes Laurent, Yin Xiang, Li Jingyuan
Year of Publication 11.05.2017
Get full text
Year of Publication 11.05.2017
Patent