Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor
Garcia Fortanet, Jorge, Chen, Christine Hiu-Tung, Chen, Ying-Nan P, Chen, Zhouliang, Deng, Zhan, Firestone, Brant, Fekkes, Peter, Fodor, Michelle, Fortin, Pascal D, Fridrich, Cary, Grunenfelder, Denise, Ho, Samuel, Kang, Zhao B, Karki, Rajesh, Kato, Mitsunori, Keen, Nick, LaBonte, Laura R, Larrow, Jay, Lenoir, Francois, Liu, Gang, Liu, Shumei, Lombardo, Franco, Majumdar, Dyuti, Meyer, Matthew J, Palermo, Mark, Perez, Lawrence, Pu, Minying, Ramsey, Timothy, Sellers, William R, Shultz, Michael D, Stams, Travis, Towler, Christopher, Wang, Ping, Williams, Sarah L, Zhang, Ji-Hu, LaMarche, Matthew J
Published in Journal of medicinal chemistry (08.09.2016)
Published in Journal of medicinal chemistry (08.09.2016)
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Journal Article
Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor
Shultz, Michael D, Cheung, Atwood K, Kirby, Christina A, Firestone, Brant, Fan, Jianmei, Chen, Christine Hiu-Tung, Chen, Zhouliang, Chin, Donovan N, DiPietro, Lucian, Fazal, Aleem, Feng, Yun, Fortin, Pascal D, Gould, Ty, Lagu, Bharat, Lei, Huangshu, Lenoir, Francois, Majumdar, Dyuti, Ochala, Etienne, Palermo, M. G, Pham, Ly, Pu, Minying, Smith, Troy, Stams, Travis, Tomlinson, Ronald C, Touré, B. Barry, Visser, Michael, Wang, Run Ming, Waters, Nigel J, Shao, Wenlin
Published in Journal of medicinal chemistry (22.08.2013)
Published in Journal of medicinal chemistry (22.08.2013)
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Journal Article
Fluorous Synthesis of Hydantoin-, Piperazinedione-, and Benzodiazepinedione-Fused Tricyclic and Tetracyclic Ring Systems
Zhang, Wei, Lu, Yimin, Chen, Christine Hiu-Tung, Curran, Dennis P., Geib, Steven
Published in European Journal of Organic Chemistry (01.05.2006)
Published in European Journal of Organic Chemistry (01.05.2006)
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Book Review
Journal Article
“Addition” and “Subtraction”: Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors
Chen, Xin, Giraldes, John, Sprague, Elizabeth R, Shakya, Subarna, Chen, Zhuoliang, Wang, Yaping, Joud, Carol, Mathieu, Simon, Chen, Christine Hiu-Tung, Straub, Christopher, Duca, Jose, Hurov, Kristen, Yuan, Yanqiu, Shao, Wenlin, Touré, B. Barry
Published in Journal of medicinal chemistry (09.03.2017)
Published in Journal of medicinal chemistry (09.03.2017)
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Journal Article
SHP2 N- N- N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2
WILLIAMS SARAH, CHEN CHRISTINE HIU TUNG, TOURE BAKARY BARRY, LAMARCHE MATTHEW J, DORE MICHAEL, GIRALDES JOHN WILLIAM, CHEN ZHUOLIANG, SMITH TROY DOUGLAS, KATO MITSUNORI, SENDZIK MARTIN, FORTANET JORGE GARCIA, PEREZ LAWRENCE BLAS, KARKI RAJESH
Year of Publication 28.02.2023
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Year of Publication 28.02.2023
Patent
Fluorous electrophilic scavengers for solution-phase parallel synthesis
Zhang, Wei, Chen, Christine Hiu-Tung, Nagashima, Tadamichi
Published in Tetrahedron letters (03.03.2003)
Published in Tetrahedron letters (03.03.2003)
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Journal Article
Transfer of Chirality in Radical Cyclizations. Cyclization of o-Haloacrylanilides to Oxindoles with Transfer of Axial Chirality to a Newly Formed Stereocenter
Curran, Dennis P, Liu, Weidong, Chen, Christine Hiu-Tung
Published in Journal of the American Chemical Society (01.12.1999)
Published in Journal of the American Chemical Society (01.12.1999)
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Journal Article
Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors
Cho, Young Shin, Angove, Hayley, Brain, Christopher, Chen, Christine Hiu-Tung, Cheng, Hong, Cheng, Robert, Chopra, Rajiv, Chung, Kristy, Congreve, Miles, Dagostin, Claudio, Davis, Deborah J, Feltell, Ruth, Giraldes, John, Hiscock, Steven D, Kim, Sunkyu, Kovats, Steven, Lagu, Bharat, Lewry, Kim, Loo, Alice, Lu, Yipin, Luzzio, Michael, Maniara, Wiesia, McMenamin, Rachel, Mortenson, Paul N, Benning, Rajdeep, O'Reilly, Marc, Rees, David C, Shen, Junqing, Smith, Troy, Wang, Yaping, Williams, Glyn, Woolford, Alison J.-A, Wrona, Wojciech, Xu, Mei, Yang, Fan, Howard, Steven
Published in ACS medicinal chemistry letters (14.06.2012)
Published in ACS medicinal chemistry letters (14.06.2012)
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Journal Article
HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES
CHEN CHRISTINE HIU TUNG, LIU GANG, BROOKS CLINTON A, CHO, YOUNG SHIN, JIANG LEI, SHULTZ MICHAEL
Year of Publication 28.01.2014
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Year of Publication 28.01.2014
Patent
N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2
WILLIAMS SARAH, CHEN CHRISTINE HIU TUNG, TOURE BAKARY BARRY, LAMARCHE MATTHEW J, DORE MICHAEL, GIRALDES JOHN WILLIAM, CHEN ZHUOLIANG, SMITH TROY DOUGLAS, KATO MITSUNORI, SENDZIK MARTIN, FORTANET JORGE GARCIA, PEREZ LAWRENCE BLAS, KARKI RAJESH
Year of Publication 31.08.2016
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Year of Publication 31.08.2016
Patent
4-PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS
CHEN CHRISTINE HIU TUNG, TOURE BAKARY BARRY, PALERMO MARK G, DIPIETRO LUCIAN V, FAN JIANME, SHULTZ MICHAEL DAVID, CHIN NOEL CHIN
Year of Publication 02.05.2014
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Year of Publication 02.05.2014
Patent