A peptide triple agonist of GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors promotes glycemic control and weight loss
Chichura, Kylie S, Elfers, Clinton T, Salameh, Therese S, Kamat, Varun, Chepurny, Oleg G, McGivney, Aelish, Milliken, Brandon T, Holz, George G, Applebey, Sarah V, Hayes, Matthew R, Sweet, Ian R, Roth, Christian L, Doyle, Robert P
Published in Scientific reports (12.06.2023)
Published in Scientific reports (12.06.2023)
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The novel chimeric multi-agonist peptide (GEP44) reduces energy intake and body weight in male and female diet-induced obese mice in a glucagon-like peptide-1 receptor-dependent manner
Blevins, James E., Honeycutt, Mackenzie K., Slattery, Jared D., Goldberg, Matvey, Rambousek, June R., Tsui, Edison, Dodson, Andrew D., Shelton, Kyra A., Salemeh, Therese S., Elfers, Clinton T., Chichura, Kylie S., Ashlaw, Emily F., Zraika, Sakeneh, Doyle, Robert P., Roth, Christian L.
Published in Frontiers in endocrinology (Lausanne) (22.07.2024)
Published in Frontiers in endocrinology (Lausanne) (22.07.2024)
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Design and Evaluation of Peptide Dual-Agonists of GLP‑1 and NPY2 Receptors for Glucoregulation and Weight Loss with Mitigated Nausea and Emesis
Milliken, Brandon T, Elfers, Clinton, Chepurny, Oleg G, Chichura, Kylie S, Sweet, Ian R, Borner, Tito, Hayes, Matthew R, De Jonghe, Bart C, Holz, George G, Roth, Christian L, Doyle, Robert P
Published in Journal of medicinal chemistry (28.01.2021)
Published in Journal of medicinal chemistry (28.01.2021)
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Reductions of food intake and body weight in diet-induced obese rats following chronic treatment with a monomeric peptide multiagonist
Elfers, Clinton T., Chichura, Kylie S., Ashlaw, Emily F., Chepurny, Oleg G., Holz, George G., Doyle, Robert P., Roth, Christian L.
Published in Clinical nutrition (Edinburgh, Scotland) (01.07.2024)
Published in Clinical nutrition (Edinburgh, Scotland) (01.07.2024)
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Harnessing Multiple, Nonproteogenic Substitutions to Optimize CSP:ComD Hydrophobic Interactions in Group 1 Streptococcus pneumoniae
Milly, Tahmina A., Engler, Emilee R., Chichura, Kylie S., Buttner, Alec R., Koirala, Bimal, Tal‐Gan, Yftah, Bertucci, Michael A.
Published in Chembiochem : a European journal of chemical biology (02.06.2021)
Published in Chembiochem : a European journal of chemical biology (02.06.2021)
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The Novel Chimeric Multi-Agonist Peptide (GEP44) Reduces Energy Intake and Body Weight in Male and Female Diet-Induced Obese Mice in a Glucagon-Like Peptide-1 Receptor-Dependent Manner
Blevins, James E, Honeycutt, Mackenzie K, Slattery, Jared D, Goldberg, Matvey, Rambousek, June R, Tsui, Edison, Dodson, Andrew D, Shelton, Kyra A, Salemeh, Therese S, Elfers, Clinton T, Chichura, Kylie S, Ashlaw, Emily F, Zraika, Sakeneh, Doyle, Robert P, Roth, Christian L
Published in bioRxiv : the preprint server for biology (21.05.2024)
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Published in bioRxiv : the preprint server for biology (21.05.2024)
Journal Article
The Novel Chimeric Multi-Agonist Peptide (GEP44) Reduces Energy Intake and Body Weight in Male and Female Diet-Induced Obese Mice in a Glucagon-Like Peptide-1 Receptor-Dependent Manner
Blevins, James E, Honeycutt, Mackenzie K, Slattery, Jared D, Goldberg, Matvey, Rambousek, June R, Tsui, Edison, Dodson, Andrew D, Shelton, Kyra A, Salemeh, Therese S, Elfers, Clinton T, Chichura, Kylie S, Ashlaw, Emily F, Zraika, Sakeneh, Doyle, Robert P, Roth, Christian L
Published in bioRxiv (21.05.2024)
Published in bioRxiv (21.05.2024)
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Journal Article