COX4I1 Controls Mitochondrial Electron Transport Chain Complex IV Assembly and Leukemia Progression in Acute Myeloid Leukemia
Zhang, Leisi, Li, Mingli, Chan, Anthony KN, Liu, Qiao, Kang, Hyunjun, Pokharel, Sheela Pangeni, Mattson, Nicole, Singh, Priyanka, Yang, Lu, Chen, Chun-Wei David
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia
Uckelmann, Hannah J, Haarer, Elena L, Takeda, Reina, Wong, Eric, Marinaccio, Christian, Hatton, Charles, Wen, Yanhe, Perner, Florian, Rajput, Masooma, Antonissen, Noa J.C., Chen, Chun-Wei David, Brunetti, Lorenzo, Armstrong, Scott A.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax
Rausch, Johanna, Dzama, Margarita M., Dolgikh, Nadezda, Stiller, Hanna, Bohl, Stephan, Lahrmann, Catharina, Kunz, Kerstin, Kessler, Linda, Echchannaoui, Hakim, Chen, Chun-Wei David, Kindler, Thomas, Burrows, Francis, Theobald, Matthias, Sasca, Daniel, Armstrong, Scott A., Kuehn, Michael
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines
Canovas Nunes, Sara, Xu, Haiming, De Vita, Serena, Anighoro, Andrew, Autelitano, Francois, Beaumont, Edward, Klingbeil, Pamela, McGuinness, Meaghan, Duvert, Beatrice, Harris, Chad E., Yang, Lu, Pokharel, Sheela Pangeni, Chen, Chun-Wei David, Ermann, Monika, Williams, David A.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening
Qin, Xi, Su, Rui, Yang, Lu, Chan, Anthony K.N., Deng, Xiaolan, Qing, Ying, Klemm, Lars, Müschen, Markus, Chen, Chun-Wei David, Chen, Jianjun
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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HDAC8 Promotes MLL-Rearranged Acute Myeloid Leukemia By Inhibiting p53 Acetylation
Wu, Dijiong, Li, Man, Zhang, Lianjun, Qi, Jing, Chen, Chun-Wei David, He, Xin, Zhu, Yinghui, Dong, Haojie, Sun, Jie, Li, Ling, Marcucci, Guido, Kuo, Ya-Huei
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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TP63 Fusions Drive Enhancer Rewiring, Lymphomagenesis, and Dependence on EZH2
Wu, Gongwei, Yoshida, Noriaki, Liu, Jihe, Zhang, Xiaoyang, Heavican-Foral, Tayla B., Liu, Huiyun, Nelson, Geoffrey M., Yang, Lu, Chen, Renee, Jones, Marcus Kenneth, Xu, Ran, Nirmal, Ajit Johnson, Jain, Salvia, Leahy, Catharine, Jones, Kristen Lynn, Stevenson, Kristen E., Wu, Wenchao, Louissaint, Abner, Debaize, Lydie, Chan, Wing C., Ho Sui, Shannan, Ng, Samuel, Feldman, Andrew L., Meyerson, Matthew, Adelman, Karen, Chen, chun-Wei David, Brown, Myles, Weinstock, David M.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL-Rearranged AML with Mutated FLT3
Dzama, Margarita M., Taubert, Martha C., Kunz, Kerstin, Rausch, Johanna, Chen, Chun-Wei David, Mupo, Annalisa, Hähnel, Patricia, Theobald, Matthias, Kindler, Thomas, Koche, Richard P., Vassiliou, George S., Armstrong, Scott A., Kühn, Michael W.M.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL-Rearranged Leukemias
Chan, Anthony K.N., Delaney, Christopher D., Yang, Lu, Chang, Wen-Han, Miyashita, Kazuya, Liu, Qiao, Pokharel, Sheela Pangeni, Armstrong, Scott A., Chen, Chun-Wei David
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism
Cai, Sheng F, Chu, S Haihua, Goldberg, Aaron D, Parvin, Salma, Koche, Richard, Glass, Jacob L, Stein, Eytan M., Tallman, Martin S., Sen, Filiz, Famulare, Christopher, Cusan, Monica, Huang, Chun-Hao, Chen, Chun-Wei David, Zou, Lihua, Cordner, Keith B, Durani, Vidushi, Kini, Mitali, Rex, Madison, Zuber, Johannes, Baslan, Timour, Lowe, Scott W., Rienhoff, Hugh Young, Levine, Ross L., Armstrong, Scott A.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis
Lee, Jaewoong, Xiao, Gang, Cosgun, Kadriye Nehir Nehir, Geng, Huimin, Ma, Ning, Chan, Lai N, Kume, Kohei, Nix, Matthew, Chen, Zhengshan, Chen, Chun-Wei David, Chen, Jianjun, Khairnar, Vishal, Wiita, Arun P., Thomas-Tikhonenko, Andrei, Farzan, Michael, Diamond, Michael S., Jung, Jae U, Vaidehi, Nagarajan, Müschen, Markus
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling
Lee, Jaewoong, Kume, Kohei, Chen, Zhengshan, Xiao, Gang, Cosgun, Kadriye Nehir Nehir, Chen, Liting, Chan, Lai N, Klemm, Lars, Chen, Chun-Wei David, Ma, Ning, Chan, Wing C., Forman, Stephen J, Zammarchi, Francesca, Van Berkel, Patrick, Melnick, Ari, Ngo, Vu N, Geng, Huimin, Luger, Selina M., Litzow, Mark, McManus, Michael T, Vaidehi, Nagarajan, Paietta, Elisabeth M., Meffre, Eric, Weinstock, David M., Müschen, Markus
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Non-Catalytic Role of SETD1A Regulates DNA Repair in Leukemia
Hoshii, Takayuki, Cifani, Paolo, Nakadai, Tomoyoshi, Feng, Zhaohui, Huang, Chun-Hao, Koche, Richard, Delaney, Christopher D, Chen, Chun-Wei David, Lowe, Scott W., Roeder, Robert, Kentsis, Alex, Armstrong, Scott A.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL-Rearranged Leukemia to DOT1L Inhibition
Chen, Chun-Wei David, Delaney, Christopher, Xu, Haiming, Koche, Richard, Lujambio Goizueta, Amaya, Hoshii, Takayuki, Cusan, Monica, Chabon, Jonathan, Valerio, Daria Gianina, Kuehn, Michael, Wang, Xi, Cai, Sheng, Chu, S. Haihua, Chen, Yining Kevin, He, Justin, Huang, Chun-Hao, Feng, Zhaohui, Krivtsov, Andrei, Qi, Jun, Bradner, James E., Lowe, Scott W., Armstrong, Scott A.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Genome-Wide RNAi Screen Identifies The Mechanistic Role For DOT1L In MLL-Rearranged Leukemia
David Chen, Chun-Wei, Sinha, Amit U., Qi, Jun, Deshpande, Aniruddha J, Zhu, Nan, Koche, Richard, Eng, Rowena, Chang, Jenny, Hahn, William C., Bradner, James E, Armstrong, Scott A.
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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