Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease
Zimmer, Daniel P, Shea, Courtney M, Tobin, Jenny V, Tchernychev, Boris, Germano, Peter, Sykes, Kristie, Banijamali, Ali R, Jacobson, Sarah, Bernier, Sylvie G, Sarno, Renee, Carvalho, Andrew, Chien, Yueh-Tyng, Graul, Regina, Buys, Emmanuel S, Jones, Juli E, Wakefield, James D, Price, Gavrielle M, Chickering, Jennifer G, Milne, G Todd, Currie, Mark G, Masferrer, Jaime L
Published in Frontiers in pharmacology (08.04.2020)
Published in Frontiers in pharmacology (08.04.2020)
Get full text
Journal Article
Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial
Hanrahan, John P, de Boer, Ian H, Bakris, George L, Wilson, Phebe J, Wakefield, James D, Seferovic, Jelena P, Chickering, Jennifer G, Chien, Yueh-Tyng, Carlson, Kenneth, Cressman, Michael D, Currie, Mark G, Milne, G Todd, Profy, Albert T
Published in Clinical journal of the American Society of Nephrology (2021)
Published in Clinical journal of the American Society of Nephrology (2021)
Get full text
Journal Article
Agr‐independent regulation of fibronectin‐binding protein(s) by the regulatory locus sar in Staphylococcus aureus
Wolz, Christiane, Pöhlmann‐Dietze, Petra, Steinhuber, Andrea, Chien, Yueh‐Tyng, Manna, Adhar, Van Wamel, Willem, Cheung, Ambrose
Published in Molecular microbiology (01.04.2000)
Published in Molecular microbiology (01.04.2000)
Get full text
Journal Article
SarA level is a determinant of agr activation in Staphylococcus aureus
Chien, Yueh‐tyng, Manna, Adhar C., Cheung, Ambrose L.
Published in Molecular microbiology (01.12.1998)
Published in Molecular microbiology (01.12.1998)
Get full text
Journal Article
Analysis of genes encoding an alternative nitrogenase in the archaeon Methanosarcina barkeri 227
Chien, Y T, Auerbuch, V, Brabban, A D, Zinder, S H
Published in Journal of bacteriology (01.06.2000)
Published in Journal of bacteriology (01.06.2000)
Get full text
Journal Article
Mo1504 - The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo
Zimmer, Daniel P., Silva, Ines A., Chien, Yueh-tyng, Milne, G. Todd, Currie, Mark
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Get full text
Journal Article
SarA, a Global Regulator of Virulence Determinants inStaphylococcus aureus, Binds to a Conserved Motif Essential for sar-dependent Gene Regulation
Chien, Yueh-tyng, Manna, Adhar C., Projan, Steven J., Cheung, Ambrose L.
Published in The Journal of biological chemistry (01.12.1999)
Published in The Journal of biological chemistry (01.12.1999)
Get full text
Journal Article
The Soluble Guanylate Cyclase Stimulator IW-1701 Enhances Nitric Oxide-Mediated Relaxation of Human Lower Esophageal Sphincter ex vivo
Zimmer, Daniel P, Silva, Ines A, Chien, Yueh-tyng, Milne, G. Todd, Currie, Mark
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2017)
Get full text
Journal Article
Multiple-Ascending-Dose Study of the Soluble Guanylate Cyclase Stimulator, IW-1701, in Healthy Subjects
Mittleman, Robert S, Wilson, Phebe, Sykes, Kristine, Mihova, Marina, Chickering, Jennifer G, Ruff, Dennis, Hall, Michael, Milne, Todd G, Currie, Mark G, Chien, Yueh-Tyng
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
Get full text
Journal Article
The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice
Tchernychev, Boris, Feil, Susanne, Germano, Peter, Warren, William, Lonie, Elisabeth, Feil, Robert, Milne, Todd G, Hadcock, John, Chien, Yueh-Tyng, Currie, Mark G, Graul, Regina Margaret
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
Get full text
Journal Article
P154 - Evaluation of methodologies to assess intracellular cGMP levels induced by soluble guanylate cyclase (sGC) stimulators in whole cells
Liu, Guang, Butler, Christina, Long, Kim, Sarno, Renee, Solinga, Rob, Tang, Kim, Chien, Yueh-tyng, Carlson, Ken, Segal, Jeff
Published in Nitric oxide (15.11.2014)
Published in Nitric oxide (15.11.2014)
Get full text
Journal Article
Evaluation of methodologies to assess intracellular cGMP levels induced by soluble guanylate cyclase (sGC) stimulators in whole cells
Liu, Guang, Butler, Christina, Long, Kim, Sarno, Renee, Solinga, Rob, Tang, Kim, Chien, Yueh-tyng, Carlson, Ken, Segal, Jeff
Published in Nitric oxide (01.11.2014)
Published in Nitric oxide (01.11.2014)
Get full text
Journal Article
P158 - IWP-051, a novel, orally available small molecule soluble guanylate cyclase (sGC) stimulator with once-daily dosing potential for the treatment of cardiovascular diseases
Milne, Todd, Butler, Chrissie, Miyashiro, Joy, Jacobson, Sarah, Tobin, Jenny, Solberg, Erik, Shea, Courtney, Germano, Peter, Moore, Joel, Chien, Yueh-tyng, Zimmer, Daniel
Published in Nitric oxide (15.11.2014)
Published in Nitric oxide (15.11.2014)
Get full text
Journal Article
IWP-051, a novel, orally available small molecule soluble guanylate cyclase (sGC) stimulator with once-daily dosing potential for the treatment of cardiovascular diseases
Milne, Todd, Butler, Chrissie, Miyashiro, Joy, Jacobson, Sarah, Tobin, Jenny, Solberg, Erik, Shea, Courtney, Germano, Peter, Moore, Joel, Chien, Yueh-tyng, Zimmer, Daniel
Published in Nitric oxide (01.11.2014)
Published in Nitric oxide (01.11.2014)
Get full text
Journal Article