Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase
Garcin, Elsa D, Getzoff, Elizabeth D, Arvai, Andrew S, Rosenfeld, Robin J, Kroeger, Matt D, Crane, Brian R, Andersson, Gunilla, Andrews, Glen, Hamley, Peter J, Mallinder, Philip R, Nicholls, David J, St-Gallay, Stephen A, Tinker, Alan C, Gensmantel, Nigel P, Mete, Antonio, Cheshire, David R, Connolly, Stephen, Stuehr, Dennis J, Åberg, Anders, Wallace, Alan V, Tainer, John A
Published in Nature chemical biology (01.11.2008)
Published in Nature chemical biology (01.11.2008)
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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
Cheshire, David R., Åberg, Anders, Andersson, Gunilla M.K., Andrews, Glen, Beaton, Haydn G., Birkinshaw, Timothy N., Boughton-Smith, Nigel, Connolly, Stephen, Cook, Tony R., Cooper, Anne, Cooper, Sally L., Cox, David, Dixon, John, Gensmantel, Nigel, Hamley, Peter J., Harrison, Richard, Hartopp, Paul, Käck, Helena, Leeson, Paul D., Luker, Timothy, Mete, Antonio, Millichip, Ian, Nicholls, David J., Pimm, Austen D., St-Gallay, Steve A., Wallace, Alan V.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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QSAR and the Rational Design of Long-Acting Dual D2-Receptor/β2-Adrenoceptor Agonists
Austin, Rupert P, Barton, Patrick, Bonnert, Roger V, Brown, Roger C, Cage, Peter A, Cheshire, David R, Davis, Andrew M, Dougall, Iain G, Ince, Francis, Pairaudeau, Garry, Young, Alan
Published in Journal of medicinal chemistry (17.07.2003)
Published in Journal of medicinal chemistry (17.07.2003)
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2-Aminopyridines as Highly Selective Inducible Nitric Oxide Synthase Inhibitors. Differential Binding Modes Dependent on Nitrogen Substitution
Connolly, Stephen, Aberg, Anders, Arvai, Andrew, Beaton, Haydn G, Cheshire, David R, Cook, Anthony R, Cooper, Sally, Cox, David, Hamley, Peter, Mallinder, Phil, Millichip, Ian, Nicholls, David J, Rosenfeld, Robin J, St-Gallay, Stephen A, Tainer, John, Tinker, Alan C, Wallace, Alan V
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Palladium catalysed amination of electron deficient halothiophenes
Luker, Tim J, Beaton, Haydn G, Whiting, Mat, Mete, Antonio, Cheshire, David R
Published in Tetrahedron letters (30.09.2000)
Published in Tetrahedron letters (30.09.2000)
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Dual D2-Receptor and β2-Adrenoceptor Agonists for the Treatment of Airway Diseases. 1. Discovery and Biological Evaluation of Some 7-(2-Aminoethyl)- 4-hydroxybenzothiazol-2(3H)-one Analogues
Bonnert, Roger V, Brown, Roger C, Chapman, David, Cheshire, David R, Dixon, John, Ince, Francis, Kinchin, Elizabeth C, Lyons, Amanda J, Davis, Andrew M, Hallam, Catherine, Harper, Stephen T, Unitt, John F, Dougall, Iain G, Jackson, Dale M, McKechnie, Kenneth, Young, Alan, Simpson, Wilfred T
Published in Journal of medicinal chemistry (03.12.1998)
Published in Journal of medicinal chemistry (03.12.1998)
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On Baldwin's kinetic barrier against 5-(enol-endo)-exo-trigonal closures: a comparison of ionic and analogous radical reactions, and a new synthesis of cyclopentanones
CLIVE, D. L. J, CHESHIRE, D. R
Published in Journal of the Chemical Society. Chemical communications (1987)
Published in Journal of the Chemical Society. Chemical communications (1987)
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QSAR and the rational design of long-acting dual D2-receptor/beta 2-adrenoceptor agonists
Austin, Rupert P, Barton, Patrick, Bonnert, Roger V, Brown, Roger C, Cage, Peter A, Cheshire, David R, Davis, Andrew M, Dougall, Iain G, Ince, Francis, Pairaudeau, Garry, Young, Alan
Published in Journal of medicinal chemistry (17.07.2003)
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Published in Journal of medicinal chemistry (17.07.2003)
Journal Article
QSAR and the Rational Design of Long-Acting Dual D 2 -Receptor/β 2 -Adrenoceptor Agonists
Austin, Rupert P., Barton, Patrick, Bonnert, Roger V., Brown, Roger C., Cage, Peter A., Cheshire, David R., Davis, Andrew M., Dougall, Iain G., Ince, Francis, Pairaudeau, Garry, Young, Alan
Published in Journal of medicinal chemistry (01.07.2003)
Published in Journal of medicinal chemistry (01.07.2003)
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Dual D 2 -Receptor and β 2 -Adrenoceptor Agonists for the Treatment of Airway Diseases. 1. Discovery and Biological Evaluation of Some 7-(2-Aminoethyl)- 4-hydroxybenzothiazol-2(3 H )-one Analogues
Bonnert, Roger V., Brown, Roger C., Chapman, David, Cheshire, David R., Dixon, John, Ince, Francis, Kinchin, Elizabeth C., Lyons, Amanda J., Davis, Andrew M., Hallam, Catherine, Harper, Stephen T., Unitt, John F., Dougall, Iain G., Jackson, Dale M., McKechnie, Kenneth, Young, Alan, Simpson, Wilfred T.
Published in Journal of medicinal chemistry (01.12.1998)
Published in Journal of medicinal chemistry (01.12.1998)
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Pyrrolo[3,4-d]pyrimidinone derivatives and their use as medicaments
TOMKINSSON NICHOLAS P, PERRY MATTHEW W. D, CHESHIRE DAVID R, DONALD DAVID K, HARRISON RICHARD P
Year of Publication 08.05.2001
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Year of Publication 08.05.2001
Patent
Pyrrolo[3,4-d]pyrimidinone derivatives and their use as medicaments
COOPER MARTIN E, TOMKINSSON NICHOLAS P, CHESHIRE DAVID R, DONALD DAVID K, FURBER MARK, HARRISON RICHARD P, PERRY MATTHEW W.D
Year of Publication 28.02.2002
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Year of Publication 28.02.2002
Patent