H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
Harutyunyan, Ashot S., Krug, Brian, Chen, Haifen, Papillon-Cavanagh, Simon, Zeinieh, Michele, De Jay, Nicolas, Deshmukh, Shriya, Chen, Carol C. L., Belle, Jad, Mikael, Leonie G., Marchione, Dylan M., Li, Rui, Nikbakht, Hamid, Hu, Bo, Cagnone, Gael, Cheung, Warren A., Mohammadnia, Abdulshakour, Bechet, Denise, Faury, Damien, McConechy, Melissa K, Pathania, Manav, Jain, Siddhant U., Ellezam, Benjamin, Weil, Alexander G., Montpetit, Alexandre, Salomoni, Paolo, Pastinen, Tomi, Lu, Chao, Lewis, Peter W., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Majewski, Jacek
Published in Nature communications (19.03.2019)
Published in Nature communications (19.03.2019)
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Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
Boileau, Meaghan, Shirinian, Margret, Gayden, Tenzin, Harutyunyan, Ashot S., Chen, Carol C. L., Mikael, Leonie G., Duncan, Heather M., Neumann, Andrea L., Arreba-Tutusaus, Patricia, De Jay, Nicolas, Zeinieh, Michele, Rossokhata, Katya, Zhang, Yelu, Nikbakht, Hamid, Mouawad, Carine, Massoud, Radwan, Frey, Felice, Nasr, Rihab, El Cheikh, Jean, El Sabban, Marwan, Kleinman, Claudia L., Mahfouz, Rami, Minden, Mark D., Jabado, Nada, Bazarbachi, Ali, Eppert, Kolja
Published in Nature communications (28.06.2019)
Published in Nature communications (28.06.2019)
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Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Khazaei, Sima, Chen, Carol C.L., Andrade, Augusto Faria, Kabir, Nisha, Azarafshar, Pariya, Morcos, Shahir M., França, Josiane Alves, Lopes, Mariana, Lund, Peder J., Danieau, Geoffroy, Worme, Samantha, Adnani, Lata, Nzirorera, Nadine, Chen, Xiao, Yogarajah, Gayathri, Russo, Caterina, Zeinieh, Michele, Wong, Cassandra J., Bryant, Laura, Hébert, Steven, Tong, Bethany, Sihota, Tianna S., Faury, Damien, Puligandla, Evan, Jawhar, Wajih, Sandy, Veronica, Cowan, Mitra, Nakada, Emily M., Jerome-Majewska, Loydie A., Ellezam, Benjamin, Gomes, Carolina Cavalieri, Denecke, Jonas, Lessel, Davor, McDonald, Marie T., Pizoli, Carolyn E., Taylor, Kathryn, Cocanougher, Benjamin T., Bhoj, Elizabeth J., Gingras, Anne-Claude, Garcia, Benjamin A., Lu, Chao, Campos, Eric I., Kleinman, Claudia L., Garzia, Livia, Jabado, Nada
Published in Cell (16.03.2023)
Published in Cell (16.03.2023)
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TULIPs decorate the three-dimensional genome of PFA ependymoma
Johnston, Michael J., Lee, John J.Y., Hu, Bo, Nikolic, Ana, Hasheminasabgorji, Elham, Baguette, Audrey, Paik, Seungil, Chen, Haifen, Kumar, Sachin, Chen, Carol C.L., Jessa, Selin, Balin, Polina, Fong, Vernon, Zwaig, Melissa, Michealraj, Kulandaimanuvel Antony, Chen, Xun, Zhang, Yanlin, Varadharajan, Srinidhi, Billon, Pierre, Juretic, Nikoleta, Daniels, Craig, Rao, Amulya Nageswara, Giannini, Caterina, Thompson, Eric M., Garami, Miklos, Hauser, Peter, Pocza, Timea, Ra, Young Shin, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa, Perek-Polnik, Marta, Agnihotri, Sameer, Mack, Stephen, Ellezam, Benjamin, Weil, Alex, Rich, Jeremy, Bourque, Guillaume, Chan, Jennifer A., Yong, V. Wee, Lupien, Mathieu, Ragoussis, Jiannis, Kleinman, Claudia, Majewski, Jacek, Blanchette, Mathieu, Jabado, Nada, Taylor, Michael D., Gallo, Marco
Published in Cell (05.09.2024)
Published in Cell (05.09.2024)
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Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas
Krug, Brian, De Jay, Nicolas, Harutyunyan, Ashot S., Deshmukh, Shriya, Marchione, Dylan M., Guilhamon, Paul, Bertrand, Kelsey C., Mikael, Leonie G., McConechy, Melissa K., Chen, Carol C.L., Khazaei, Sima, Koncar, Robert F., Agnihotri, Sameer, Faury, Damien, Ellezam, Benjamin, Weil, Alexander G., Ursini-Siegel, Josie, De Carvalho, Daniel D., Dirks, Peter B., Lewis, Peter W., Salomoni, Paolo, Lupien, Mathieu, Arrowsmith, Cheryl, Lasko, Paul F., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Mack, Stephen C.
Published in Cancer cell (13.05.2019)
Published in Cancer cell (13.05.2019)
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Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks
Chaouch, Amel, Berlandi, Johannes, Chen, Carol C.L., Frey, Felice, Badini, Shireen, Harutyunyan, Ashot S., Chen, Xiao, Krug, Brian, Hébert, Steven, Jeibmann, Astrid, Lu, Chao, Kleinman, Claudia L., Hasselblatt, Martin, Lasko, Paul, Shirinian, Margret, Jabado, Nada
Published in Molecular cell (02.12.2021)
Published in Molecular cell (02.12.2021)
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Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas
Krug, Brian, De Jay, Nicolas, Harutyunyan, Ashot S., Deshmukh, Shriya, Marchione, Dylan M., Guilhamon, Paul, Bertrand, Kelsey C., Mikael, Leonie G., McConechy, Melissa K., Chen, Carol C.L., Khazaei, Sima, Koncar, Robert F., Agnihotri, Sameer, Faury, Damien, Ellezam, Benjamin, Weil, Alexander G., Ursini-Siegel, Josie, De Carvalho, Daniel D., Dirks, Peter B., Lewis, Peter W., Salomoni, Paolo, Lupien, Mathieu, Arrowsmith, Cheryl, Lasko, Paul F., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Mack, Stephen C.
Published in Cancer cell (16.09.2019)
Published in Cancer cell (16.09.2019)
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Meet the authors: Amel Chaouch, Carol C.L. Chen, and Margret Shirinian
Published in Molecular cell
(02.12.2021)
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Journal Article
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis
Chen, Carol C.L., Deshmukh, Shriya, Jessa, Selin, Hadjadj, Djihad, Lisi, Véronique, Andrade, Augusto Faria, Faury, Damien, Jawhar, Wajih, Dali, Rola, Suzuki, Hiromichi, Pathania, Manav, A, Deli, Dubois, Frank, Woodward, Eleanor, Hébert, Steven, Coutelier, Marie, Karamchandani, Jason, Albrecht, Steffen, Brandner, Sebastian, De Jay, Nicolas, Gayden, Tenzin, Bajic, Andrea, Harutyunyan, Ashot S., Marchione, Dylan M., Mikael, Leonie G., Juretic, Nikoleta, Zeinieh, Michele, Russo, Caterina, Maestro, Nicola, Bassenden, Angelia V., Hauser, Peter, Virga, József, Bognar, Laszlo, Klekner, Almos, Zapotocky, Michal, Vicha, Ales, Krskova, Lenka, Vanova, Katerina, Zamecnik, Josef, Sumerauer, David, Ekert, Paul G., Ziegler, David S., Ellezam, Benjamin, Filbin, Mariella G., Blanchette, Mathieu, Hansford, Jordan R., Khuong-Quang, Dong-Anh, Berghuis, Albert M., Weil, Alexander G., Garcia, Benjamin A., Garzia, Livia, Mack, Stephen C., Beroukhim, Rameen, Ligon, Keith L., Taylor, Michael D., Bandopadhayay, Pratiti, Kramm, Christoph, Pfister, Stefan M., Korshunov, Andrey, Sturm, Dominik, Jones, David T.W., Salomoni, Paolo, Kleinman, Claudia L., Jabado, Nada
Published in Cell (10.12.2020)
Published in Cell (10.12.2020)
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H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone
Khazaei, Sima, De Jay, Nicolas, Deshmukh, Shriya, Hendrikse, Liam D, Jawhar, Wajih, Chen, Carol C L, Mikael, Leonie G, Faury, Damien, Marchione, Dylan M, Lanoix, Joel, Bonneil, Éric, Ishii, Takeaki, Jain, Siddhant U, Rossokhata, Kateryna, Sihota, Tianna S, Eveleigh, Robert, Lisi, Véronique, Harutyunyan, Ashot S, Jung, Sungmi, Karamchandani, Jason, Dickson, Brendan C, Turcotte, Robert, Wunder, Jay S, Thibault, Pierre, Lewis, Peter W, Garcia, Benjamin A, Mack, Stephen C, Taylor, Michael D, Garzia, Livia, Kleinman, Claudia L, Jabado, Nada
Published in Cancer discovery (01.12.2020)
Published in Cancer discovery (01.12.2020)
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