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Published in Cancer cell (12.10.2015)
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Naturally Occurring Neomorphic PIK3R1 Mutations Activate the MAPK Pathway, Dictating Therapeutic Response to MAPK Pathway Inhibitors
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Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer
Liang, Han, Cheung, Lydia W T, Li, Jie, Ju, Zhenlin, Yu, Shuangxing, Stemke-Hale, Katherine, Dogruluk, Turgut, Lu, Yiling, Liu, Xiuping, Gu, Chao, Guo, Wei, Scherer, Steven E, Carter, Hannah, Westin, Shannon N, Dyer, Mary D, Verhaak, Roeland G W, Zhang, Fan, Karchin, Rachel, Liu, Chang-Gong, Lu, Karen H, Broaddus, Russell R, Scott, Kenneth L, Hennessy, Bryan T, Mills, Gordon B
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Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
Li, Xinran, Mak, Victor C. Y., Zhou, Yuan, Wang, Chao, Wong, Esther S. Y., Sharma, Rakesh, Lu, Yiling, Cheung, Annie N. Y., Mills, Gordon B., Cheung, Lydia W. T.
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APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis
Long, Xiaoran, Lu, Huaiwu, Cai, Mei-Chun, Zang, Jingyu, Zhang, Zhuqing, Wu, Jie, Liu, Xiaoshi, Cheng, Lin, Cheng, Jiejun, Cheung, Lydia W. T., Shen, Zhen, Zhou, Ying, Di, Wen, Zhuang, Guanglei, Yin, Xia
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p85β regulates autophagic degradation of AXL to activate oncogenic signaling
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High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability
Cheung, Lydia W T, Hennessy, Bryan T, Li, Jie, Yu, Shuangxing, Myers, Andrea P, Djordjevic, Bojana, Lu, Yiling, Stemke-Hale, Katherine, Dyer, Mary D, Zhang, Fan, Ju, Zhenlin, Cantley, Lewis C, Scherer, Steven E, Liang, Han, Lu, Karen H, Broaddus, Russell R, Mills, Gordon B
Published in Cancer discovery (01.07.2011)
Published in Cancer discovery (01.07.2011)
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Somatic mutations of PIK3R1 promote gliomagenesis
Quayle, Steven N, Lee, Jennifer Y, Cheung, Lydia W T, Ding, Li, Wiedemeyer, Ruprecht, Dewan, Robert W, Huang-Hobbs, Emmet, Zhuang, Li, Wilson, Richard K, Ligon, Keith L, Mills, Gordon B, Cantley, Lewis C, Chin, Lynda
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Published in PloS one (14.11.2012)
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Estrogen Regulates Snail and Slug in the Down-Regulation of E-Cadherin and Induces Metastatic Potential of Ovarian Cancer Cells through Estrogen Receptor α
Park, Se-Hyung, Cheung, Lydia W. T, Wong, Alice S. T, Leung, Peter C. K
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2008)
Published in Molecular endocrinology (Baltimore, Md.) (01.09.2008)
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Strategic combination therapies for ovarian cancer
Li, Xinran, Angel Sn Ng, Mak, Victor Cy, Chan, Karen Kl, Cheung, Annie Ny, Cheung, Lydia Wt
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Cancer‐associated missense mutations enhance the pluripotency reprogramming activity of OCT4 and SOX17
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Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases
Li, Xinran, Lau, Amy Y. T., Ng, Angel S. N., Aldehaiman, Abdullah, Zhou, Yuan, Ng, Patrick K. S., Arold, Stefan T., Cheung, Lydia W. T.
Published in Proceedings of the National Academy of Sciences - PNAS (14.09.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (14.09.2021)
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Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium
Cheung, Lydia W T, Walkiewicz, Katarzyna W, Besong, Tabot M D, Guo, Huifang, Hawke, David H, Arold, Stefan T, Mills, Gordon B
Published in eLife (29.07.2015)
Published in eLife (29.07.2015)
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Gonadotropin-releasing hormone promotes ovarian cancer cell invasiveness through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9
CHEUNG, Lydia W. T, LEUNG, Peter C. K, WONG, Alice S. T
Published in Cancer research (Chicago, Ill.) (15.11.2006)
Published in Cancer research (Chicago, Ill.) (15.11.2006)
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A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets
Zhou, Peng, Chan, Becky K.C., Wan, Yuk Kei, Yuen, Chaya T.L., Choi, Gigi C.G., Li, Xinran, Tong, Cindy S.W., Zhong, Sophia S.W., Sun, Jieran, Bao, Yufan, Mak, Silvia Y.L., Chow, Maggie Z.Y., Khaw, Jien Vei, Leung, Suet Yi, Zheng, Zongli, Cheung, Lydia W.T., Tan, Kaeling, Wong, Koon Ho, Chan, H.Y. Edwin, Wong, Alan S.L.
Published in Cell reports (Cambridge) (11.08.2020)
Published in Cell reports (Cambridge) (11.08.2020)
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