Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
Lu, Jun, Chew, Eng-Hui, Holmgren, Arne
Published in Proceedings of the National Academy of Sciences - PNAS (24.07.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (24.07.2007)
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Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase
Ng, Hui-Li, Ma, Xiang, Chew, Eng-Hui, Chui, Wai-Keung
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
Ribisins and Certain Analogues Exert Neuroprotective Effects through Activation of the Keap1‐Nrf2‐ARE Pathway
Tan, Shen H., Karuppasamy, Muthukumar, Lan, Ping, Zhang, Yaochun, Hu, Jiayi, Lai, Xingchen, Siok‐Cheng Lim, Belinda, Liu, Weiliang, Chen, Jing, Chew, Eng‐Hui, Banwell, Martin G.
Published in ChemMedChem (16.09.2022)
Published in ChemMedChem (16.09.2022)
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Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury
Zhang, Yao-Chun, Gan, Fei-Fei, Shelar, Sandeep Balu, Ng, Ka-Yun, Chew, Eng-Hui
Published in Food and chemical toxicology (01.09.2013)
Published in Food and chemical toxicology (01.09.2013)
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Journal Article
Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention
Chew, Eng-Hui, Nagle, Amrita A., Zhang, Yaochun, Scarmagnani, Silvia, Palaniappan, Puvithira, Bradshaw, Tracey D., Holmgren, Arne, Westwell, Andrew D.
Published in Free radical biology & medicine (2010)
Published in Free radical biology & medicine (2010)
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Journal Article
Induction of tumor cell death through targeting tubulin and evoking dysregulation of cell cycle regulatory proteins by multifunctional cinnamaldehydes
Nagle, Amrita A, Gan, Fei-Fei, Jones, Gavin, So, Choon-Leng, Wells, Geoffrey, Chew, Eng-Hui
Published in PloS one (21.11.2012)
Published in PloS one (21.11.2012)
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3-(2-Oxoethylidene)indolin-2-one Derivatives Activate Nrf2 and Inhibit NF-κB: Potential Candidates for Chemoprevention
Nagle, Amrita A., Reddy, Shridhivya A., Bertrand, Helene, Tajima, Hisashi, Dang, Truong-Minh, Wong, Siew-Cheng, Hayes, John D., Wells, Geoffrey, Chew, Eng-Hui
Published in ChemMedChem (01.08.2014)
Published in ChemMedChem (01.08.2014)
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Journal Article
Quinols as Novel Therapeutic Agents. 2. 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and Related Agents as Potent and Selective Antitumor Agents
Berry, Jane M, Bradshaw, Tracey D, Fichtner, Iduna, Ren, Ruobo, Schwalbe, Carl H, Wells, Geoffrey, Chew, Eng-Hui, Stevens, Malcolm F. G, Westwell, Andrew D
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
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Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway
Gan, Fei-Fei, Zhang, Ruirui, Ng, Hui-Li, Karuppasamy, Muthukumar, Seah, Waygene, Yeap, Wei Hseun, Ong, Siew-Min, Hadadi, Eva, Wong, Siew-Cheng, Chui, Wai-Keung, Chew, Eng-Hui
Published in Food and chemical toxicology (01.06.2018)
Published in Food and chemical toxicology (01.06.2018)
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Journal Article
Identification of Michael acceptor-centric pharmacophores with substituents that yield strong thioredoxin reductase inhibitory character correlated to antiproliferative activity
Gan, Fei-Fei, Kaminska, Kamila K, Yang, Hong, Liew, Chin-Yee, Leow, Pay-Chin, So, Choon-Leng, Tu, Lan N L, Roy, Amrita, Yap, Chun-Wei, Kang, Tse-Siang, Chui, Wai-Keung, Chew, Eng-Hui
Published in Antioxidants & redox signaling (10.10.2013)
Published in Antioxidants & redox signaling (10.10.2013)
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Validity and reliability of the ten-item Connor–Davidson Resilience Scale (CD-RISC10) instrument in patients with axial spondyloarthritis (axSpA) in Singapore
Kwan, Yu Heng, Ng, Amanda, Lim, Ka Keat, Fong, Warren, Phang, Jie Kie, Chew, Eng Hui, Lui, Nai Lee, Tan, Chuen Seng, Thumboo, Julian, Østbye, Truls, Leung, Ying Ying
Published in Rheumatology international (01.01.2019)
Published in Rheumatology international (01.01.2019)
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Journal Article
Thioredoxin-dependent regulation of AIF-mediated DNA damage
Shelar, Sandeep B., Kaminska, Kamila K., Reddy, Shridhivya A., Kumar, Dilip, Tan, Chong-Teik, Yu, Victor C., Lu, Jun, Holmgren, Arne, Hagen, Thilo, Chew, Eng-Hui
Published in Free radical biology & medicine (01.10.2015)
Published in Free radical biology & medicine (01.10.2015)
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