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Published in Cancer immunology research (01.04.2020)
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Marzec, Michal, Zhang, Qian, Goradia, Ami, Raghunath, Puthiyaveettil N, Liu, Xiaobin, Paessler, Michele, Wang, Hong Yi, Wysocka, Maria, Cheng, Mangeng, Ruggeri, Bruce A, Wasik, Mariusz A
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2008)
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Activation of Hepatocyte Growth Factor/MET Signaling as a Mechanism of Acquired Resistance to a Novel YAP1/TEAD Small Molecule Inhibitor
Moure, Casey J, Vara, Brandon, Cheng, Mangeng M, Sondey, Christopher, Muise, Eric, Park, Eunsil, Vela Ramirez, Julia Eulalia, Su, Dan, D'Souza, Shanti, Yan, Qingyun, Yeung, Charles S, Zhang, Minjia, Mansueto, My Sam, Linn, Doug, Buchanan, Mark, Foti, Robert, DiMauro, Erin, Long, Brian, Simov, Vladimir, Barry, Evan R
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Anaplastic lymphoma kinase is required for neurogenesis in the developing central nervous system of zebrafish
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Published in PloS one (08.05.2013)
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Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates
Kern, Jeffrey C, Cancilla, Mark, Dooney, Deborah, Kwasnjuk, Kristen, Zhang, Rena, Beaumont, Maribel, Figueroa, Isabel, Hsieh, SuChun, Liang, Linda, Tomazela, Daniela, Zhang, Jeffrey, Brandish, Philip E, Palmieri, Anthony, Stivers, Peter, Cheng, Mangeng, Feng, Guo, Geda, Prasanthi, Shah, Sanjiv, Beck, Andrew, Bresson, Damien, Firdos, Juhi, Gately, Dennis, Knudsen, Nick, Manibusan, Anthony, Schultz, Peter G, Sun, Ying, Garbaccio, Robert M
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Pu, Qinglin, Zhang, Hongjun, Guo, Liangqin, Cheng, Mangeng, Doty, Amy C, Ferguson, Heidi, Fradera, Xavier, Lesburg, Charles A, McGowan, Meredeth A, Miller, J. Richard, Geda, Prasanthi, Song, Xuelei, Otte, Karin, Sciammetta, Nunzio, Solban, Nicolas, Yu, Wensheng, Sloman, David L, Zhou, Hua, Lammens, Alfred, Neumann, Lars, Bennett, David Jonathan, Pasternak, Alexander, Han, Yongxin
Published in ACS medicinal chemistry letters (13.08.2020)
Published in ACS medicinal chemistry letters (13.08.2020)
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Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)
Ott, Gregory R, Cheng, Mangeng, Learn, Keith S, Wagner, Jason, Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew, Mesaros, Eugen F, Ghose, Arup K, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Dobrzanski, Pawel, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin, Huang, Zeqi, Aimone, Lisa D, Bruckheimer, Elizabeth, Anderson, Nathan, Friedman, Jay, Fernandez, Sandra V, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D
Published in Journal of medicinal chemistry (25.08.2016)
Published in Journal of medicinal chemistry (25.08.2016)
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Mutation-Independent Anaplastic Lymphoma Kinase Overexpression in Poor Prognosis Neuroblastoma Patients
PASSONI, Lorena, LONG, Luca, DEL GROSSO, Federica, TONINI, Gian Paolo, MANGENG CHENG, GAMBACORTI-PASSERINI, Carlo, ANICHINI, Andrea, FOSSATI-BELLANI, Franca, DI NICOLA, Massimo, LUKSCH, Roberto, COLLINI, Paola, LUCE COLUCCIA, Addolorata Maria, BOZZI, Fabio, PODDA, Marta, GREGORIO, Andrea, GAMBINI, Claudio, GARAVENTA, Alberto, PISTOIA, Vito
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Published in Cancer research (Chicago, Ill.) (15.09.2009)
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Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy
Zhang, Hongjun, Liu, Kun, Pu, Qinglin, Achab, Abdelghani, Ardolino, Michael J, Cheng, Mangeng, Deng, Yongqi, Doty, Amy C, Ferguson, Heidi, Fradera, Xavier, Knemeyer, Ian, Kurukulasuriya, Ravi, Lam, Yu-hong, Lesburg, Charles A, Martinot, Theodore A, McGowan, Meredeth A, Miller, J. Richard, Otte, Karin, Biju, Purakattle J, Sciammetta, Nunzio, Solban, Nicolas, Yu, Wensheng, Zhou, Hua, Wang, Xiao, Bennett, David Jonathan, Han, Yongxin
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
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Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase‑1 (IDO1)
White, Catherine, McGowan, Meredeth A, Zhou, Hua, Sciammetta, Nunzio, Fradera, Xavier, Lim, Jongwon, Joshi, Elizabeth M, Andrews, Christine, Nickbarg, Elliott B, Cowley, Phillip, Trewick, Sarah, Augustin, Martin, von Köenig, Konstanze, Lesburg, Charles A, Otte, Karin, Knemeyer, Ian, Woo, Hyun, Yu, Wensheng, Cheng, Mangeng, Spacciapoli, Peter, Geda, Prasanthi, Song, Xuelei, Smotrov, Nadya, Curran, Patrick, Heo, Mee Ra, Abeywickrema, Pravien, Miller, J. Richard, Bennett, David Jonathan, Han, Yongxin
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes
Piva, Roberto, Pellegrino, Elisa, Mattioli, Michela, Agnelli, Luca, Lombardi, Luigia, Boccalatte, Francesco, Costa, Giulia, Ruggeri, Bruce A, Cheng, Mangeng, Chiarle, Roberto, Palestro, Giorgio, Neri, Antonino, Inghirami, Giorgio
Published in The Journal of clinical investigation (01.12.2006)
Published in The Journal of clinical investigation (01.12.2006)
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Therapeutic efficacy of the bromodomain inhibitor OTX015/MK-8628 in ALK-positive anaplastic large cell lymphoma: an alternative modality to overcome resistant phenotypes
Boi, Michela, Todaro, Maria, Vurchio, Valentina, Yang, Shao Ning, Moon, John, Kwee, Ivo, Rinaldi, Andrea, Pan, Heng, Crescenzo, Ramona, Cheng, Mangeng, Cerchietti, Leandro, Elemento, Olivier, Riveiro, Maria E, Cvitkovic, Esteban, Bertoni, Francesco, Inghirami, Giorgio
Published in Oncotarget (29.11.2016)
Published in Oncotarget (29.11.2016)
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Discovery of an Orally Efficacious Inhibitor of Anaplastic Lymphoma Kinase
Gingrich, Diane E, Lisko, Joseph G, Curry, Matthew A, Cheng, Mangeng, Quail, Matthew, Lu, Lihui, Wan, Weihua, Albom, Mark S, Angeles, Thelma S, Aimone, Lisa D, Haltiwanger, R. Curtis, Wells-Knecht, Kevin, Ott, Gregory R, Ghose, Arup K, Ator, Mark A, Ruggeri, Bruce, Dorsey, Bruce D
Published in Journal of medicinal chemistry (24.05.2012)
Published in Journal of medicinal chemistry (24.05.2012)
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Pyrazolone-based anaplastic lymphoma kinase (ALK) inhibitors: Control of selectivity by a benzyloxy group
Tripathy, Rabindranath, McHugh, Robert J., Ghose, Arup K., Ott, Gregory R., Angeles, Thelma S., Albom, Mark S., Huang, Zeck, Aimone, Lisa D., Cheng, Mangeng, Dorsey, Bruce D.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL
Boccalatte, Francesco E., Voena, Claudia, Riganti, Chiara, Bosia, Amalia, D'Amico, Lucia, Riera, Ludovica, Cheng, Mangeng, Ruggeri, Bruce, Jensen, Ole N., Goss, Valerie L., Lee, Kimberly, Nardone, Julie, Rush, John, Polakiewicz, Roberto D., Comb, Michael J., Chiarle, Roberto, Inghirami, Giorgio
Published in Blood (19.03.2009)
Published in Blood (19.03.2009)
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Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models
Mesaros, Eugen F., Burke, Jason P., Parrish, Jonathan D., Dugan, Benjamin J., Anzalone, Andrew V., Angeles, Thelma S., Albom, Mark S., Aimone, Lisa D., Quail, Matthew R., Wan, Weihua, Lu, Lihui, Huang, Zeqi, Ator, Mark A., Ruggeri, Bruce A., Cheng, Mangeng, Ott, Gregory R., Dorsey, Bruce D.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells
Wan, Weihua, Albom, Mark S., Lu, Lihui, Quail, Matthew R., Becknell, Nadine C., Weinberg, Linda R., Reddy, Dandu R., Holskin, Beverly P., Angeles, Thelma S., Underiner, Ted L., Meyer, Sheryl L., Hudkins, Robert L., Dorsey, Bruce D., Ator, Mark A., Ruggeri, Bruce A., Cheng, Mangeng
Published in Blood (15.02.2006)
Published in Blood (15.02.2006)
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Synthesis and structure–activity relationships of 1,2,3,4-tetrahydropyrido[2,3- b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase
Milkiewicz, Karen L., Weinberg, Linda R., Albom, Mark S., Angeles, Thelma S., Cheng, Mangeng, Ghose, Arup K., Roemmele, Renee C., Theroff, Jay P., Underiner, Ted L., Zificsak, Craig A., Dorsey, Bruce D.
Published in Bioorganic & medicinal chemistry (15.06.2010)
Published in Bioorganic & medicinal chemistry (15.06.2010)
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Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors
Mesaros, Eugen F, Thieu, Tho V, Wells, Gregory J, Zificsak, Craig A, Wagner, Jason C, Breslin, Henry J, Tripathy, Rabindranath, Diebold, James L, McHugh, Robert J, Wohler, Ashley T, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Huang, Zeqi, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin J, Aimone, Lisa D, Cheng, Mangeng, Ator, Mark A, Ott, Gregory R, Dorsey, Bruce D
Published in Journal of medicinal chemistry (12.01.2012)
Published in Journal of medicinal chemistry (12.01.2012)
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